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Database: UniProt
Entry: A0A0C5KWA4_9SPHN
LinkDB: A0A0C5KWA4_9SPHN
Original site: A0A0C5KWA4_9SPHN 
ID   A0A0C5KWA4_9SPHN        Unreviewed;       455 AA.
AC   A0A0C5KWA4;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   05-JUL-2017, entry version 18.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=TS85_13545 {ECO:0000313|EMBL:AJP72575.1};
OS   Sphingomonas hengshuiensis.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Sphingomonas.
OX   NCBI_TaxID=1609977 {ECO:0000313|EMBL:AJP72575.1, ECO:0000313|Proteomes:UP000032300};
RN   [1] {ECO:0000313|EMBL:AJP72575.1, ECO:0000313|Proteomes:UP000032300}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WHSC-8 {ECO:0000313|EMBL:AJP72575.1,
RC   ECO:0000313|Proteomes:UP000032300};
RA   Wei S., Guo J., Su C., Wu R., Zhang Z., Liang K., Li H., Wang T.,
RA   Liu H., Zhang C., Li Z., Wang Q., Meng J.;
RT   "The complete genome of Sphingomonas hengshuiensis sp. WHSC-8 isolated
RT   from soil of Hengshui Lake.";
RL   Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP010836; AJP72575.1; -; Genomic_DNA.
DR   EnsemblBacteria; AJP72575; AJP72575; TS85_13545.
DR   KEGG; sphi:TS85_13545; -.
DR   PATRIC; fig|1609977.7.peg.2800; -.
DR   KO; K02313; -.
DR   Proteomes; UP000032300; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000032300};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032300}.
FT   DOMAIN      151    298       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      363    432       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     159    166       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   455 AA;  50583 MW;  EAC3EE6304667FDA CRC64;
     MQSVERIGME AVSKAWAHVR GNLRRSAGQR LFDQWLKPVT LVEGSTATAV RLGLPSAFMT
     QWVRNHYAER LLLEFRGVLP DVEAVTLETL ADEPLRVLTA EPEAAPAPRA APLVERPTFD
     PRFTFEHFVV DSTNRVAFNA ARAVAEPGTP RFSPLYLHSG TGQGKTHLMH ALGHAFLDAN
     PGATAIYVTG ERFMFEFVQA LRAKDTHAFK TRLRSVDLLM IDDLQFIGGK DATQEEFFHT
     VNEFMSSGKR LVIAADRAPQ ALEGFESRLA GRLGSGLVAD IKPAELELRR AIVVRKLAAM
     PAVDMPDEVI DLLAARITSN VRELEGALNR LVAYANLSNE TITIDFATVT LGEVLRSVQR
     RITIDEIQRA VSAHFEVKQL DLISERRAVA IARPRQIAMY LAKRLTTRSL PEIGRKFGGR
     DHSTVIHAVR RIEDLRTKDV EIDGAVRSLM RTLEG
//
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