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Database: UniProt
Entry: A0A0C2UWD1_9BACL
LinkDB: A0A0C2UWD1_9BACL
Original site: A0A0C2UWD1_9BACL 
ID   A0A0C2UWD1_9BACL        Unreviewed;       450 AA.
AC   A0A0C2UWD1;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   05-JUL-2017, entry version 22.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=SD71_08345 {ECO:0000313|EMBL:KIL36278.1};
OS   Cohnella kolymensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae; Cohnella.
OX   NCBI_TaxID=1590652 {ECO:0000313|EMBL:KIL36278.1, ECO:0000313|Proteomes:UP000054526};
RN   [1] {ECO:0000313|EMBL:KIL36278.1, ECO:0000313|Proteomes:UP000054526}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VKM B-2846 {ECO:0000313|EMBL:KIL36278.1,
RC   ECO:0000313|Proteomes:UP000054526};
RA   Karlyshev A.V., Kudryashova E.B.;
RT   "Draft genome sequence of Cohnella kolymensis strain B-2846.";
RL   Submitted (DEC-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KIL36278.1}.
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DR   EMBL; JXAL01000012; KIL36278.1; -; Genomic_DNA.
DR   RefSeq; WP_041061994.1; NZ_JXAL01000012.1.
DR   EnsemblBacteria; KIL36278; KIL36278; SD71_08345.
DR   Proteomes; UP000054526; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054526};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054526}.
FT   DOMAIN      144    272       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      356    425       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     152    159       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   450 AA;  51312 MW;  1CA02EE51F86EEBE CRC64;
     MDNRNSDIWQ QVLSVIQTKL SKPSFDTWFK STKASFLSDN VVVVTAPTTF AAEWLETRYT
     KLVTSTLSEY VGRPVDVRFA IEEVRSAEPP APFPQKPAVR EPASEDTIMH MLNPKYTFDT
     FVIGAGNRFA HAASLAVAEA PAKAYNPFFL YGGVGLGKTH LMHAIGHYIL EHNPHMKVLY
     LSSEKFTNEF INAIRDNRGE SFRNKYRNID VLLIDDIQFL AGKEGTQEEF FHTFNALHEE
     HKQIVISSDR PPKEIPTLEE RLRSRFEWGL ITDIQPPDLE TRIAILRKKA RAENLDIPNE
     AMMYIANMID SNIRELEGAL IRIVAYSSLT NQDISSHLAA EALKDILPSG RNRVLTMQDI
     QQRVGEYYGL KLEDFKARKR TKAIAFPRQI AMYLSRELTD YSLPKIGDAF GGRDHTTVIH
     AHDKITQQLK IDQELYKIIN SLTEKIKNLS
//
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