ID   A0A0C3MTT4_9PROT        Unreviewed;      1129 AA.
AC   A0A0C3MTT4;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Guanylate cyclase {ECO:0000313|EMBL:KIO50123.1};
GN   ORFNames=SQ11_03810 {ECO:0000313|EMBL:KIO50123.1};
OS   Nitrosospira sp. NpAV.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC   Nitrosomonadaceae; Nitrosospira.
OX   NCBI_TaxID=58133 {ECO:0000313|EMBL:KIO50123.1, ECO:0000313|Proteomes:UP000031969};
RN   [1] {ECO:0000313|EMBL:KIO50123.1, ECO:0000313|Proteomes:UP000031969}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NpAV {ECO:0000313|EMBL:KIO50123.1,
RC   ECO:0000313|Proteomes:UP000031969};
RA   Rice M.C., Lim C.K., Sayavedra-Soto L.A., Norton J.M., Klotz M.G.;
RT   "Nitrosospira sp. NpAV genome sequencing.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KIO50123.1}.
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DR   EMBL; JXQM01000003; KIO50123.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C3MTT4; -.
DR   Proteomes; UP000031969; Unassembled WGS sequence.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0042802; F:identical protein binding; IEA:InterPro.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd09487; SAM_superfamily; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR011717; TPR-4.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   Pfam; PF07721; TPR_4; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT   DOMAIN          1..62
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          95..227
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1129 AA;  125494 MW;  B23280CC37E223BD CRC64;
     MNDRVSEWLD NLGLGIYRES FQHNAITWDV LPELNDGDLE ALGVLLGHRK KILRAIAQLS
     QGAEVMGPRP IPVGVIPEEQ PFPPERDQAE RRQLTVMFCD LVDSTALSSR LDPEDLQDVI
     RRFLDACSQA IDRFNGYIAK YMGDGMLVYF GYPHAHENDA ERAVHAGLAI LDAVRGFNRD
     NPHLQFGIAA RTGIATGQVV VGELMGQDTA KERSVFGETP NLAARLQALA EPNQLIIDSA
     TKRLVGNEFE LLDLGALSLK GFGTPIQAWQ VLSIRLSASR FESYRSSHLA KFVGREQEIS
     LLLGRWREAL EGEGQVVLLS GEAGIGKSRI ARSVCDRLED ERYQTIQFQC SPYHTNTVLY
     PAINFLRQAA GLASHDSAQA QLNKLDAMAI ESGIDSQETV SLLADLLSIQ GDHRYPLLNV
     SSEKRKDMTL EALVHHLQRL AARCPLLFTV EDAHWLDPTT QELMTRIIGR IRQMRVLLLI
     TSRPDFKPVW SEYSYVTSLM LSRLSRRHSA ELVATMTGGK ALPPEVQQAI LAKADGIPLY
     IETLTENVLG SGLLVEGNDA FILKGPLRGL PIPDSLQALL MERVDRLGSA KEIVQTGAAI
     GREFTYELLR ATVEVPDSEL RNALDLFVAS GLVLQEGEIP LATYYFKHAL VQEAAYSTLP
     RKPRRVLHAR IAKALESQFS ERVNMEPELL AYHFEQAGLT GPAVDYWHRA ARRDAERSAN
     IEALNHFNRA LDLLKELPQS PERNALELEL LLARGAPLLS VKGYASDEME QNCRRAKDLL
     QEHSGSVDQF IAIRGLWVFH LVRGHLANAR GLAEDLLVLA HREQSPDLLI EAHLALGVTC
     LFLGRFDEAR THLSATKSLD DPNRQRSQGF FFQDPGISAR SFLARTFWIL GEIEHVEPLA
     LEAIGLARAL EHPFTMVFAL TSLSWIYAGA RNAKRTLELT DEAIAVSTQY SFELGLAWAT
     ASQGWALTES GQKEGLAKLI DGLSATRATG ANTNNTFMLA LLAEVYLRRD RIDEGLTTIE
     EAQKLAVAVE ELFWQAELFR LKGELLLKQS DESVQEAEAC LRTALKIAQD QHATMFELRA
     ATSLAKLWGK LNKADDAKRI LNAVCSRFNE RVDNLDLIEA KTVLEQLGA
//