ID   A0A0C9N135_9FUNG        Unreviewed;      1222 AA.
AC   A0A0C9N135;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=RNA-dependent RNA polymerase {ECO:0000256|RuleBase:RU363098};
DE            EC=2.7.7.48 {ECO:0000256|RuleBase:RU363098};
GN   ORFNames=MAM1_0281d09188 {ECO:0000313|EMBL:GAN09657.1};
OS   Mucor ambiguus.
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Mucoraceae; Mucor.
OX   NCBI_TaxID=91626 {ECO:0000313|EMBL:GAN09657.1};
RN   [1] {ECO:0000313|EMBL:GAN09657.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=NBRC 6742 {ECO:0000313|EMBL:GAN09657.1};
RA   Takeda I., Yamane N., Morita T., Tamano K., Machida M., Baker S., Koike H.;
RT   "Draft genome sequence of an oleaginous Mucoromycotina fungus Mucor
RT   ambiguus NBRC6742.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000256|ARBA:ARBA00024517,
CC         ECO:0000256|RuleBase:RU363098};
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000256|ARBA:ARBA00005762,
CC       ECO:0000256|RuleBase:RU363098}.
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DR   EMBL; DF836570; GAN09657.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0C9N135; -.
DR   STRING; 91626.A0A0C9N135; -.
DR   OrthoDB; 5477883at2759; -.
DR   Proteomes; UP000053815; Unassembled WGS sequence.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-dependent RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:regulatory ncRNA-mediated gene silencing; IEA:UniProt.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; RNA-DEPENDENT RNA POLYMERASE; 1.
DR   PANTHER; PTHR23079:SF55; RNA-DIRECTED RNA POLYMERASE; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU363098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053815};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU363098};
KW   RNA-directed RNA polymerase {ECO:0000256|ARBA:ARBA00022484,
KW   ECO:0000256|RuleBase:RU363098};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU363098}.
FT   REGION          1151..1192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1154..1169
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1222 AA;  142261 MW;  21B8F384C51D5FD4 CRC64;
     MSLSSIANFE EDAYCYLISN LSPHTDRDTL WRVFGAFGTI TQLEIKLGQM SKAAIIYNSQ
     PSEYLFTQKT YILDRLVAVN PLPISEYIAD FSRAIPVHKL SLGGLETPRL FIEEWSTDQY
     VAFDLNLNDQ YIDIFFQHVD GYYRLRIVYD DNLRDNAILQ RYDNKSSLTL SGKYPAYFWK
     SKKPMEELGE TYHLSDWERV TDIPLDEFSR DMIRQKATAG TSQSKGPILP GGQYPNHNMK
     LSMWTVYRLE FDIPLSNKKG PTALLPTNVT HEAIEYKLRQ AIGGHQQPLA GQILVRPSTK
     TIDFERQIAD MAFEVQFMME HAFRLKILRE YNVDLGFFEK MRELPSQVSC VFLTLLSAPQ
     YRVYNPDTVI NHIYRLCKDH IGFQIPIPDN YTLTRRVLVT PTSVYPMQPT VEPMTHLQYH
     FREHADRFLY VQFTDEDLNP VAPQEDEEET SQNAKLFDRI YNILRRGLRI AGRTYEFLGT
     SIQDLRAHGC WFFASTPQVS RGQIMAWLGD FSEIKFISAF INCSGQSLTP RLMHLDIKGH
     DIEEVEDYMY NQHIFTTDCG KMSPQIAREI AKQLELDYTP SVIKFNLNGA RGILLLSNFL
     TKRKIQLRTS QIRFDSTRLS LEVIKYAKPN KLYLDQKSIL MLTSLGVKVY IFHELLDENM
     DYCEKYPNVD MMDMHYSKGR LDHFRQILDY KFQDKHDPFI TNLVSSYQNH VLRYLQQCQL
     YIHQGVKVFA AMDETGTLQP GEVFLQITDP SGLAANRKVI EGPCVIYRDS SCFPGDVRVM
     SAVNYSELRH YTNVLIFSSI DRRDLPSLCS NDDPDEDNFN RLPSVIWDTR LLPVKCNVAS
     RSYQTAMTPH QSKKISFREA AKFFTTYISR DTSRKLREAF VATADRRKDC VFNGDCIYLS
     LQMSRALDFA KTGIYATINN DLLQYPFPDF MRQRPLKTYT SSTPLGSIYR ATKRMYERPF
     SNTHCYYDTR LYVEDMYKYI VEARKTKAKY DYSLRILLGQ YSVKTEVEFI SGHIIEWPKY
     LNEQCRPQFL ERIEAAYIRF RKYWKQVFDS QWANDTHRSS TESQSAENEA KAAAWYYVTY
     HPSEFKSDTV YSKTLQRYMS FPWVVESYLV YIAHKNDSRP NLAKYGQPIS LEKIEDHARL
     HRGPQAEMIF AASDEDETSS EEEESDTGDE DPTSSNHQHA NSYGLDLPRH PQELDHQYHH
     DHDQEVDAVP VVTVKLADLL NL
//