ID A0A0D0V449_9ACTN Unreviewed; 491 AA.
AC A0A0D0V449;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:KIR65677.1};
GN ORFNames=TK50_09980 {ECO:0000313|EMBL:KIR65677.1};
OS Micromonospora haikouensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=686309 {ECO:0000313|EMBL:KIR65677.1, ECO:0000313|Proteomes:UP000032254};
RN [1] {ECO:0000313|EMBL:KIR65677.1, ECO:0000313|Proteomes:UP000032254}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JXNU-1 {ECO:0000313|EMBL:KIR65677.1,
RC ECO:0000313|Proteomes:UP000032254};
RA Long Z., Huang Y., Jiang Y.;
RT "Sequencing and annotation of Micromonospora carbonacea strain JXNU-1
RT genome.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIR65677.1}.
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DR EMBL; JXSX01000001; KIR65677.1; -; Genomic_DNA.
DR RefSeq; WP_043962485.1; NZ_JXSX01000001.1.
DR AlphaFoldDB; A0A0D0V449; -.
DR PATRIC; fig|47853.6.peg.2124; -.
DR OrthoDB; 9805787at2; -.
DR Proteomes; UP000032254; Unassembled WGS sequence.
DR GO; GO:0004470; F:malic enzyme activity; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05311; NAD_bind_2_malic_enz; 1.
DR Gene3D; 3.40.50.10380; Malic enzyme, N-terminal domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR012301; Malic_N_dom.
DR InterPro; IPR037062; Malic_N_dom_sf.
DR InterPro; IPR012302; Malic_NAD-bd.
DR InterPro; IPR045213; Malic_NAD-bd_bact_type.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43237; NADP-DEPENDENT MALIC ENZYME; 1.
DR PANTHER; PTHR43237:SF4; NADP-DEPENDENT MALIC ENZYME; 1.
DR Pfam; PF00390; malic; 1.
DR Pfam; PF03949; Malic_M; 1.
DR SMART; SM01274; malic; 1.
DR SMART; SM00919; Malic_M; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000032254}.
FT DOMAIN 95..228
FT /note="Malic enzyme N-terminal"
FT /evidence="ECO:0000259|SMART:SM01274"
FT DOMAIN 240..462
FT /note="Malic enzyme NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00919"
FT REGION 462..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 50746 MW; F0BD891745F987E6 CRC64;
MAITRLPSAG FSITIRISVP ADASSIGRLT TSVGEAGAIV TALDVVDSDP THVLVDLTCD
TADAGHADQV VDALTALDGV DVRKVSDRTF LLHLGGKIEV SSKVALRNRD ELSRAYTPGV
ARVCMAIAEN PADARRLTIK RNTVAVVSDG SAVLGLGNLG PAASLPVMEG KAALFKRFGG
VDAWPVVLDT QDTDEIVAIV KAIAPAYGGI NLEDIAAPRC FEIEARLRAA LDIPVFHDDQ
HGTAICVLAA LTNALRVVGK QLADVRVVVS GAGAAGTAIM KLLLRQGVGD IIAYDRQGAL
HRGLTGLNPA WQWLAENTNK ENYSGDLAGA VRGADVFIGV SAPNLLTGDD IATMAKDAIV
FALANPDPEV DPREARKHAA VVATGRSDQP NQINNVLAFP GVFRGMLDAH AEEFTEEMAI
AAARAIADVV GEDKINPTVI VPSVFDSRVA PAVAAAVRAA AQTPAAATPP PAADPGPADL
PEIAATASAT P
//
