ID A0A0C5VNB2_9GAMM Unreviewed; 4388 AA.
AC A0A0C5VNB2;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=PKS {ECO:0000313|EMBL:DAC80061.1};
DE SubName: Full=Polyketide synthase modules-related protein {ECO:0000313|EMBL:AJQ95776.1};
DE EC=2.3.1.39 {ECO:0000313|EMBL:AJQ95776.1};
GN Name=tarD {ECO:0000313|EMBL:DAC80061.1};
GN ORFNames=YC6258_03740 {ECO:0000313|EMBL:AJQ95776.1};
OS Gynuella sunshinyii YC6258.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Saccharospirillaceae; Gynuella.
OX NCBI_TaxID=1445510 {ECO:0000313|EMBL:AJQ95776.1, ECO:0000313|Proteomes:UP000032266};
RN [1] {ECO:0000313|EMBL:AJQ95776.1, ECO:0000313|Proteomes:UP000032266}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=YC6258 {ECO:0000313|EMBL:AJQ95776.1,
RC ECO:0000313|Proteomes:UP000032266};
RA Khan H., Chung E.J., Chung Y.R.;
RT "Full genme sequencing of cellulolytic bacterium Gynuella sunshinyii
RT YC6258T gen. nov., sp. nov.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:DAC80061.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=YC6258 {ECO:0000313|EMBL:DAC80061.1};
RX PubMed=31308532; DOI=.1038/s41589-019-0313-7;
RA Helfrich E.J.N., Ueoka R., Dolev A., Rust M., Meoded R.A., Bhushan A.,
RA Califano G., Costa R., Gugger M., Steinbeck C., Moreno P., Piel J.;
RT "Automated structure prediction of trans-acyltransferase polyketide
RT synthase products.";
RL Nat. Chem. Biol. 15:813-821(2019).
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467}.
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DR EMBL; CP007142; AJQ95776.1; -; Genomic_DNA.
DR EMBL; BK010667; DAC80061.1; -; Genomic_DNA.
DR STRING; 1445510.YC6258_03740; -.
DR KEGG; gsn:YC6258_03740; -.
DR PATRIC; fig|1445510.3.peg.3717; -.
DR HOGENOM; CLU_223614_0_0_6; -.
DR UniPathway; UPA00094; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000032266; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0004314; F:[acyl-carrier-protein] S-malonyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:UniProt.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd08953; KR_2_SDR_x; 1.
DR CDD; cd00833; PKS; 3.
DR CDD; cd05233; SDR_c; 1.
DR Gene3D; 1.10.1240.100; -; 2.
DR Gene3D; 3.40.47.10; -; 3.
DR Gene3D; 1.10.1200.10; ACP-like; 3.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 3.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR010037; FkbH_domain.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR010033; HAD_SF_ppase_IIIC.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR002347; SDR_fam.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR01686; FkbH; 1.
DR NCBIfam; TIGR01681; HAD-SF-IIIC; 1.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00106; adh_short; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 2.
DR Pfam; PF00109; ketoacyl-synt; 3.
DR Pfam; PF02801; Ketoacyl-synt_C; 3.
DR Pfam; PF08659; KR; 2.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF00550; PP-binding; 3.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00822; PKS_KR; 2.
DR SMART; SM00825; PKS_KS; 3.
DR SMART; SM00823; PKS_PP; 2.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 3.
DR SUPFAM; SSF56784; HAD-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 3.
DR PROSITE; PS50075; CARRIER; 3.
DR PROSITE; PS00606; KS3_1; 3.
DR PROSITE; PS52004; KS3_2; 3.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:AJQ95776.1};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000032266};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AJQ95776.1}.
FT DOMAIN 1144..1218
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1257..1679
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 2573..2650
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 2724..3141
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 3797..3874
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 3913..4331
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 2685..2705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4388 AA; 480241 MW; 879C591082D0E196 CRC64;
MMKLSDTEIL LSQNMVDAFA RFSRDVNPLH LDESYARKTP FSTPICYGGL AAMAMLAKVE
GIEHLKLTSL KAEFLSAVRI GCNYTLRCQA LSDDKSRIQL FDADSLLLEC QLNYVGHIQH
HIRESASDNE YGTDVEDVPV LVNAEQINTG DEFNIDYQPR WTVLSELCEQ LKMPMTVALT
NVAAVMAFSS YWIGMRLPGQ QALFSGFNAT FTESFLKCPI ECLTGSSRVV SLEREFDLIN
QEIMLSHDGV RFVNAELRAL FRPVSSLPDF SRLTAAAEFG SALAGKNILI TGASRGLGAC
LTSACLLAGA TVYGVYHKSV AGMQQLAAVL PESVRHRLVP VQGDCSHPQT YSDLTGELAA
NQQNIDYVFF SATPALHSMD LNRGNQTAFS EYLDRSFQML LTPLTELASF FSEQAKLIFI
STVAVEHPVA AWPHYVAAKS GMESLIASLV LKPNARQWYV VRLPQMRTDL VYAMGNQQRL
LAPEQAALSV LTALQTIEPE AGCYALIDRF EQSAVAHIGN LPPTSTLPES GVMTIASSFT
LDPIAEAMDI WLTNTRLNDA CQRSLQLHLA PYGQVVQTCL APDSPFYRQT SIANVLLLRL
EDAVHYRDDD ESDNNDISSA LTQAVDQYVG QCCEAISQYH GHAPLFVWLC RDSASWEQMP
GYASFRQRFS ERLTQTCHGL ASVYFRIMDH NSPPPDDELR NEMAHIPYLD HHYADISRAI
IRQLCAVRFS PKKVIVCDCD NTLWSGVVGE DGVDGIILDA GHLALQARLV SMVEQGFLVC
LCSKNNSEDV EAVFAGRKDM VLQRRHITGE RVNWQPKSDN IRSLATELNL GLDSFVFLDD
NPVEILEVEQ NLEGVLCVRI PASDQIIDLL DRFWFADRLT VTEEDRRRTE MYQGQVQRQQ
IKSTKSSLLE YIQALDIELD IQPLTLAAVP RVSQLSNKTN QFNLTTLRLD ESAVRDYCDD
ANKACWTVQV RDKFGDYGLV GALFAHRADS TLYLDNLLLS CRVLGRGVEY SLLKYLGESD
VLPASNVMIR YRPSAKNVPA LEFLQRLFPQ AGFTAQQDGD FELTRDALRM VQMQDVTADD
ESSAPVSKNP LVSTTSVLAE NRFYQWLLTA TPGQLSSVSS HTLETSDSPM KPAAVTSTVP
TPAADIWPRL KTVIEDTVVN LDGPVNENTP FDRLSLSSLM MVNLTVALSR EFACKFSSTY
LFGLKTLTDL LTKIRRDLAD QHADTGVTIA ATVTPEPLIP QPTSRPVVAS KNTVAPDDRV
AIIGIAGRYP GAANVDQLWQ LLLEGRCCIG DIPEQRWDHR ELYVPEQTGS GQSYSNSAGM
IDDVDKFDTT LFNISPKDAR LMDPQQRWFL TIAYECLLSA GYNRETIARD TGVFAGAMAK
DYQSLCAGLV AEGKVPFPYA DLYQIANRVS YFMDLSGPSI TIDTACSSSG VALHMACEAI
RKGECSQALA GGVNLILHPQ RHIQYSQMQM LSKDGLCRSF SDQASGMVMG EGVGCVLLKP
LAQALLDGDQ VYATLLSSHV NSGGRTSGFT VPNPLAQAEL IRSALNKTAI DKDSISYIEA
HGTGTPLGDP IEVEGIASAL NREQSTAAPC FVGSIKSNIG HLEPAAAIAG LTKVVLQFQH
KMLVPSLHAE TLNHRIEFDQ YRIDVPRTLT PWTSDKHPRR AGVSSFGAGG VNAHIVLEEY
ETDQQLSRLE ATGPSEQLII PLSAQSEAAL TTMIRELHEH LLRYENDLSL PAIAYTLQTG
RDEFRYRAAF MAASVTQLVS QLSAWVDMKN HDNQCVCADI KDYQNVADIF SDCDILVQQW
LSQGNIRKIA DIWVKGASLN WHRGWRIHEQ PHGAPVRIRL PGYPFMGTRQ WVEGARWQSS
RPPQHPEVAN DAIPLSVSDY FVADHVVDHQ CILPGVSYLA ALESRLRHEV QPGRSFALKQ
MLWMRPLSFS VQAQQTLHIS ALENGYVLTD SAATVYARCR LDDSVSATPA SINPENLMHT
FASALDHDQC YQRLIQQGFH YGPGLQCVEW IRYNDHQVLG YLTRRSATGT EPWALCSALL
DAGLQTTIIF NQAAQTLLPF ACDRVVFCET RWPDSVYSLA TIQQAGNERM TCDIGFYDEQ
GRALLMLQGL TLLAGKSAQS QGADFYGPVW QAVACQTDAD PVTSDTDVLI LTDEGKLPVE
LPASLSGATV QVLSSSDINR LTERQLQHSQ RLVIDLISAG QSFENHLPLL DIYRQFPVNT
RYLVVWEDRN EVTQNALGES YAGLSRALMH ETDQFQLQTL RLQHLADFPK VLTELLSAPG
AISFRYSDNQ LECLRWQALA PVPSPVPSGT AVGFESGGVY WLTGSGGVAR ALAGQLQQRY
QATVILSGRR EAALVQAEPL PENVLYMQGD INVWSDCQAI RQQILDRFGK LDGIIHTAGT
VHDERLMQQR ADDFTAVLQA KINGARHLSQ FTRQPSDPWL ILCSSIAAVV GNIGQTSYAM
ANAWLDAMAR HSVNKRIMSI NWPLWRDTGM AAGAAHLVDH NQRLGFGYLQ ADDGLNILEQ
AIQHAGIDGQ VVYLPGDEQK IQQAMNASLA PFWKAVSGQP VASAQTEVLD QADVAQQLLQ
RLFDHTNELL ELPEGVLEAD EDLSSYGFDS ISLSDFADRL NAEFDLGISP VLFFDHPTLS
GLASALLERF GEQISRCLAV PQSQAQTLTT ITESVRRPEF SEAVSQTLVP TENPPLASTS
SESHSVTETV SEAATAMTST SASRDDIAVI GLSCRFPGAD SPEQFWQNIC DGRDLVSAVP
EARFASGHKQ HYAGLVEELE HFDPEFFKIT GREAILMDPQ HRLLMELSWQ AIEHAGYHPK
NLSHSRTGVF IGITLHDHLQ RLYQSGQPPV SHLATGNVHC LAANRISYLF NFNGPSEAVD
TACSSSLVAL NRAVKAMRDG ECDTALVGGA NALLSDVMFN AFSEAGMLSK TGKCHTFSAH
ADGYVRGEGG GMVLLKPLSQ AIAANDHIHA IIKGTAVNHG GHGQSLTAPS ASAQARVIRQ
ALEDARVSPS AIGYIEAHGT GTQLGDPIEL EGLRQVYGGA PMQPPAYIGT VKTNIGHLES
AAGMAGLIKV IMALKAQWLP KSLHGQPVNK LVNPAEQPFT FLPDGTAWQA RVDEQQHPLP
LRAGVSSFGF GGVNAHVIVE QAAAPTVITE TPVGNQLVLV SAVTETLLRA QLTELQALIP
TLKDADLPAL ALTSRHGRGG YRYRAAYVVS SLAQLSDAIG RTLAADSLGS GESHIARHDD
ASVDLKTLVQ MADWQLLAAR WQAGENIHWP DIEEPGAYRK MPFPLTRFNR RPCTISQLQP
AVAGIVNPTP LQGDIRFFAP VWQPQTLTAS VSNSRKTVLL LVPETEVLAW STRMDDRVAH
DWYVIRFAGL MPRLSKRELE IDVWAEQAFD DLLAMCAERH LQPDWIVDVC DFGPDSDSQW
QARIRFLQLC VRAWSRSGLA LFQISDRQSS RTRQWFTALY AGLAAEYRQI SCRSVVFDQA
PPFTELEPLL ERELQGGDSR PVSICDGQRQ ILSYQLCNLP QAGQIRGLDS EAAYLVTGGL
GGLGLQAATL LRQLGAKHLI LLGRRQPDET RSQQLQMLSN GSAQIEYFHD LSTLAERLQQ
QPVRIAGVIH CAGIDTQGEL AFVNKPVSAF TDCLAPKVVL AEQLVSRLTP HLDPAALTFF
IAFSSVSTVV PALTAGRSDY GPANAALDQW VATMAGQYPQ SGFVSVQWPS HQQGGMPVVV
SDVYRDTGLA NLTREQSDDI LKILITLALQ GRLSHSTLLP HVGDGSPVLF SKDVFEPAIK
VPGEIPRPDS KGHHEAAART LILTRLTALF ARQLLVDESA LQAGVPFDEL GIDSILIADL
VRAIESEFDC ILPPSAILEY PSLGQLTEYL GELVEIDMPD TPAEPQVSST SQTSARTIAA
TATTRVPGAD NGEDKVAVIG MACRFPGAES VTRFWHNLEQ GICSVTEVPE QRFDMGRIYA
PVQQPGKSIS KWGGFIDGVD LFDPEYFSIP QEQAAYIDPL TRLSLMVATE AIADAGYTRE
DIWGRRCGVY MGGNRGHYGL NHVDQAATAT GLNQNFIAAH LAHIFNLTGP CYVMDAACAS
SLLSVHSAVR DLLHGDVDLA LAGGVEVLLD ETPYLKLSAA GALSPDGLCQ TFSRHANGFV
PGEGAGTVVL KRLSQAQQDG DSIYAVIEAS EVNNDGHTMG LTTPNIEAQK ALLERVYGHR
NDVSGHLRYI EAHGTGTMIG DPIELKAMAS VFAGLNIPTA QVAVGSVKSN LGHLMGAAGI
ASFIKTALIV KHRRIPPTLH CDEPNPRFNF STSPLVPANI ASDLRGSGQP LLAGISAFGF
GGTNCHICLS NDYVAAAATR KPQPAPQFNL RSFWLKGKNA PVVGRTENTG ETASKITQAN
TILELEWL
//