ID   A0A0C9LWS6_9FUNG        Unreviewed;      1217 AA.
AC   A0A0C9LWS6;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 43.
DE   RecName: Full=Ras GEF {ECO:0008006|Google:ProtNLM};
GN   ORFNames=MAM1_0239c08562 {ECO:0000313|EMBL:GAN09040.1};
OS   Mucor ambiguus.
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=91626 {ECO:0000313|EMBL:GAN09040.1};
RN   [1] {ECO:0000313|EMBL:GAN09040.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NBRC 6742 {ECO:0000313|EMBL:GAN09040.1};
RA   Takeda I., Yamane N., Morita T., Tamano K., Machida M., Baker S., Koike H.;
RT   "Draft genome sequence of an oleaginous Mucoromycotina fungus Mucor
RT   ambiguus NBRC6742.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; DF836528; GAN09040.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C9LWS6; -.
DR   STRING; 91626.A0A0C9LWS6; -.
DR   OrthoDB; 5476208at2759; -.
DR   Proteomes; UP000053815; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd06224; REM; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR   InterPro; IPR008937; Ras-like_GEF.
DR   InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   PANTHER; PTHR23113:SF364; GUANINE NUCLEOTIDE EXCHANGE FACTOR LTE1; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00618; RasGEF_N; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00229; RasGEFN; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50212; RASGEF_NTER; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW   ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053815}.
FT   DOMAIN          255..375
FT                   /note="N-terminal Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50212"
FT   DOMAIN          875..1208
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
FT   REGION          63..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          139..162
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..217
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          465..512
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          550..613
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          791..832
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        593..613
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        815..832
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1217 AA;  137029 MW;  F31391A8C823C4FC CRC64;
     MSSAAVETTP RKRNNSIIPL EFRNDTSDGG MERAALATVF GVREYTESKI FWNADEEPAQ
     DITTTTTTTP TTTSILQRNT SRKSYTTTSH RGSTIMMQTS GVSPSSLPPA PPVHCSLPKI
     PIVSEFGDIW SDTDFAAASD SKTPTTAATQ SNTAQHPFQL SPPTDLSDFP LTIFDLLASD
     ENPNLILWGI NAKQHSTIPS TAPSTADERD DSTPHNKKTL RWSAQQLISL KNLKKKASVD
     LSNAVAVPKP PTPEADCVIE AATIEKLVEI LTISLDYAFM TDFFLIYRVF MTPLQLCKLL
     ILRFNWSLEK NEAKRCIVRI RTFVVMRHWL LNYFLRDFIP SKELRIVLTD FLNAMPYHPL
     IKQSPRDQRI IKGLKRVVRR LKKIYYASNA STRVQVIGPP PPTYEQQVVK QMVKDQLTSS
     STIRQKTLNM VNGVHLDARH SNNTAVKHAQ AAAPNVVVIG NYPSASTHQQ QQQHRSNSYI
     EQRSCRRRGS SVSSTITSNK FNNGSSLPNS MYNLQDTVNN SASMEWINIQ QQQQLNSSKS
     QDFYISNFSD NSLESTISPG TSDEEGSDDE QDDVSAPSPK SYHSKELDEP AAAASEQQQQ
     YAVSCSPPTA LNSSNELTEK LEIVRQQQQQ EEEQERQQAE RFLTSYSTNP TEATAAILSN
     TVSDYTIRTR SFYSAQLAIP STISTPDIYH PPAANANSYF DTSHANHSHK NLISSTSYNS
     MAYPSVTDSE VVTPACAISG DPATLVPRSR FSNYNLQQQP NRMSKTFVNM DPKSKPLPPL
     VLLQDEKESS MTSASSIASS NKHMRQHQHE GKTEAWRLST TSNKQQQQPT LRAPKSRIFE
     IDIDTNRNNE FLSSLPPSIP MPMFTIYRSV VLSYSTSLMA QQFCLIERAV LLDIDWEELV
     DCRWTKMSVT TLYQPPSMED VDQDVANTMA FDQHPQGIYS RTKRMKQQHE RNKDGVERGV
     EKTINRFNAV CQWVSSEIVQ TRQLDQRVKL IEKFIRLAKK CKLYCNFSTL IQILLGLQSS
     SVSRLEKTWP LVNKREIKTL QELSTFTSPT KNWKHIRDSM SQVAEEYGES PTEIQVEVDD
     NNSTFRKRKS KKSVTIKLPF GGCIPFLGIY LSDLVFNAEL PSYLPSSNNN IERKHQGSID
     AVLSQPLVHF RKHRITATVI KRVLVFQNLA KRYSFEESSD LLLFNTCFQV TSLDTEAIQK
     ASYAIEPPSL AGGIVYH
//