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Database: UniProt
Entry: A0A0D1A9I9_9LACO
LinkDB: A0A0D1A9I9_9LACO
Original site: A0A0D1A9I9_9LACO 
ID   A0A0D1A9I9_9LACO        Unreviewed;       438 AA.
AC   A0A0D1A9I9;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-SEP-2017, entry version 22.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KIS03416.1};
GN   ORFNames=WDC_0995 {ECO:0000313|EMBL:KIS03416.1};
OS   Lactobacillus wasatchensis.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=1335616 {ECO:0000313|EMBL:KIS03416.1, ECO:0000313|Proteomes:UP000032279};
RN   [1] {ECO:0000313|EMBL:KIS03416.1, ECO:0000313|Proteomes:UP000032279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WDC04 {ECO:0000313|EMBL:KIS03416.1,
RC   ECO:0000313|Proteomes:UP000032279};
RA   Oberg C.J., Culumber M., McMahon D.J., Broadbent J.R., Oberg T.S.,
RA   Ortaki F.;
RT   "Lactobacillus wasatchii sp. WDC04, a late gas producing bacteria
RT   isolated from aged chedder cheese.";
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KIS03416.1}.
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DR   EMBL; AWTT01000020; KIS03416.1; -; Genomic_DNA.
DR   RefSeq; WP_044010742.1; NZ_AWTT01000020.1.
DR   EnsemblBacteria; KIS03416; KIS03416; WDC_0995.
DR   PATRIC; fig|1335616.4.peg.998; -.
DR   Proteomes; UP000032279; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000032279};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032279}.
FT   DOMAIN      135    266       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      346    415       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     143    150       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   438 AA;  49437 MW;  EEC61773B762F7DA CRC64;
     MTDLKTLWDT IKESFKNDVS SVTYENLIEP AKAISLSNNQ LTIELPTPFH KDYWSESLTD
     KFRLYAFEAT STKIEPRYII EAEEQTAPVM TASKPSFKVN TALNPRYTFD TFVIGKGNQM
     AHAAALVVSE EPGKMYNPLF FYGGVGLGKT HLMHAIGNKM SGVNSQTRVK YVTSEAFTND
     FINAIQTGTQ EQFRQEYRNL DLLLVDDIQF FADKEGTQEE FFHTFNALYE ENKQIVLTSD
     RLPNEIPKLQ DRLVSRFKWG LSVDITPPDL ETRIAILRSK AKADQIDIPN DTLTYIAGQI
     DSNVRELEGA LSRVQAYSHL NNATINTSLA SDALKGLKLS GTSALTIPLI QEKVAGYYHI
     SQTDLKGKKR VKQIVMPRQI AMYLARELTD NSLPKIGTEF GGKDHTTVLH SIDKIEELLQ
     SDHNLQEDVQ NLKMELKP
//
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