ID A0A0C5BFF4_9MICO Unreviewed; 435 AA.
AC A0A0C5BFF4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE SubName: Full=Pyrimidine-nucleoside phosphorylase {ECO:0000313|EMBL:KKM47314.1};
DE SubName: Full=Thymidine phosphorylase {ECO:0000313|EMBL:PPI13802.1};
GN ORFNames=C5C51_08780 {ECO:0000313|EMBL:PPI13802.1}, VT73_00205
GN {ECO:0000313|EMBL:KKM47314.1};
OS Rathayibacter toxicus.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Microbacteriaceae;
OC Rathayibacter.
OX NCBI_TaxID=145458 {ECO:0000313|EMBL:KKM47314.1, ECO:0000313|Proteomes:UP000052979};
RN [1] {ECO:0000313|EMBL:KKM47314.1, ECO:0000313|Proteomes:UP000052979}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FH142 {ECO:0000313|EMBL:KKM47314.1,
RC ECO:0000313|Proteomes:UP000052979};
RG Consortium for Microbial Forensics and Genomics (microFORGE);
RA Knight B.M., Roberts D.P., Lin D., Hari K., Fletcher J., Melcher U.,
RA Blagden T., Luster D.G., Sechler A.J., Schneider W.L., Winegar R.A.;
RT "Draft genome sequence of Rathayibacter toxicus strain FH-142 (AKA 70134 or
RT CS 32), a Western Australian isolate.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:PPI13802.1, ECO:0000313|Proteomes:UP000237966}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FH99 {ECO:0000313|EMBL:PPI13802.1,
RC ECO:0000313|Proteomes:UP000237966};
RA Davis E.W.II., Tabima J.F., Weisberg A.J., Lopes L.D., Wiseman M.S.,
RA Wiseman M.S., Pupko T., Belcher M.S., Sechler A.J., Tancos M.A.,
RA Schroeder B.K., Murray T.D., Luster D.G., Schneider W.L., Rogers E.,
RA Andreote F.D., Grunwald N.J., Putnam M.L., Chang J.H.;
RT "Bacteriophage NCPPB3778 and a type I-E CRISPR drive the evolution of the
RT US Biological Select Agent, Rathayibacter toxicus.";
RL Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC phosphorylase family. {ECO:0000256|ARBA:ARBA00006915}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KKM47314.1}.
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DR EMBL; LBFI01000001; KKM47314.1; -; Genomic_DNA.
DR EMBL; PSWU01000013; PPI13802.1; -; Genomic_DNA.
DR RefSeq; WP_027691762.1; NZ_PSXM01000010.1.
DR AlphaFoldDB; A0A0C5BFF4; -.
DR STRING; 145458.APU90_08095; -.
DR GeneID; 66873633; -.
DR KEGG; rtc:APU90_08095; -.
DR KEGG; rtx:TI83_08980; -.
DR PATRIC; fig|145458.7.peg.2047; -.
DR eggNOG; COG0213; Bacteria.
DR OrthoDB; 9763887at2; -.
DR Proteomes; UP000052979; Unassembled WGS sequence.
DR Proteomes; UP000237966; Unassembled WGS sequence.
DR GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro.
DR GO; GO:0016154; F:pyrimidine-nucleoside phosphorylase activity; IEA:InterPro.
DR GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR Gene3D; 3.40.1030.10; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR Gene3D; 3.90.1170.30; Pyrimidine nucleoside phosphorylase-like, C-terminal domain; 1.
DR InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom_sf.
DR InterPro; IPR035902; Nuc_phospho_transferase.
DR InterPro; IPR036566; PYNP-like_C_sf.
DR InterPro; IPR013102; PYNP_C.
DR InterPro; IPR018090; Pyrmidine_PPas_bac/euk.
DR InterPro; IPR017872; Pyrmidine_PPase_CS.
DR InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR NCBIfam; TIGR02644; Y_phosphoryl; 1.
DR PANTHER; PTHR10515; THYMIDINE PHOSPHORYLASE; 1.
DR PANTHER; PTHR10515:SF0; THYMIDINE PHOSPHORYLASE; 1.
DR Pfam; PF02885; Glycos_trans_3N; 1.
DR Pfam; PF00591; Glycos_transf_3; 1.
DR Pfam; PF07831; PYNP_C; 1.
DR PIRSF; PIRSF000478; TP_PyNP; 1.
DR SMART; SM00941; PYNP_C; 1.
DR SUPFAM; SSF52418; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR SUPFAM; SSF47648; Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain; 1.
DR SUPFAM; SSF54680; Pyrimidine nucleoside phosphorylase C-terminal domain; 1.
DR PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Reference proteome {ECO:0000313|Proteomes:UP000052979};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 343..417
FT /note="Pyrimidine nucleoside phosphorylase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00941"
SQ SEQUENCE 435 AA; 45713 MW; 588A2CECABCA93CC CRC64;
MTTVSPVESF DAVDIIRAKR DRCTLSTAQI AWLIDAYTRG YVAGEQMAAF AMAVLLNGMD
RDEVRDLTLA MIASGERMRF DGLGKSTVDK HSTGGVGDKI TLPLMPLVAS FGVAVPQLSG
RGLGYTGGTL DKLESIPGWR ADLSHREILE QLRTVGGVIC AAGPGLAPAD KKLYALRDIT
GTVEAIPLIA SSIMSKKIAE GTQALVLDVK FGSGAFLGDR DRSRELAQAM VDLGNDAGVR
TTALLTNMNV PLGFAIGNAN EVRESVDVLA GGGPADVREL TLTLAREMLA LVGVSDADLE
GALDDGSAMD CWRAAIRAQG GDPAAALPVA RETHVIVAER DGVLVEQQAL PFGIAAWRLG
AGRARQCDAV QHAAGIDLHA KPGDRVRAGQ PLFTLSADEP ARFERAQEAL QGAYRIGDEG
EEVHDGGPLV AGRIG
//
