ID A0A0C9WSR5_9AGAR Unreviewed; 5021 AA.
AC A0A0C9WSR5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN ORFNames=K443DRAFT_6566 {ECO:0000313|EMBL:KIK01905.1};
OS Laccaria amethystina LaAM-08-1.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Agaricineae; Hydnangiaceae; Laccaria.
OX NCBI_TaxID=1095629 {ECO:0000313|EMBL:KIK01905.1, ECO:0000313|Proteomes:UP000054477};
RN [1] {ECO:0000313|EMBL:KIK01905.1, ECO:0000313|Proteomes:UP000054477}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LaAM-08-1 {ECO:0000313|EMBL:KIK01905.1,
RC ECO:0000313|Proteomes:UP000054477};
RG DOE Joint Genome Institute;
RA Kuo A., Kohler A., Nagy L.G., Floudas D., Copeland A., Barry K.W.,
RA Cichocki N., Veneault-Fourrey C., LaButti K., Lindquist E.A., Lipzen A.,
RA Lundell T., Morin E., Murat C., Sun H., Tunlid A., Henrissat B.,
RA Grigoriev I.V., Hibbett D.S., Martin F., Nordberg H.P., Cantor M.N.,
RA Hua S.X.;
RL Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054477}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LaAM-08-1 {ECO:0000313|Proteomes:UP000054477};
RG DOE Joint Genome Institute;
RG Mycorrhizal Genomics Consortium;
RA Kohler A., Kuo A., Nagy L.G., Floudas D., Copeland A., Barry K.W.,
RA Cichocki N., Veneault-Fourrey C., LaButti K., Lindquist E.A., Lipzen A.,
RA Lundell T., Morin E., Murat C., Riley R., Ohm R., Sun H., Tunlid A.,
RA Henrissat B., Grigoriev I.V., Hibbett D.S., Martin F.;
RT "Evolutionary Origins and Diversification of the Mycorrhizal Mutualists.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
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DR EMBL; KN838600; KIK01905.1; -; Genomic_DNA.
DR STRING; 1095629.A0A0C9WSR5; -.
DR HOGENOM; CLU_000050_0_2_1; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000054477; Unassembled WGS sequence.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 7.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 2.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000054477}.
FT DOMAIN 4799..5018
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 787..813
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4163..4558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4570..4602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4644..4667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4678..4697
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4229..4257
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4274..4328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4329..4343
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4374..4409
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4416..4436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4467..4506
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4514..4550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4570..4587
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4645..4662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5021 AA; 561470 MW; 2EBAD04EE5287938 CRC64;
MSSTGAIHDP LEINLFRQTR HLLSIIPPES EYAEAVKNAS TTRELFTTLS RLLAVPAYTQ
LIATYYRPIL LDLCARWIEV DDSKEEQLVA LCLLLEVHEE LFPILYEILC ASFKEGPLSF
INETPSLMSI NVARLHWLLL AYYRILQANR ELPRQLSWSL APLSRATWTP HLDNAARLLS
IRCYALQSGM GEEERENLER EVLGEPCGVD CLLAYGQNED GSEKNVDGWI MPVIEVRRIQ
EERDSIVTKP HDYYTREDGD SAQVIQSSDL SSYIANIYGV LLLRTPRLLQ HESSLIPTPT
SIQGLQSLAL HVSLRIPTLV TSPPSAGKAL LLSHLAGLLH SSRNHIITIH LADTSLDPRA
LLGSYVSSTT RSGTFEWKEG VLVRSMREGK WVVFEDIDRG SSEVLGVIKP LVESLRAGKW
IGGCASLNIP SRGRVVAHHD FMIFATRSSL PSQHGIFPKP TFFGAHKFHE IVLQSPTTQE
LQTIIDSRFP RLAGSAAQAI IRLCNSVKRL GSSASAPEVG LRQVLKFCMR IDRLLPSSHR
PMCIVTDETS VPSFSAIFPN PTLREDVYLE ARDVFFGAGA STTSARVHVE AVANIIGEHL
GLDTDRRQWI LLGRTPEFQV EKDINGRTTA LCIGSTYLQA RQGKSEISPS IPRPFAMHKP
AILLLSRIAT AVALGEPVLL TGETGTGKTS VITHLATLLH RPLISLNLSH QTESSDLIGG
LKPVDARIPG SMLQEKFLEL FGATFSRRKN EKFEVKVRKA VNEAKWKRAV GLWKESTRLA
QERIRMKREQ ENRVGSRDTE LETPRKRRKV EQDMRTSSEE GWVSFLRDVE EFEVQHVHGK
GKFAFGFVEG PLVRALRLGE WILLDEINLA SPETLECISG LLHSPTASIT LSEQGSLEPV
PRHSDFRLFA CMNPATDVGK KDLPPNIRSR FTEIDVPPPD ADKETLLSII TQYVGPNVVG
DKGVIMNIAE FYVAVKELSA KRQIADGANH RPHFSMRTLA RALTFAADTA SSYSFRRSVW
EGCLMGFTMV LDSASAELVT SLARKHLLVG VRNPKSMLTK DPNPPSPPDS YVKFGPFYLE
KGPLPEDPVD NYIMTPSVHR KLIDLARIIL TRRFPILIEG PTSSGKTSSV EYLAKRTGHH
FVRINNHDHT DIQEYIGSYV SDPLTGKLVF KDGLLVQALR NGHWIVLDEL NLAPTDVLEA
LNRLLDDNRE LVIPETQEVV RPHPHFMIFA TQNPPGLYAG RKVLSRAFRS RFLEVHFEDV
PQTELETILC QRCQIAPSYG KKIVSVFHEL QKRRQAGRVF ESKQGFATLR DLFRWAGRDA
VGYQELAENG YMLLAERTRR DDDKVVVKEV IESIMGVKID EAVMYNLQRP DVDMLSYLGC
PTPFSSAIVW TKAMQRLFVL TCRALKFNEP VLLVGETSSG KTSVCQVYAD ITSQHLHGIN
CHQNTETADL IGGLRPVRNR HAAETKAMEE AVSALQGEGI SNIPLTFEAI SHALVQALKD
TSGLTTQARS HLEGIYQRVS HIQSIFEWQD GPLIHSMRNG DVFLLDEISL ADDSVLERLN
SVLEPDRTIV LAERGGANFE LPTIQASTNF KLVATMNPGG DYGKKELSPA LRNRFTEIWV
PRVDDRDDLE LIVGSLWQHE HLRKFTTSIL DFVDWLCMYV NDRSLISLRD ILAWVTFTNA
SYRSETLACI PADEIYHHAA HMTYLDGLSS LPQLSGYSSE ALMRLRQDAL TKLLELVPLQ
ESFSSTVPIH DQEQSVQFGS FAIKTGARLR GRQSFNLTAP TSKDNAMRVV RAFQVSKPIL
LEGSPGVGKT SLVTALADVS GHHLCRINLS DQTDLIDLFG SDLPVEGGSP GEFAWKDAEF
LKALQEGHWV LLDEMNLAPQ AVLEGLNAVL DHRGTVYIPE LGRTFTCHPS FRIFAAQNPL
NQGGGRKGLP KSFVNRFTKV YIQELSPDDL FIVCQHLFPD IEEETLRSMI SYNIQLNQQV
SLQRTFAREG SPWEFNLRDV IRWGILLSAS HPRKPLAYLR SVYLHRFRTM RDRSEAQRIF
NAVFSANSCE AEDAPGWTIS TTHIQIGHAI LKRRNMAPHR RPGRVLKSQL SALESLGNCI
SKSWLAILTG ERESGKTDLV RTLAGLSGNS VWEVSINSAT DTMDLLGSFE QVDIRGRILS
VVDEVADAVD HNLRTISGSK LSPSIQKHVL YLQQIRAKTA ASDIRDLLRA ASLLLFELIK
SSSDRGDRYL VLQGKVQDLS LASDATCRFE WVDGPLIRAM KEGQWLLMDD ANLCSPSVLD
RLNSLCEPDG CLTLSERGFV SGEVQIIKPH PNFRLFMSVD PHYGELSRAM RNRGMEIALL
SGLATDDCVI LCDHLRLPLS YATLGKPSSQ LVLFDATRRG LLAKNACGLR SIASTGRSLD
QHSALSSLVD HAPMLALSAL AEPLDSIVFF LCRCLIPDYI VHFNRHLEAF RESNGLASVL
QNLLKTFPSA ALSRVLSQFR ATLSSQNGVP SSFVLAQPID FHLNSPVFED TVNGPSSHDA
IVSALDLSAL LFLNELDQRS WTIPDILAVN GMGQSALKQI EEILEAIQSV GYQTLEALVV
EPASKLVDAK VAIAVLTYGR HLRRAVDAGA FDFSAVHAIL GWLKDSLDNY PPSFGPLFIA
VQTLNEIVSL SAGFGLIDMW SNFYMRSLPA TVRAELKKVE EFSCHMEECT RSLALRSEAF
KVMALVALTT VETQDTHVSE IVDLKTILEH CLLASHLPQT HLEYHINPQS LILELSALTG
CHHDSQLHML KDVINLACEN MRVPLLRLVP YQHLLWTLET RKENSSLAVQ TQISYLEGFW
SGRSSDCFGA LPLFQPTQLH AAISACDLAS VPLIRLDNYE KEVRRQVRIA IFHCKSDRSR
LGQLQRLFYQ SLITIITCFS SSYSLDVYEN ICQRSLVIQL DSIGGLLSLL EQSSNLPLVA
AIIKFLRPLL DQWSDRDPIS NLGLCWIALS QLLFDLLIPN TPVDPAAIQM CTVDRLRQDE
AVLLSQMQLH RQLEELTTGN RNNGILVHLE NCREDICAQL NNVPALPSRK NVIRLHQFWS
EVSQFRSSVT SAPRVDSILE LAKNGDSIAI PRERVIQESL ASFYQRLDSA YDEFADINIL
LKLGILQLRL GLHLVVQNSR ISQTRKDPTS RLVSSLVAFP SVRSATLILA TSTTAGQSRT
SAFRHILLGL AAISMEKFIG IEMAQQTQLV ESYYEQAFRL WLIDRTKDKE MDEASQSLYR
HTTLEHDAVG DAELEEQEFL SLFPAFEEIL EQPPLTNTQP KSQQPEFVLD PEMPLLVAIH
HDLLMHPQTA NSSTSLQHCK FDRIRQSMVE SLVRSHLGGL PESLDIESLH FQLSLLRNQS
TDLQRSQIIN DVPYNFYLDP NVQEVRKVAL VVGALRGRLQ VLSEEWPDQM VLRHLADRCD
VVLNFGLHSP VALVLSAIEQ LLLQTDDWEM YANRQNTIQV HREALIALIV DWRRLELSCW
QTLLDSEANK STDGVSKWWF QLYDVILRGA LSTLDQSTES TAFTQYLHNL LPLLEDFIIK
SPLGEFLARM QLLRSFEHFL AYIGSDKSDP QRSALQRIER ILHSIHQYYS LFSSEILTHL
SEKKAALEKE IRDFIKLASW KDVNVQALKQ SAQRTHRHLY KIIRKFREVL RQLISNFIQP
QLAGIPETVP LHFQSLSFEQ TWALSPPNND PNATPNHSHL LNKTFAKYCH LVATKIKPFV
QSLSAREVDN FAVEVITTTR KLASLSVPEG LEADKREKYH KGLLVRKRKA WSDLLKELKK
AGLSSNLKPD VLAQNMDPIW IRTQPPLSAT DPQTILVENY FDKLSGSLPA LRSSISNHHV
DLTTRELQRG IMFVESGFFM AMDLRSRLAN ALDVHQRLQR VASRLRTLSS SATVVTGSNL
SHYISCIKAF LCRLSSALSD LQRGAVSLNE LAPKINIADV LLEEISLFLR ESDSLKAKIM
YLPDSVRLTV MPVLLQDEHT LVSEAWAHIS RTAGLLSKWS KDDPRLNHLL LPITQWLETQ
DVPALLPPTT GSSSSYDCTE QLINSFLISV QSLLPHCRDV VSEEDEQDQE EQYLLKGYRQ
IRDFTHLLSI DRVFSALTSF LCLIKTQDDL RLNLPKIVPF FDVYLSLAND QLVAHNHWTK
ALLKLDFILS SVMHTLSRQG FCKPPDSDDA GTNGEASEVA GGVGLGDGAG TENVSKEIED
ESQVEGLQSE TLENQDPQGK HDEGDAIEMN DDFGGDLEDM LDNGSENEAE PSEGSEGDPD
ETLGNLDASD PSLVDEKLWG DEIGPDDPKC DEEQADQDHS KQHGGNSDVV AKEEKGRKES
KEKEGEQETD DATMEEEPGS EGECDSANDQ NVSGAPMDDY IPEANTLDLP DNMELGEDGV
ESGGEDKEDE MGMEDGEDEN TEDDDLRPEV EGATDQNSAP DDSFESPEVQ NDSTAGNPDE
NEDDREVEEG KEVVAKPDIF AGEGTAAEQD QSANPDVGES TTTGEMGTSE SRIGQSSTAQ
NETVNEEGHS ESLKPQIDPQ TVEPNAGGGS ATFGSQGGQA SSQSDEPQAS NPLRDLGDTL
KEIRQRINEI LNADEDQAPR ERIDVGDGQS QLEYLRPQDA DNDMQALGPA GEEQVAKLDQ
LKLIDDDMAV DNITAMDIDT PAAPEQHEQP TQESVFQQDP SSSTRRDDVE GAVLQTMNNR
FPETSVFPDS STSKADIEMG DTTDHTVEME LRNWRATDYP DDGAERIWRL YESLTHDLAY
ALCEQLRLIL EPTLATRLKG DYRTGKRLNM KKIISYIASD YTKDKIWLRR TKPSQREYQV
FIALDDSRSM AESHSIHLAY ETLALISKAL GRLEAGDIAI AKFGETVDIL HGFDEGPFTD
QAGTKIISAF RFNQKATDVL SLVDTSLKVL ERARERRSMS SSSGADLWQL EIIISDGMCQ
DHEKLRTVLR RAEEQRVMIV FIILDSLHAT AGDYSTQQHG SSILLMDKPE FRMVDGRMEV
QLQKYLDSFP FEYYVVLRNV EALPEVLSGT LKQFFERISE E
//
