ID A0A0C2FJ31_9ACTN Unreviewed; 668 AA.
AC A0A0C2FJ31;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Ricin-type beta-trefoil lectin domain protein {ECO:0000313|EMBL:KIH99279.1};
GN ORFNames=LP52_09005 {ECO:0000313|EMBL:KIH99279.1};
OS Streptomonospora alba.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Streptomonospora.
OX NCBI_TaxID=183763 {ECO:0000313|EMBL:KIH99279.1, ECO:0000313|Proteomes:UP000031675};
RN [1] {ECO:0000313|Proteomes:UP000031675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 90003 {ECO:0000313|Proteomes:UP000031675};
RX PubMed=25601074; DOI=10.1016/j.chembiol.2014.11.017;
RA Metelev M., Tietz J.I., Melby J.O., Blair P.M., Zhu L., Livnat I.,
RA Severinov K., Mitchell D.A.;
RT "Structure, bioactivity, and resistance mechanism of streptomonomicin, an
RT unusual lasso Peptide from an understudied halophilic actinomycete.";
RL Chem. Biol. 22:241-250(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIH99279.1}.
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DR EMBL; JROO01000014; KIH99279.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C2FJ31; -.
DR STRING; 183763.LP52_09005; -.
DR Proteomes; UP000031675; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR039514; 6GAL-like.
DR InterPro; IPR039743; 6GAL/EXGAL.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR42767; ENDO-BETA-1,6-GALACTANASE; 1.
DR PANTHER; PTHR42767:SF1; GLYCO_HYDR_30_2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14587; Glyco_hydr_30_2; 1.
DR Pfam; PF14200; RicinB_lectin_2; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 4: Predicted;
KW Lectin {ECO:0000313|EMBL:KIH99279.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031675};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..668
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002148968"
FT DOMAIN 31..263
FT /note="Endo-beta-1,6-galactanase-like"
FT /evidence="ECO:0000259|Pfam:PF14587"
FT DOMAIN 612..667
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|Pfam:PF14200"
SQ SEQUENCE 668 AA; 71100 MW; 58BEB9FF2D2B2169 CRC64;
MAAAATVCLL AASAAGPAQA EPASTATVTP DPSYQGQEFE GWGTSLAWFA NATGDYPEPI
RRELARLVFG DDGLDLNIAR YNIGGGNAPD VPDYLRAGGA VEGWWKAPEG TARQDTDWWS
AQDSDDWDPR ADATQRWWVE TVKDDVDHWE AFSNSPPWFM TESGYVSGGF EATEDQLAAG
SVDDFAAYLV GATERLERAH GIEVDTLEPF NEPNTDYWST TLGPDGDPVG GRQEGAHMGP
ELQQDVIRAL EGRLSGAETG AVVAAMDETN PETFARNWLS YPEDVREKVA QLNVHTYGTG
GRTAVRDLAK AAKRPLWMSE TGGDWGEGQR WGGGGQDFET MSTGLGLAGH MVDDLRELEP
SAWVFWQPVE DYDNMAPGGE SDSGGNWGSI QIPFSCTAED TLQTCPVRTN TKFDTARNFT
HYIRPGDRLI GVDDASSAAA AAQSGDAATV VHVNDTAGPR EVTVDLSKFA RVAPDATVTP
VVTDSGGALV EHEAVPVQEG AASVTVPAES VTTLVVDGVF GVAADAALVQ PGRDYRLSGV
QSGKALTAEG GSVVIDATEP GDAAQLWDIA EVTRGHDNRQ RYVLTNRDRR LAVRGDSLVL
EPARGRAGAV AQWIMSTTGD GSWTLVNRAT GALIDVAGQA TRDGAPVSVW RPTSGDNQRW
RITAADGG
//
