ID A0A0D0Y6E5_9LACO Unreviewed; 665 AA.
AC A0A0D0Y6E5;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Ribosome protection-type tetracycline resistance-like protein {ECO:0000313|EMBL:KIS03848.1};
GN ORFNames=WDC_0589 {ECO:0000313|EMBL:KIS03848.1};
OS Paucilactobacillus wasatchensis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Paucilactobacillus.
OX NCBI_TaxID=1335616 {ECO:0000313|EMBL:KIS03848.1, ECO:0000313|Proteomes:UP000032279};
RN [1] {ECO:0000313|EMBL:KIS03848.1, ECO:0000313|Proteomes:UP000032279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WDC04 {ECO:0000313|EMBL:KIS03848.1,
RC ECO:0000313|Proteomes:UP000032279};
RA Oberg C.J., Culumber M., McMahon D.J., Broadbent J.R., Oberg T.S.,
RA Ortaki F.;
RT "Lactobacillus wasatchii sp. WDC04, a late gas producing bacteria isolated
RT from aged chedder cheese.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Abolishes the inhibitory effect of tetracyclin on protein
CC synthesis by a non-covalent modification of the ribosomes.
CC {ECO:0000256|ARBA:ARBA00003987}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIS03848.1}.
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DR EMBL; AWTT01000009; KIS03848.1; -; Genomic_DNA.
DR RefSeq; WP_044010299.1; NZ_AWTT01000009.1.
DR AlphaFoldDB; A0A0D0Y6E5; -.
DR STRING; 1335616.WDC_0589; -.
DR PATRIC; fig|1335616.4.peg.590; -.
DR OrthoDB; 9801591at2; -.
DR Proteomes; UP000032279; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-KW.
DR CDD; cd03711; Tet_C; 1.
DR CDD; cd04168; TetM_like; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR035650; Tet_C.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR005517; Transl_elong_EFG/EF2_IV.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF03764; EFG_IV; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR PRINTS; PR01037; TCRTETOQM.
DR SMART; SM00838; EFG_C; 1.
DR SMART; SM00889; EFG_IV; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000032279}.
FT DOMAIN 1..240
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 665 AA; 73513 MW; E70880EA64B87B65 CRC64;
MKHIVTGIVA HVDAGKTTLS EAMLYRSGEL RQLGRVDNGD AFLDSDDLEK KRGITIFSHQ
ASLKYQDLAL TLLDTPGHVD FVAQTEQVLS VLDYAILVIS ATDGVQGYTR TLWHLLEQYH
VPVFIFVNKM DANSVKKKQI LAQLQSDLSQ GCIAFNPAST STNQQTTTDI PTESYDEIAV
CNDDVFEKFV DSGDIEDDTI RQMMRHREIF PCYFGSALKV TGVDALLAGI NRWTSAVAPK
QDFGAKVFKI SHDDKGERLT WVRVTGGMLH TKDVLVNGQK TNQLRLYNGA KFTISQEILA
GGVCAVTGLT DTYPGQGLGN ESDSVTPTIQ PVLNYALDTE DYDIHTCLTA LRQLEDEDPQ
LHVSWSSHLQ EIRVQIMGEV QLEILQQILL DRFNLAIEFG KGSILYKETI TKAVEGVGHF
EPLRHYAEVH LLLQPTASGS GITFTTDCSV DVLGRNWQHQ VLTNLNAKEH LGVLTGAPIT
DMQITLVGGR ASIVHSVGGD FKEATWRAVR QGLMTLKETC DCQLLEPWYQ FRLMIDQDQV
GRAMNDIQRM NGNFDAPDIS DSGSAMTVIT GTAPVSQMQD YAKEVNAYTH GQGQLECIVA
GYRPCHNADE VIAAAKYEPV ADLDNTPDSV FCAHGAGYPV SWDQLPQMAH CEYIYSADEL
IKLSK
//
