ID A0A0D1BVI7_USTMA Unreviewed; 1036 AA.
AC A0A0D1BVI7;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=HRDC domain-containing protein {ECO:0000259|PROSITE:PS50967};
GN ORFNames=UMAG_11213 {ECO:0000313|EMBL:KIS66042.1};
OS Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Ustilago.
OX NCBI_TaxID=237631 {ECO:0000313|EMBL:KIS66042.1, ECO:0000313|Proteomes:UP000000561};
RN [1] {ECO:0000313|EMBL:KIS66042.1, ECO:0000313|Proteomes:UP000000561}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=521 / FGSC 9021 {ECO:0000313|Proteomes:UP000000561};
RX PubMed=17080091; DOI=10.1038/nature05248;
RA Kamper J., Kahmann R., Bolker M., Ma L.J., Brefort T., Saville B.J.,
RA Banuett F., Kronstad J.W., Gold S.E., Muller O., Perlin M.H., Wosten H.A.,
RA de Vries R., Ruiz-Herrera J., Reynaga-Pena C.G., Snetselaar K., McCann M.,
RA Perez-Martin J., Feldbrugge M., Basse C.W., Steinberg G., Ibeas J.I.,
RA Holloman W., Guzman P., Farman M., Stajich J.E., Sentandreu R.,
RA Gonzalez-Prieto J.M., Kennell J.C., Molina L., Schirawski J.,
RA Mendoza-Mendoza A., Greilinger D., Munch K., Rossel N., Scherer M.,
RA Vranes M., Ladendorf O., Vincon V., Fuchs U., Sandrock B., Meng S.,
RA Ho E.C., Cahill M.J., Boyce K.J., Klose J., Klosterman S.J., Deelstra H.J.,
RA Ortiz-Castellanos L., Li W., Sanchez-Alonso P., Schreier P.H.,
RA Hauser-Hahn I., Vaupel M., Koopmann E., Friedrich G., Voss H., Schluter T.,
RA Margolis J., Platt D., Swimmer C., Gnirke A., Chen F., Vysotskaia V.,
RA Mannhaupt G., Guldener U., Munsterkotter M., Haase D., Oesterheld M.,
RA Mewes H.W., Mauceli E.W., DeCaprio D., Wade C.M., Butler J., Young S.,
RA Jaffe D.B., Calvo S., Nusbaum C., Galagan J., Birren B.W.;
RT "Insights from the genome of the biotrophic fungal plant pathogen Ustilago
RT maydis.";
RL Nature 444:97-101(2006).
RN [2] {ECO:0000313|Proteomes:UP000000561}
RP GENOME REANNOTATION.
RC STRAIN=521 / FGSC 9021 {ECO:0000313|Proteomes:UP000000561};
RA Gueldener U., Muensterkoetter M., Walter M.C., Mannhaupt G., Kahmann R.;
RL Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the exosome component 10/RRP6 family.
CC {ECO:0000256|ARBA:ARBA00043957}.
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DR EMBL; CM003160; KIS66042.1; -; Genomic_DNA.
DR RefSeq; XP_011392493.1; XM_011394191.1.
DR AlphaFoldDB; A0A0D1BVI7; -.
DR STRING; 237631.A0A0D1BVI7; -.
DR EnsemblFungi; KIS66042; KIS66042; UMAG_11213.
DR GeneID; 23567123; -.
DR KEGG; uma:UMAG_11213; -.
DR VEuPathDB; FungiDB:UMAG_11213; -.
DR eggNOG; KOG2206; Eukaryota.
DR InParanoid; A0A0D1BVI7; -.
DR OrthoDB; 2880475at2759; -.
DR Proteomes; UP000000561; Chromosome 21.
DR GO; GO:0000176; C:nuclear exosome (RNase complex); IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0000175; F:3'-5'-RNA exonuclease activity; IBA:GO_Central.
DR GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR GO; GO:0000467; P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0071044; P:histone mRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071040; P:nuclear polyadenylation-dependent antisense transcript catabolic process; IBA:GO_Central.
DR GO; GO:0071039; P:nuclear polyadenylation-dependent CUT catabolic process; IBA:GO_Central.
DR GO; GO:0071035; P:nuclear polyadenylation-dependent rRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071036; P:nuclear polyadenylation-dependent snoRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071037; P:nuclear polyadenylation-dependent snRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071038; P:nuclear polyadenylation-dependent tRNA catabolic process; IBA:GO_Central.
DR GO; GO:0071051; P:polyadenylation-dependent snoRNA 3'-end processing; IBA:GO_Central.
DR CDD; cd06147; Rrp6p_like_exo; 1.
DR Gene3D; 1.10.150.80; HRDC domain; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR InterPro; IPR012588; Exosome-assoc_fac_Rrp6_N.
DR InterPro; IPR010997; HRDC-like_sf.
DR InterPro; IPR002121; HRDC_dom.
DR InterPro; IPR044876; HRDC_dom_sf.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR045092; Rrp6-like.
DR InterPro; IPR049559; Rrp6p-like_exo.
DR PANTHER; PTHR12124:SF47; EXOSOME COMPONENT 10; 1.
DR PANTHER; PTHR12124; POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED; 1.
DR Pfam; PF01612; DNA_pol_A_exo1; 1.
DR Pfam; PF00570; HRDC; 1.
DR Pfam; PF08066; PMC2NT; 1.
DR SMART; SM00474; 35EXOc; 1.
DR SMART; SM00341; HRDC; 1.
DR SUPFAM; SSF47819; HRDC-like; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50967; HRDC; 1.
PE 3: Inferred from homology;
KW Exosome {ECO:0000256|ARBA:ARBA00022835};
KW Reference proteome {ECO:0000313|Proteomes:UP000000561};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552}.
FT DOMAIN 582..666
FT /note="HRDC"
FT /evidence="ECO:0000259|PROSITE:PS50967"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..928
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..970
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 973..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1030
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1036 AA; 113194 MW; A5A995B31D68B525 CRC64;
MVATSKRSAA STQSCTTAPR LASSCSSASV ASTPEPAAST LPDPKTHLSS YLEKLQSALQ
PLTRNAAAIP NHGDLAFHRS MDRKLAKKLD SESDRVLHSI SQLVGWIASD PRAPTIPLAN
RAASSSNSSS HSTNSRNPSV DVNLHLADVT TNQSFASNLG ELVDHLLESA DTCLDEYTGK
LAPRKLGSAA EENAASGNAA GEIGTSSRLQ AMTAVQNGKA LPKTGNLPSW VLNAPISPPQ
RHFTRKPDNS ADSIWLPHLK YGKPNAKVAL GHVHPPRFNA DGTPIPRGPR RGMYCAEGDP
LDNPYHHEIM HADPPSHALS KPDPVAKDNP PPALNEKDPW LSTDACPFQW VSTKQQIEQL
RDHLDEPRVN EIAIDLEHHS YRTYQGIVCL MQLSTRWGDW IIDTLSDDVR QHAELLNSSF
TNPDKVKVLH GANHDVLWLQ RDLGLYLVNL FDTYHATNVL MFPSHGLNYL MARYCNFDAD
KRYQLADWRI RPLPKEMLYY ARSDTHTLLF IYDNLRHELM EAGGIDAIRQ VFIRSKQVAT
ATYAKEQWDT DGETREGWRT VWRKWGGEAA LGTEHRKEVS QMKKEERLVR ALHRWRDTVA
REEDESPRYI LGANNLMMLA ARAPTTKQGV LACIPPNATG LKKRIDELAS LIMAEVADWQ
KDQQARRDES KQRLSAALLN SDNKHGELDQ EMDAGEAIRR DAVVKPVTNQ QDTTKTSNVG
TLPSISAWSR VTGADEQVDV SVWSDATTTG GSASDRRAVA SRFGGAVRSL ASNLFGRSNA
SATRAAAAVS HSNLSSSSSK LFGTSAPLIR DRDTCSTAQV DSVKAGFIGQ VEVFLGNPVS
SVPERGDIMM QPDSVAFVPS GDRATCTARV NAFCSTEASQ RAPTPAEAAD DDDDDGSSEK
DDYIIVSTTA NSKKSKNKPN SSACKPESTA PSKKELKKKR KAEEAAGALA TDSTTSAHTK
KRKGKFQGEF DFSSTRDALQ AAASETKQHG ASPSNKQSGS SSKRDGSKPR TKDHDAAVFR
QPRDRARRKT GMGSTM
//
