ID A0A0C4E4D1_MAGP6 Unreviewed; 1163 AA.
AC A0A0C4E4D1;
DT 01-APR-2015, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=MAPG_07324 {ECO:0000313|EMBL:KLU88337.1};
OS Magnaporthiopsis poae (strain ATCC 64411 / 73-15) (Kentucky bluegrass
OS fungus) (Magnaporthe poae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Magnaporthales; Magnaporthaceae; Magnaporthiopsis.
OX NCBI_TaxID=644358 {ECO:0000313|EnsemblFungi:MAPG_07324T0, ECO:0000313|Proteomes:UP000011715};
RN [1] {ECO:0000313|EMBL:KLU88337.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 64411 {ECO:0000313|EMBL:KLU88337.1};
RG The Broad Institute Genome Sequencing Platform;
RG Broad Institute Genome Sequencing Center for Infectious Disease;
RA Ma L.-J., Dead R., Young S., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The Genome Sequence of Magnaporthe poae strain ATCC 64411.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000011715}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 64411 / 73-15 {ECO:0000313|Proteomes:UP000011715};
RA Ma L.-J., Dead R., Young S., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E.R., Heiman D., Hepburn T., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Pearson M., Roberts A., Saif S., Shea T.,
RA Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA Haas B., Nusbaum C., Birren B.;
RT "The genome sequence of Magnaporthe poae strain ATCC 64411.";
RL Submitted (MAY-2010) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:KLU88337.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 64411 {ECO:0000313|EMBL:KLU88337.1};
RA Ma L.-J., Dead R., Young S.K., Zeng Q., Gargeya S., Fitzgerald M., Haas B.,
RA Abouelleil A., Alvarado L., Arachchi H.M., Berlin A., Brown A.,
RA Chapman S.B., Chen Z., Dunbar C., Freedman E., Gearin G., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Howarth C., Larson L., Lui A.,
RA MacDonald P.J.P., Mehta T., Montmayeur A., Murphy C., Neiman D.,
RA Pearson M., Priest M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P.,
RA Stolte C., Sykes S., Yandava C., Wortman J., Nusbaum C., Birren B.;
RT "Annotation of Magnaporthe poae ATCC 64411.";
RL Submitted (MAR-2011) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EnsemblFungi:MAPG_07324T0}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 64411 / 73-15 {ECO:0000313|EnsemblFungi:MAPG_07324T0};
RX PubMed=26416668; DOI=10.1534/g3.115.020057;
RA Okagaki L.H., Nunes C.C., Sailsbery J., Clay B., Brown D., John T., Oh Y.,
RA Young N., Fitzgerald M., Haas B.J., Zeng Q., Young S., Adiconis X., Fan L.,
RA Levin J.Z., Mitchell T.K., Okubara P.A., Farman M.L., Kohn L.M., Birren B.,
RA Ma L.-J., Dean R.A.;
RT "Genome sequences of three phytopathogenic species of the Magnaporthaceae
RT family of fungi.";
RL G3 (Bethesda) 5:2539-2545(2015).
RN [5] {ECO:0000313|EnsemblFungi:MAPG_07324T0}
RP IDENTIFICATION.
RC STRAIN=ATCC 64411 {ECO:0000313|EnsemblFungi:MAPG_07324T0};
RG EnsemblFungi;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; ADBL01001770; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; GL876971; KLU88337.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C4E4D1; -.
DR STRING; 644358.A0A0C4E4D1; -.
DR EnsemblFungi; MAPG_07324T0; MAPG_07324T0; MAPG_07324.
DR VEuPathDB; FungiDB:MAPG_07324; -.
DR eggNOG; KOG0942; Eukaryota.
DR OMA; HWLMTNR; -.
DR OrthoDB; 1386at2759; -.
DR Proteomes; UP000011715; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR PANTHER; PTHR45700:SF2; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS50096; IQ; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011715};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 794..1163
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 1131
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 1163 AA; 131142 MW; B4236BD23A3E65DD CRC64;
MFPTFSGTSR RPRNVNLSGQ RSDPFAGTSW GAGPSTGTTK SVAEAQADRQ RRQQERDRLR
AAQNIQRTWR GHRQRQTVQA ERRGLFADLY HRQPPLSPDE RVSRAFPLLP SLVSADREED
YETLTMFIED LAQDESGVLS PQHTSTLRLK SLVHTLVATA TKTEKPAARL AVLLKLLVLL
VERRPESAAD SLDTYYTLLA HIIKEERLDI HDRSGLPLTA ISLPLRAPTD ILASKARRAF
VVYFLASPDL ILSEEQKNVL VEAIEPERLS TAVVDEFSSG ALASASKEEL LWLLARFIDI
QRAQSATPHT PAYVKALHVQ LSNLAGEIRS RFTPVSSRDA PGLEAAAAKP QLPHYVSKQL
SFLVERGEIS NLLGKFVFNY GATSSETAGD ASILAGYILT LIRCFPSRGD DIRMRLYLAD
IAGQTEKLPS LRFFWEAVKT TTVFSRVIRD EKAAHAFLLQ RTYFQSSSTD SAWDREWRMV
LLFLELYVFV LRLTDDEDFF SGISGALTGG TPPSRLAACS LPLEDLEKLS LFLKNLGFTL
YYHAADLLQV DGAADNATQS LDDVVRLTSK TKGKARDKVT SSFTVISGID FEAFRNIVIT
AIRMLYERDS RRPFLPTDHW LMTSRFDMES FLAAVVLEEQ RQHDMRGDES EEDMSDEDDD
LEGMFGSSSH QVFSWAGQRR SRHALVELKT RRRKQQRDRT LAMIGPKLEI LRNMPFLIPF
RTRVQIFRQF VHLDKERRRN GYVDADQWRQ FVLGAGGRDP TPGRGVIGRH HAKIKRGNVF
DDAFEQFYPL GDGLKEPIQI TFVDQFDTVE AGIDGGGVTK EFLTSITMEA FGGSQHNLFV
ANKSNAMYPN PSSLDQLQES LKRLGFLEGS EEWTLQMRTL LEQYEFLGRI VGKCMYEGIL
IDIAFAGFFL LKWVSAATDL GYRASINDVR EMDEELYQGL LRLKNMQSDV SELDLDFTIN
DQVSPLGEET MTITRNLVPN GKDVAVTNEN RPLYISYIAR HRLVAQPLQQ TRAFLRGLGS
IIDPAWLSMF NQSELQRLVG GDSSEIDLED LRRHTVYSGV YVVGDDGKNH PTVDLFWQAM
HEFQDSERRA VLKYVTSTPR APLLGFSQLK PMFSIRDGGA DPKRLPSAST CVNLLKLPRY
PTLEILKNKL RYAISSNAGF DLS
//
