ID A0A0C5G3F3_9ACTN Unreviewed; 313 AA.
AC A0A0C5G3F3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=RNA methyltransferase {ECO:0000313|EMBL:AJP03105.1};
GN ORFNames=TU94_18125 {ECO:0000313|EMBL:AJP03105.1};
OS Streptomyces cyaneogriseus subsp. noncyanogenus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=477245 {ECO:0000313|EMBL:AJP03105.1, ECO:0000313|Proteomes:UP000032234};
RN [1] {ECO:0000313|EMBL:AJP03105.1, ECO:0000313|Proteomes:UP000032234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NMWT 1 {ECO:0000313|EMBL:AJP03105.1,
RC ECO:0000313|Proteomes:UP000032234};
RA Wang H., Li C., Xiang W., Wang X.;
RT "Genome sequence of thermotolerant Streptomyces cyaneogriseus subsp.
RT Noncyanogenus NMWT1, the producer of nematocidal antibiotics nemadectin.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase TrmH family.
CC {ECO:0000256|ARBA:ARBA00007228}.
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DR EMBL; CP010849; AJP03105.1; -; Genomic_DNA.
DR RefSeq; WP_044383008.1; NZ_CP010849.1.
DR AlphaFoldDB; A0A0C5G3F3; -.
DR STRING; 477245.TU94_18125; -.
DR KEGG; scw:TU94_18125; -.
DR PATRIC; fig|477245.3.peg.3833; -.
DR HOGENOM; CLU_021322_0_0_11; -.
DR OrthoDB; 9785673at2; -.
DR Proteomes; UP000032234; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR CDD; cd18103; SpoU-like_RlmB; 1.
DR Gene3D; 3.30.1330.30; -; 1.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR013123; SpoU_subst-bd.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR NCBIfam; TIGR00186; rRNA_methyl_3; 1.
DR PANTHER; PTHR46429; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR PANTHER; PTHR46429:SF1; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR Pfam; PF08032; SpoU_sub_bind; 1.
DR SMART; SM00967; SpoU_sub_bind; 1.
DR SUPFAM; SSF75217; alpha/beta knot; 1.
DR SUPFAM; SSF55315; L30e-like; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:AJP03105.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000032234};
KW Transferase {ECO:0000313|EMBL:AJP03105.1}.
FT DOMAIN 71..148
FT /note="RNA 2-O ribose methyltransferase substrate binding"
FT /evidence="ECO:0000259|SMART:SM00967"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..59
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 313 AA; 32807 MW; 16CCF210F599A6EF CRC64;
MAANNRRMSG KKGAQVGSGG KRRRGLEGKG PTPPAEMRKG HVKQRVAQAK ARRAQGRTQG
RRGGGRSASE LVVGRNPVVE ALRGGVPAST LYVQQFIDND ERVREALQLA AERGNINLME
APRPELDRMT NGLNHQGLVL QVPPYEYAHP EDLLDAAADE GEDPLIVALD GVTDPRNLGA
VVRSVSAFGG HGVVVPERRA AGMTAGAWKT SAGTAARTPV ARATNLTRAL EQYKKAGVVV
VGLAADGEVE VGELDALAGP VVIVVGSEGK GLSRLVGETC DFRVRIPMPG GAESLNAGVA
AGVVLYEAAR RRS
//
