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Database: UniProt
Entry: A0A0C4DGF4_HUMAN
LinkDB: A0A0C4DGF4_HUMAN
Original site: A0A0C4DGF4_HUMAN 
ID   A0A0C4DGF4_HUMAN        Unreviewed;      1159 AA.
AC   A0A0C4DGF4;
DT   01-APR-2015, integrated into UniProtKB/TrEMBL.
DT   01-APR-2015, sequence version 1.
DT   27-SEP-2017, entry version 17.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 5 {ECO:0000313|Ensembl:ENSP00000434383};
DE   Flags: Fragment;
GN   Name=TRPM5 {ECO:0000313|Ensembl:ENSP00000434383};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000434383, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000434383}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H.,
RA   Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M.,
RA   Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E.,
RA   Kremitzki C., Oddy L., Du H., Sun H., Bradshaw-Cordum H., Ali J.,
RA   Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C.,
RA   Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J.,
RA   Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A.,
RA   Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K.,
RA   Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M.,
RA   Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N.,
RA   Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M.,
RA   Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E.,
RA   Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P.,
RA   Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A.,
RA   Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A.,
RA   Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T.,
RA   Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D.,
RA   Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X.,
RA   McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D.,
RA   Waterston R.H., Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2
RT   and 4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
RN   [3] {ECO:0000313|Ensembl:ENSP00000434383}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2015) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSP00000434383}.
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DR   EMBL; AC124057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   UniGene; Hs.272287; -.
DR   ProteinModelPortal; A0A0C4DGF4; -.
DR   PaxDb; A0A0C4DGF4; -.
DR   Ensembl; ENST00000533881; ENSP00000434383; ENSG00000070985.
DR   EuPathDB; HostDB:ENSG00000070985.13; -.
DR   HGNC; HGNC:14323; TRPM5.
DR   OpenTargets; ENSG00000070985; -.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   Bgee; ENSG00000070985; -.
DR   ExpressionAtlas; A0A0C4DGF4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro.
DR   GO; GO:0050909; P:sensory perception of taste; IEA:InterPro.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR029577; TRPM5.
DR   PANTHER; PTHR13800:SF18; PTHR13800:SF18; 1.
DR   Pfam; PF00520; Ion_trans; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000005640};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    722    748       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    806    825       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    868    889       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    944    964       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      736    980       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSP00000434383}.
SQ   SEQUENCE   1159 AA;  130776 MW;  E3165E8C1125363B CRC64;
     PGSPGDAEDR RELGLHRGEV NFGGSGKKRG KFVRVPSGVA PSVLFDLLLA EWHLPAPNLV
     VSLVGEEQPF AMKSWLRDVL RKGLVKAAQS TGAWILTSAL RVGLARHVGQ AVRDHSLAST
     STKVRVVAVG MASLGRVLHR RILEEAQVHE DFPVHYPEDD GGSQGPLCSL DSNLSHFILV
     EPGPPGKGDG LTELRLRLEK HISEQRAGYG GTGSIEIPVL CLLVNGDPNT LERISRAVEQ
     AAPWLILVGS GGIADVLAAL VNQPHLLVPK VAEKQFKEKF PSKHFSWEDI VRWTKLLQNI
     TSHQHLLTVY DFEQEGSEEL DTVILKALVK ACKSHSQEPQ DYLDELKLAV AWDRVDIAKS
     EIFNGDVEWK SCDLEEVMVD ALVSNKPEFV RLFVDNGADV ADFLTYGRLQ ELYRSVSRKS
     LLFDLLQRKQ EEARLTLAGL GTQQAREPPA GPPAFSLHEV SRVLKDFLQD ACRGFYQDGR
     PGDRRRAEKG PAKRPTGQKW LLDLNQKSEN PWRDLFLWAV LQNRHEMATY FWAMGQEGVA
     AALAACKILK EMSHLETEAE AARATREAKY ERLALDLFSE CYSNSEARAF ALLVRRNRCW
     SKTTCLHLAT EADAKAFFAH DGVQAFLTRI WWGDMAAGTP ILRLLGAFLC PALVYTNLIT
     FSEEAPLRTG LEDLQDLDSL DTEKSPLYGL QSRVEELVEA PRAQGDRGPR AVFLLTRWRK
     FWGAPVTVFL GNVVMYFAFL FLFTYVLLVD FRPPPQGPSG PEVTLYFWVF TLVLEEIRQG
     FFTDEDTHLV KKFTLYVGDN WNKCDMVAIF LFIVGVTCRM LPSAFEAGRT VLAMDFMVFT
     LRLIHIFAIH KQLGPKIIVV ERMMKDVFFF LFFLSVWLVA YGVTTQALLH PHDGRLEWIF
     RRVLYRPYLQ IFGQIPLDEI DEARVNCSTH PLLLEDSPSC PSLYANWLVI LLLVTFLLVT
     NVLLMNLLIA MFSYTFQVVQ GNADMFWKFQ RYNLIVEYHE RPALAPPFIL LSHLSLTLRR
     VFKKEAEHKR EHLERDLPDP LDQKVVTWET VQKENFLSKM EKRRRDSEGE VLRKTAHRVD
     FIAKYLGGLR EQEKRIKCLE SQINYCSVLV SSVADVLAQG GGPRSSQHCG EGSQLVAADH
     RGGLDGWEQP GAGQPPSDT
//
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