ID A0A0D1A6N6_9LACO Unreviewed; 867 AA.
AC A0A0D1A6N6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Aldehyde-alcohol dehydrogenase {ECO:0000256|PIRNR:PIRNR000111};
GN ORFNames=WDC_1006 {ECO:0000313|EMBL:KIS03372.1};
OS Paucilactobacillus wasatchensis.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Paucilactobacillus.
OX NCBI_TaxID=1335616 {ECO:0000313|EMBL:KIS03372.1, ECO:0000313|Proteomes:UP000032279};
RN [1] {ECO:0000313|EMBL:KIS03372.1, ECO:0000313|Proteomes:UP000032279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WDC04 {ECO:0000313|EMBL:KIS03372.1,
RC ECO:0000313|Proteomes:UP000032279};
RA Oberg C.J., Culumber M., McMahon D.J., Broadbent J.R., Oberg T.S.,
RA Ortaki F.;
RT "Lactobacillus wasatchii sp. WDC04, a late gas producing bacteria isolated
RT from aged chedder cheese.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC Evidence={ECO:0000256|ARBA:ARBA00001954};
CC -!- SIMILARITY: In the C-terminal section; belongs to the iron-containing
CC alcohol dehydrogenase family. {ECO:0000256|ARBA:ARBA00035645,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the aldehyde
CC dehydrogenase family. {ECO:0000256|ARBA:ARBA00035641,
CC ECO:0000256|PIRNR:PIRNR000111}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KIS03372.1}.
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DR EMBL; AWTT01000021; KIS03372.1; -; Genomic_DNA.
DR RefSeq; WP_044010756.1; NZ_AWTT01000021.1.
DR AlphaFoldDB; A0A0D1A6N6; -.
DR STRING; 1335616.WDC_1006; -.
DR PATRIC; fig|1335616.4.peg.1011; -.
DR OrthoDB; 9815791at2; -.
DR Proteomes; UP000032279; Unassembled WGS sequence.
DR GO; GO:0008774; F:acetaldehyde dehydrogenase (acetylating) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004022; F:alcohol dehydrogenase (NAD+) activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006066; P:alcohol metabolic process; IEA:InterPro.
DR GO; GO:0015976; P:carbon utilization; IEA:InterPro.
DR CDD; cd08178; AAD_C; 1.
DR CDD; cd07122; ALDH_F20_ACDH; 1.
DR Gene3D; 3.40.50.1970; -; 1.
DR Gene3D; 1.20.1090.10; Dehydroquinate synthase-like - alpha domain; 1.
DR InterPro; IPR034789; AAD_C.
DR InterPro; IPR001670; ADH_Fe/GldA.
DR InterPro; IPR018211; ADH_Fe_CS.
DR InterPro; IPR039697; Alcohol_dehydrogenase_Fe.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR012079; Bifunc_Ald-ADH.
DR PANTHER; PTHR11496; ALCOHOL DEHYDROGENASE; 1.
DR PANTHER; PTHR11496:SF83; HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR Pfam; PF00465; Fe-ADH; 1.
DR PIRSF; PIRSF000111; ALDH_ADH; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR SUPFAM; SSF56796; Dehydroquinate synthase-like; 1.
DR PROSITE; PS00913; ADH_IRON_1; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|PIRNR:PIRNR000111};
KW Reference proteome {ECO:0000313|Proteomes:UP000032279}.
FT DOMAIN 14..406
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
FT DOMAIN 463..850
FT /note="Alcohol dehydrogenase iron-type/glycerol
FT dehydrogenase GldA"
FT /evidence="ECO:0000259|Pfam:PF00465"
SQ SEQUENCE 867 AA; 94646 MW; 05736B1AE7E8938F CRC64;
MIKEPQTKKV DVNQSIEKLV AAGHVALDKL DQFDQETIDH IVHQMAMAAL DKHMLLAKLA
YEETGRGVIE DKAVKNIYAS EYIWHSIAHD KTVGVIKDDK ERQLITVAEP LGVIAGITPV
TNPTSTTIFK SLIAVKTRNP IIFAFHPQAQ SSSAAAAKIL LDAAVEAGAP ENIIQWIEQP
SLEATTALIN NDGVASVLAT GGPGMVKAAY STGKPALGVG PGNGPVYIEK TARIKRAVND
ILLSKTFDNG MVCASENSAV VDDAIYDEVK AEFKAHKAYF VAKKDQKALS DAMFDEKRGG
VKGPIPGMSA VKIAELAGIK VPDDTKILVA EITGVGPQQP LSREKLAPVL SMYRAKTQAE
AFQTCDDLLH FGGLGHTAVI QSEDDDLILK FGLKMKASRV IVNTPSALGG IGNMYNEMIP
SLTLGTGSWG KNSISHNVSS FDLLNVKTIA KRRNNMQWVK LPRVYFEKTS VRYLEDMPDV
KKVMLITGPS MVKYGYADIV VNELKRRPNG NQVQYEIFSD IEPDPSTDTV ERGVQQIREF
EPDTIIALGG GSPLDAAKNM WLFYEHPEAS FFGAKQKFLD IRKRTYRFGT PNKAKFVAIP
TTSGTGSEVT PFAVITDSKT HVKYPLADYA LTPDVAIVDS QFIETVPKKT IAYSGLDVLT
HATESFVSAL ASDYTRPWSL QAAKLVFDNL TASYNGDAHA REEMHNASTL AGMAFGNAFL
GINHSVAHKL GGEFGLAHGL CIAITYPHVV RYNATEPRKL QAWPKYEYFR ANKDYADLAR
YVGVQGTTDE ELVEGLVQKF IDLAHSVGVE LSLKANGVKK AEFDKAVDNM AELAYEDQCT
TANPKEPLIA DLKQIMIDDF EGTNVEK
//
