ID A0A0C2JJJ7_9ACTN Unreviewed; 348 AA.
AC A0A0C2JJJ7;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=LacI family transcriptional regulator {ECO:0000313|EMBL:KIH97077.1};
GN ORFNames=LP52_21070 {ECO:0000313|EMBL:KIH97077.1};
OS Streptomonospora alba.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Nocardiopsaceae; Streptomonospora.
OX NCBI_TaxID=183763 {ECO:0000313|EMBL:KIH97077.1, ECO:0000313|Proteomes:UP000031675};
RN [1] {ECO:0000313|Proteomes:UP000031675}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YIM 90003 {ECO:0000313|Proteomes:UP000031675};
RX PubMed=25601074; DOI=10.1016/j.chembiol.2014.11.017;
RA Metelev M., Tietz J.I., Melby J.O., Blair P.M., Zhu L., Livnat I.,
RA Severinov K., Mitchell D.A.;
RT "Structure, bioactivity, and resistance mechanism of streptomonomicin, an
RT unusual lasso Peptide from an understudied halophilic actinomycete.";
RL Chem. Biol. 22:241-250(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIH97077.1}.
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DR EMBL; JROO01000043; KIH97077.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C2JJJ7; -.
DR STRING; 183763.LP52_21070; -.
DR Proteomes; UP000031675; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd01392; HTH_LacI; 1.
DR CDD; cd06293; PBP1_LacI-like; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 1.10.260.40; lambda repressor-like DNA-binding domains; 1.
DR InterPro; IPR000843; HTH_LacI.
DR InterPro; IPR046335; LacI/GalR-like_sensor.
DR InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR30146:SF121; HTH-TYPE TRANSCRIPTIONAL REPRESSOR CYTR; 1.
DR PANTHER; PTHR30146; LACI-RELATED TRANSCRIPTIONAL REPRESSOR; 1.
DR Pfam; PF00356; LacI; 1.
DR Pfam; PF13377; Peripla_BP_3; 1.
DR SMART; SM00354; HTH_LACI; 1.
DR SUPFAM; SSF47413; lambda repressor-like DNA-binding domains; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00356; HTH_LACI_1; 1.
DR PROSITE; PS50932; HTH_LACI_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000031675};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 11..65
FT /note="HTH lacI-type"
FT /evidence="ECO:0000259|PROSITE:PS50932"
SQ SEQUENCE 348 AA; 36880 MW; F73A6F1768F56B6C CRC64;
MSSTEGTNRP VGINDVAARA GVSPGTVSNV LNRPERVAES TRRRVERAVQ ELDYVRNSSG
RNLRSGRSDS VGLLVLDVTN PFFAEVARGV EDTAGEEGLA VVLLNSAEQA ARQRRSMRLL
AEQRAAGAVI MPVDNDTEDL LWLRKQGVPG VLLDIGDVPG ETACSVSVDN HAGGLAAGRH
LINLGHERIT YLGGPADLEQ CRTRLEGLCA AVAEAGSDPD EAVRVIRTAQ LNAESGEKAV
EEVLAGGPKR RPQAVFCTND QLAVGVLKGL GGRGLSAPGD LSVVGYDDVD LAALVHPGLT
TVGQPKYELG RAAMQLLLSE LGDPDHRHER LRFAPELVVR GSTAAYRP
//
