ID A0A0C2IXK6_THEKT Unreviewed; 679 AA.
AC A0A0C2IXK6;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Integrin alpha-8 {ECO:0000313|EMBL:KII61592.1};
GN ORFNames=RF11_07514 {ECO:0000313|EMBL:KII61592.1};
OS Thelohanellus kitauei (Myxosporean).
OC Eukaryota; Metazoa; Cnidaria; Myxozoa; Myxosporea; Bivalvulida;
OC Platysporina; Myxobolidae; Thelohanellus.
OX NCBI_TaxID=669202 {ECO:0000313|EMBL:KII61592.1, ECO:0000313|Proteomes:UP000031668};
RN [1] {ECO:0000313|EMBL:KII61592.1, ECO:0000313|Proteomes:UP000031668}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Wuqing {ECO:0000313|EMBL:KII61592.1};
RX PubMed=25381665; DOI=10.1093/gbe/evu247;
RA Yang Y., Xiong J., Zhou Z., Huo F., Miao W., Ran C., Liu Y., Zhang J.,
RA Feng J., Wang M., Wang M., Wang L., Yao B.;
RT "The genome of the myxosporean Thelohanellus kitauei shows adaptations to
RT nutrient acquisition within its fish host.";
RL Genome Biol. Evol. 6:3182-3198(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KII61592.1}.
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DR EMBL; JWZT01005319; KII61592.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C2IXK6; -.
DR EnsemblMetazoa; KII61592; KII61592; RF11_07514.
DR Proteomes; UP000031668; Unassembled WGS sequence.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF122; INTEGRIN ALPHA-PS1; 1.
DR Pfam; PF01839; FG-GAP; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000031668};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|RuleBase:RU003762}.
FT TRANSMEM 629..651
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 47..108
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 679 AA; 76548 MW; BFEE52180C5D70DC CRC64;
MDQFVNISAF QRVGTKCKSW TDCAVLIHRE SRLFLCTRNN SYFSKFQPIQ GLYGENKSSC
LFGYSMTLLN DMNHDGIDEL VVSAPFCSVS QGGGAIYIYL SSKDFGYRNG HFDKLMSVNG
VPQTFFGIKV VGFRAKRADD RYGHDSSAGL IVSSPDGNEI YVLRTNPVIS VAHKVAFEKN
INKHHICSKE SPGSNLSCSQ VLICLSLFYQ PGTGESFDGA EDTKYDFQLH LYGDERAVLL
GNPLISAEPQ KTICKYIQIG FYQPFKNYLN PIDLNLTYSI LEDDTERDIP YFAFLNEPRV
DISFYYEKRC IDVNACRPDL MLAPIDPFDK FVNYSFRSAQ QMQDGTNFSF GIQSHGEPGY
DPELVITVPT DIKIIKILFN GIQAVDVNHT ENQGVEMLSV SIPNELNHNV SIRVTVTFSI
KQLHKPSLWA HLLVKCAYGT QMTNNVLNIS IVPRFESSFE VGSWMEPNET SLVVNPMNLT
ISQRIPINLH ITINNHGPSF ARNVPLSIFF PYKAKGQQIL GLAGLELSES GNCQYDVSEV
TNSHKAENES SAHLNLIYGQ IECLIYTIND QPVNLSVEFM TMKNASNLLE NITGIPLNFL
VIFNEMNFSY FKTITKSNDS NVTQVSPEVP WWLIILVSGI FLLLIACIPL FKYAKRRFNR
KLRQSTIKSY KQVLASANF
//
