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Database: UniProt
Entry: A0A0D0GSK2_9SPHI
LinkDB: A0A0D0GSK2_9SPHI
Original site: A0A0D0GSK2_9SPHI 
ID   A0A0D0GSK2_9SPHI        Unreviewed;       478 AA.
AC   A0A0D0GSK2;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   25-OCT-2017, entry version 23.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=TH53_09725 {ECO:0000313|EMBL:KIO77391.1};
OS   Pedobacter lusitanus.
OC   Bacteria; Bacteroidetes; Sphingobacteriia; Sphingobacteriales;
OC   Sphingobacteriaceae; Pedobacter.
OX   NCBI_TaxID=1503925 {ECO:0000313|EMBL:KIO77391.1, ECO:0000313|Proteomes:UP000032049};
RN   [1] {ECO:0000313|EMBL:KIO77391.1, ECO:0000313|Proteomes:UP000032049}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NL19 {ECO:0000313|EMBL:KIO77391.1,
RC   ECO:0000313|Proteomes:UP000032049};
RA   Santos T., Caetano T., Covas C., Cruz A., Mendo S.;
RT   "Draft genome sequence of Pedobacter sp. NL19 isolated from sludge of
RT   an effluent treatment pond in an abandoned uranium mine.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KIO77391.1}.
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DR   EMBL; JXRA01000036; KIO77391.1; -; Genomic_DNA.
DR   RefSeq; WP_041881209.1; NZ_JXRA01000036.1.
DR   EnsemblBacteria; KIO77391; KIO77391; TH53_09725.
DR   Proteomes; UP000032049; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000032049};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895}.
FT   DOMAIN      174    304       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      385    454       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     182    189       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   478 AA;  53801 MW;  814925C2C667F5E6 CRC64;
     MQNTCTTVWN NSLQTIKANI PNQSYKTWFE PISALKLEGN VLTVQVPSLF FYEWLEEHYV
     GLLRKTVKQE LGDEGRLEYN IVVDNKPSKS NTPYIAASSP SNTNTIASKA QSLPAPAQIS
     KDLRNPFVIP GLKKLNVDPQ LNANYTLENY IEGDCNRLAR SAGFAVAAKP GATSFNPLMI
     YGAVGLGKTH LAQAIGNEIK RTYPDKLVIF VSCEKFCQQF VESLKNNTIN DFVNFYQAMD
     VIIMDDIHNF AGKEKTQDIF FHIFNHLHQS GKQIIITSDK APKDLSGLEE RLLSRFKWGL
     SADLQIPDLE TRIAILRKKM ASDGIDLPAE VIEYVAHNID NNVRELEGAM VSLLAQATLN
     RKEIDLSLAK SMLKNFIKNT SKEISMEYIQ KLVCEYFEVP VDLVKSPTRK REVVQARQIS
     MYLSKSLTKS SLKSIGAFYG GRDHSTVIYA CQTVEDLIDS DKKFKGYVTD IQKKLKMS
//
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