ID A0A0C9M6Z6_9FUNG Unreviewed; 864 AA.
AC A0A0C9M6Z6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Lysophospholipase {ECO:0000256|RuleBase:RU362103};
DE EC=3.1.1.5 {ECO:0000256|RuleBase:RU362103};
GN ORFNames=MAM1_0099d05195 {ECO:0000313|EMBL:GAN05721.1};
OS Mucor ambiguus.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX NCBI_TaxID=91626 {ECO:0000313|EMBL:GAN05721.1};
RN [1] {ECO:0000313|EMBL:GAN05721.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NBRC 6742 {ECO:0000313|EMBL:GAN05721.1};
RA Takeda I., Yamane N., Morita T., Tamano K., Machida M., Baker S., Koike H.;
RT "Draft genome sequence of an oleaginous Mucoromycotina fungus Mucor
RT ambiguus NBRC6742.";
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a fatty acid +
CC H(+) + sn-glycerol 3-phosphocholine; Xref=Rhea:RHEA:15177,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16870,
CC ChEBI:CHEBI:28868, ChEBI:CHEBI:58168; EC=3.1.1.5;
CC Evidence={ECO:0000256|RuleBase:RU362103};
CC -!- SIMILARITY: Belongs to the lysophospholipase family.
CC {ECO:0000256|ARBA:ARBA00008780, ECO:0000256|RuleBase:RU362103}.
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DR EMBL; DF836388; GAN05721.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0C9M6Z6; -.
DR STRING; 91626.A0A0C9M6Z6; -.
DR OrthoDB; 1997175at2759; -.
DR Proteomes; UP000053815; Unassembled WGS sequence.
DR GO; GO:0004622; F:lysophospholipase activity; IEA:UniProtKB-EC.
DR GO; GO:0102545; F:phosphatidyl phospholipase B activity; IEA:UniProtKB-EC.
DR GO; GO:0009395; P:phospholipid catabolic process; IEA:InterPro.
DR Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR002642; LysoPLipase_cat_dom.
DR PANTHER; PTHR10728; CYTOSOLIC PHOSPHOLIPASE A2; 1.
DR PANTHER; PTHR10728:SF40; LYSOPHOSPHOLIPASE; 1.
DR Pfam; PF01735; PLA2_B; 2.
DR SMART; SM00022; PLAc; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 2.
DR PROSITE; PS51210; PLA2C; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid degradation {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Lipid metabolism {ECO:0000256|PROSITE-ProRule:PRU00555,
KW ECO:0000256|RuleBase:RU362103};
KW Reference proteome {ECO:0000313|Proteomes:UP000053815}.
FT DOMAIN 161..864
FT /note="PLA2c"
FT /evidence="ECO:0000259|PROSITE:PS51210"
FT REGION 344..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 702..744
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 759..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..497
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 864 AA; 97166 MW; BD72CEE9740904F2 CRC64;
MGKGVTSSIS TRSKVALVTL ISVSVLGSVY YSKYKHNKSN KRKSIDLADK KLAATIDDNS
LYNDFVASLP SSLNLIDDSA DNFLSSLFNS SYSPSDYIPG FIPTSIEELK EQMASLYPSF
ESQFETIREM YNSFWEFLSL EEFRNIVQES IQEDDDPEMH PEIEQDAYVR TGQALSEEEI
QFTEARKQKM RAAFAFFIGV DEHEVEIEDI PNIGIASSGG GYRAMVACSG YLHALNETGI
LDCVLYMAGV SGSTWAMSQF YSPLTNASVD TLKDHLSSRI HTHIANLSNF LTVLNASRHN
AKILLHGVVQ RYYQQNGSIS LVDIFGMLLG GTLLAKKVTV APPDKEKSDR IMENDAHSYT
ESIEDPSELG LKNKEDHTQP GTVHEDDGAE VKPRLLKKNE IKLSMQKDYF QDGSLPMPIY
CAVRHEVELA SVTKAATVSS KQGVEPCQKV DDGEEDEALE HVEADDAKSE DTEKETKDDG
GNEAEETDKK TEEDEEHQKE EAVEEEMNDL YQWFEFTPYD MGSEEINAWI PIWAFGRKFE
NGKNTERLPE QSLGILMGMF GSAFVASLAH FYQEIRLLLP TSAIEKADEM INNYQASVST
IHPISPASFP NPFYKMPTTV QDKDASQDKE EVLRSESLVE SELIGLMDAG MDNNLPFYPL
LRQGRDVDII LAIDLSADIQ EAPYFDRAEG YVKRRGIKGW PVGAGWPRKE EESHESEKSD
ADPVKVEHPK KPSAKDSKQQ EPKESKYALD TCTVFASSSS ETIPSSSDED ASTTITSYPE
NTNPITLVYF PLIVNENYDP EFDPQTAEFC STWNFVYSSE QVNKLHGLAE ANVKDNLEKV
RKVIKETWKR KRDERLRRES LPRI
//
