ID A0A0C5G4E4_9ACTN Unreviewed; 305 AA.
AC A0A0C5G4E4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Dehydrogenase {ECO:0000313|EMBL:AJP03074.1};
GN ORFNames=TU94_17920 {ECO:0000313|EMBL:AJP03074.1};
OS Streptomyces cyaneogriseus subsp. noncyanogenus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=477245 {ECO:0000313|EMBL:AJP03074.1, ECO:0000313|Proteomes:UP000032234};
RN [1] {ECO:0000313|EMBL:AJP03074.1, ECO:0000313|Proteomes:UP000032234}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NMWT 1 {ECO:0000313|EMBL:AJP03074.1,
RC ECO:0000313|Proteomes:UP000032234};
RA Wang H., Li C., Xiang W., Wang X.;
RT "Genome sequence of thermotolerant Streptomyces cyaneogriseus subsp.
RT Noncyanogenus NMWT1, the producer of nematocidal antibiotics nemadectin.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
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DR EMBL; CP010849; AJP03074.1; -; Genomic_DNA.
DR RefSeq; WP_044382979.1; NZ_CP010849.1.
DR AlphaFoldDB; A0A0C5G4E4; -.
DR SMR; A0A0C5G4E4; -.
DR STRING; 477245.TU94_17920; -.
DR KEGG; scw:TU94_17920; -.
DR PATRIC; fig|477245.3.peg.3788; -.
DR HOGENOM; CLU_035117_2_1_11; -.
DR OrthoDB; 4029976at2; -.
DR Proteomes; UP000032234; Chromosome.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048666; RedAm-like_C.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR Pfam; PF21761; RedAm-like_C; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000032234}.
FT DOMAIN 20..175
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 178..303
FT /note="NADPH-dependent reductive aminase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21761"
SQ SEQUENCE 305 AA; 31411 MW; 42D20B147B590222 CRC64;
MSVHSDQSPT GLATPTGPTV TVLGLGPMGR ALAGAFLDAG VRTTVWNRTP GRDADLTARG
ALPAASPEEA VAASDLTVVC VVNYDASDAV LRQDAVTTAL KGRTAVNLSA DTPERARDTA
AWADRHGIRY LDGAIMTPAP TIGTADAVFL FSGPQDLYGE HQPVLAALGG SHTHLGEDPG
RAAAYDIALL DIFWTAMGGY AHAVAVARAE GVTARELAPF AEGIAAILPP LFTEFAGDID
DGTYSGELNP ITSAASTMAH IVHASEAHGI DAGLMRVIEG QARRVIAQGH GGDGFSRVVE
LLGRS
//
