ID A0A0D0NWH1_KITGR Unreviewed; 1060 AA.
AC A0A0D0NWH1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN ORFNames=TR51_33670 {ECO:0000313|EMBL:KIQ63571.1};
OS Kitasatospora griseola (Streptomyces griseolosporeus).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Kitasatospora.
OX NCBI_TaxID=2064 {ECO:0000313|EMBL:KIQ63571.1, ECO:0000313|Proteomes:UP000032066};
RN [1] {ECO:0000313|EMBL:KIQ63571.1, ECO:0000313|Proteomes:UP000032066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MF730-N6 {ECO:0000313|EMBL:KIQ63571.1,
RC ECO:0000313|Proteomes:UP000032066};
RA Arens J.C., Haltli B., Kerr R.G.;
RT "Draft genome sequence of Kitasatospora griseola MF730-N6, a bafilomycin,
RT terpentecin and satosporin producer.";
RL Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIQ63571.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JXZB01000004; KIQ63571.1; -; Genomic_DNA.
DR RefSeq; WP_043915935.1; NZ_JXZB01000004.1.
DR AlphaFoldDB; A0A0D0NWH1; -.
DR STRING; 2064.TR51_33670; -.
DR PATRIC; fig|2064.6.peg.7124; -.
DR OrthoDB; 4812256at2; -.
DR Proteomes; UP000032066; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.90.320.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR011335; Restrct_endonuc-II-like.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52980; Restriction endonuclease-like; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000032066}.
FT DOMAIN 19..342
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 343..653
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 40..47
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1060 AA; 115058 MW; A6071C99CB4575A7 CRC64;
MSSTEPLNHP AQLRELLGIP FNAEQLAAIG APMAPGVIVA GAGSGKTTVM AARVVWLVGS
GAVRPEQVLG LTFTNKAAGE LAERVRASLL RAGVREDDAL GDPQISTYHA FAGTLLKEHG
LRLGIEPDVR LLADATRFQL AARVLRQARG PYPALTGTFS SLVAELIALD SELAEHLVEP
SRLRDWDEQL LDELAVLKLS NDDLRAVPKA ARGRQELLHL VEDYRARKQK LGLLDFGDQI
AASARLAQQR PEVGRLLREQ YRVVLLDEYQ DTSVAQRLML AGLFGGSGSA GHPVTAVGDP
CQAIYGWRGA SVANLDDFPH HFPQADGSPA HRFALSENRR SGGRLLAFAN ELAAPLREMH
EGVEALRPAP GAELDGFVRA ALLPTHAEEV DWLADSIAHL VRTGTAPGRI AVLCRAGAAF
PDIHAALVAR SVPVEVVGLG GLLQLPEVAD LVAVCEVLQD PTANAALVRL LIGPRWRIGP
RDLALLGRRA ADLVRTARLG DQDPLAAAVA ETDPTEVVSL ADALETFVDA EQPDELPFSP
EARVRFARFA REIRDLRRTL AEPLMDVLHR VLAVTGLEVE LSASPLALAA RRRETLHSFL
DIAASFADLD GDPGLAAFLA FLRAAQEYER GLDAGLPGGE DTVKVLTAHK SKGLEWDVVA
VPGLVKGGFP SGQGRERWTS TRKVLPHALR GDAATLPADP AWNAKGMGLF KKEMAHHAEV
EELRLGYVAF TRPRSLLLAS GHWWGPSQKR RRGPSDFLLK LRAHAERPGN GEVERWAEAP
ADDAQNPAFD VSVETPWPLP LDPSAQHARR RVADVVRHRL AGAPAAEPEQ LGVEDQRLVA
SWDRDLTALL GELERSRRTV REVELPASLS ATELMRLAAD PDGFARELAR PMPRPPAPAA
RRGTRFHAWV QARFDQPLLL GPDALPGLDA EEIEDERDLE RLKEAFLRGP YAGRTPYRVE
APFQLVLAGR VVRGRIDAVY RDADGGAGSP RYEVVDWKTG REDSGDPLQL AVYRLAWAEQ
AGVPVEQVTA SFCYVRSGRI ETPSGLPGRK ELSDLLIGNR
//