ID   A0A0C4YKE2_9BURK        Unreviewed;       619 AA.
AC   A0A0C4YKE2;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Choline-sulfatase {ECO:0000313|EMBL:AJG23538.1};
DE            EC=3.1.6.6 {ECO:0000313|EMBL:AJG23538.1};
GN   ORFNames=RR42_s1950 {ECO:0000313|EMBL:AJG23538.1};
OS   Cupriavidus basilensis.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=68895 {ECO:0000313|EMBL:AJG23538.1, ECO:0000313|Proteomes:UP000031843};
RN   [1] {ECO:0000313|EMBL:AJG23538.1, ECO:0000313|Proteomes:UP000031843}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=4G11 {ECO:0000313|EMBL:AJG23538.1};
RX   PubMed=25977418;
RA   Ray J., Waters R.J., Skerker J.M., Kuehl J.V., Price M.N., Huang J.,
RA   Chakraborty R., Arkin A.P., Deutschbauer A.;
RT   "Complete Genome Sequence of Cupriavidus basilensis 4G11, Isolated from the
RT   Oak Ridge Field Research Center Site.";
RL   Genome Announc. 3:0-0(2015).
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP010537; AJG23538.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C4YKE2; -.
DR   STRING; 68895.RR42_s1950; -.
DR   KEGG; cbw:RR42_s1950; -.
DR   Proteomes; UP000031843; Chromosome secondary.
DR   GO; GO:0047753; F:choline-sulfatase activity; IEA:UniProtKB-EC.
DR   CDD; cd16027; SGSH; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR43751:SF3; N-ACETYLGALACTOSAMINE 6-SULFATASE (GALNS); 1.
DR   PANTHER; PTHR43751; SULFATASE; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:AJG23538.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031843};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           39..619
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002181792"
FT   DOMAIN          53..338
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
SQ   SEQUENCE   619 AA;  69274 MW;  146048D7BE2FA6C2 CRC64;
     MNVHNRTRNP FACLPRAMRL AMHGFMLLVA AQSGLLHAQQ QPQPQPQQQR NQPNILWITV
     EDITTFIGAY GDREVKTPNI DQLAREGVLY THAYQTAGVC APARAALITG MYPTSVGAQH
     MRTGPGEIQM PGRSASQRPD GLPATYSVVL PEQVKAFPEY LRKAGYYTTN NQKQDYQFEA
     PVTVWDENGP AASFRNRPKG KPFFSVFNFF LTHEVMVALR KDPLLNDPVS VPVPPIFPDT
     AAVRGDIARM YTNIELMDRQ VGELIQMLKD DGLYDNTIIF FFADNGGNLP WMKRELLERG
     THVPFIVRHP GGQHGGTRRD ELVSGVDMAP TVLSLAGVPV PGYMQGQAFL GEQRASIPRR
     YVFAARDRMD TEYDRVRMVR DQRYRYLYNY MPELPYYQDL KFRMKLPMMR DILKLRAEGS
     LPPATAAWFK TKPVEELYDA EQDPWEQHNL ADDPKYKNKL EELRHAFQAW TAKVGDKGGV
     PEREMLKQMW QGGSEPPATA IPEVRRAGNG VDGVDGVQIA CATPGASIGY WIERPAARAT
     AATHVVQSWD YERLAGELFG MGLAKVGDMR PVPPSWSVYG GETIALRPGE ILHVNAMRIG
     FRPAAIDYAD GAVVSPAAK
//