ID   A0A0C5WK40_9FLAO        Unreviewed;       913 AA.
AC   A0A0C5WK40;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE            EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN   ORFNames=AW14_05140 {ECO:0000313|EMBL:AJR03115.1};
OS   Siansivirga zeaxanthinifaciens CC-SAMT-1.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Siansivirga.
OX   NCBI_TaxID=1454006 {ECO:0000313|EMBL:AJR03115.1, ECO:0000313|Proteomes:UP000032229};
RN   [1] {ECO:0000313|EMBL:AJR03115.1, ECO:0000313|Proteomes:UP000032229}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CC-SAMT-1 {ECO:0000313|EMBL:AJR03115.1,
RC   ECO:0000313|Proteomes:UP000032229};
RA   Young C.-C., Hameed A., Huang H.-C., Shahina M.;
RL   Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; CP007202; AJR03115.1; -; Genomic_DNA.
DR   RefSeq; WP_044637818.1; NZ_CP007202.1.
DR   AlphaFoldDB; A0A0C5WK40; -.
DR   STRING; 1454006.AW14_05140; -.
DR   KEGG; sze:AW14_05140; -.
DR   PATRIC; fig|1454006.5.peg.1008; -.
DR   HOGENOM; CLU_004709_1_0_10; -.
DR   OrthoDB; 9759785at2; -.
DR   Proteomes; UP000032229; Chromosome.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032229};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          578..771
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   913 AA;  104002 MW;  C2B36D806C717559 CRC64;
     MDKFSFLNAA HTAYFADLYD QYLQNPDSVE PSWRAFFQGY DFGSENYGFE GEIVEGVSAQ
     MPEYLQKEFQ VIKLIDGYRM RGHLFTKTNP VRDRRTYEPT LDIENFGLSA NDLDTVFNAG
     EILGIGAKPL REILVHLNKI YCSSIGVEYM YLRNPEVISW WQGKLNHNDN QPSFSATKKK
     YILSKLNQAV TFENFLQTKY VGQKRFSLEG GESLIPAISN VLFVAAEKYD VKECVLGMAH
     RGRLSTLVNI FRKPVNELFS EFDGKDFEDA DIDGDVKYHL GLTLDKTYQN GKNIKMNLVP
     NPSHLETVAS VAEGITRAKI DTDYNGDDQK IIPIIVHGDA AIAGQGIVYE VAQMSQLNGY
     KTGGTVHIVV NNQIGFTTNY LDARSSTYCT DVAKVTLSPV LHVNADDAEA VVHAVELALE
     YRMRYKKDVY IDLLGYRKYG HNEGDEPRFT QPKLYKAIAK HKNPFEIYSS KLISEKTIDK
     DYVDAIVEEF KSTLEAEYIK SKEADSSKVR EFMQERWQGF EREDLEGMLK PVDTSYPKEN
     LENISKVVST VPKDVKFVRK AERILEGRAK MVFETDTLDW GMAETLAYGS LLEEGFNVRI
     SGQDVERGTF SHRHAILRDE ISEERVNLLN LNPHNKGKMD IFNSFLSEYG VLGFDYGYAM
     ANPNTLTIWE AQFGDFSNGA QIIFDQYLSA AEDKWKSQNG IVVLLPHGYE GQGSEHSSAR
     IERYLQLCGD DNMTVADCTT PANMYHLLRR QMLRKFRKPL IVFTPKSLLR HPKAVSSISE
     LASGEFQEVI DDTINPENVK KLVLCTGKFY YDLLAEREEL GREDIALVRI EQLFPLHIDK
     IQAAINRYPN VEKYVWAQEE PRNMGAWSYL TQRLDIVKLE GITRPYNSVP APGSGTRDKS
     RQRRVINAVF ENN
//