ID   A0A0D1VTA6_9EURO        Unreviewed;       657 AA.
AC   A0A0D1VTA6;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=tRNA pseudouridine(38-40) synthase {ECO:0000313|EMBL:KIV79355.1};
GN   ORFNames=PV11_06921 {ECO:0000313|EMBL:KIV79355.1};
OS   Exophiala sideris.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX   NCBI_TaxID=1016849 {ECO:0000313|EMBL:KIV79355.1, ECO:0000313|Proteomes:UP000053599};
RN   [1] {ECO:0000313|EMBL:KIV79355.1, ECO:0000313|Proteomes:UP000053599}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 121828 {ECO:0000313|EMBL:KIV79355.1,
RC   ECO:0000313|Proteomes:UP000053599};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Exophiala sideris CBS121828.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the tRNA pseudouridine synthase TruA family.
CC       {ECO:0000256|ARBA:ARBA00009375}.
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DR   EMBL; KN846953; KIV79355.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D1VTA6; -.
DR   STRING; 1016849.A0A0D1VTA6; -.
DR   HOGENOM; CLU_014673_2_3_1; -.
DR   OrthoDB; 167554at2759; -.
DR   Proteomes; UP000053599; Unassembled WGS sequence.
DR   GO; GO:0009982; F:pseudouridine synthase activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0001522; P:pseudouridine synthesis; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.660; Pseudouridine synthase I, catalytic domain, C-terminal subdomain; 1.
DR   Gene3D; 3.30.70.580; Pseudouridine synthase I, catalytic domain, N-terminal subdomain; 1.
DR   HAMAP; MF_00171; TruA; 1.
DR   InterPro; IPR020103; PsdUridine_synth_cat_dom_sf.
DR   InterPro; IPR001406; PsdUridine_synth_TruA.
DR   InterPro; IPR020097; PsdUridine_synth_TruA_a/b_dom.
DR   InterPro; IPR020095; PsdUridine_synth_TruA_C.
DR   InterPro; IPR020094; TruA/RsuA/RluB/E/F_N.
DR   PANTHER; PTHR11142; PSEUDOURIDYLATE SYNTHASE; 1.
DR   PANTHER; PTHR11142:SF5; TRNA PSEUDOURIDINE(38_39) SYNTHASE; 1.
DR   Pfam; PF01416; PseudoU_synth_1; 1.
DR   SUPFAM; SSF55120; Pseudouridine synthase; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053599};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT   DOMAIN          373..516
FT                   /note="Pseudouridine synthase I TruA alpha/beta"
FT                   /evidence="ECO:0000259|Pfam:PF01416"
FT   REGION          9..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          38..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          89..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          588..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..57
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   657 AA;  73450 MW;  513533488B1B8943 CRC64;
     MPLCRAFRRA SSTSRLVPHH SKSSKVRSPL QHRLKSPAYP YSAMSNNDES ATQHVTEDYS
     TYSTTDLLNR INGLEAKLRE QTAQIAVLTS KSTSTHTPSP APSRPRTPSP KRQARPFDPS
     LYSTRHIALK FAYLGGRYNG FEHANGNVTP MPTIEEVLWK ALRKSRLISP EIPNGADDTM
     EVLWSAQARM QRYTKDDMPG KVRLDLNWEG CQYSKCGRTD RGVSAFGQVV GVRVRSNRPL
     PKQETQNSLK DHVSVADMDK DVNGDEEDDM PAIEVDDLDA DTYAKPWDSV KDELQYVSIL
     NAILPPDIRV LAWCPDPPPT FDARFSCRER RYKYFFTNPA FCPVPGPPGM NFAGGKPRGM
     REGWLDIEKM REAAKKLEGL HDFRHLCKID ASKQMPSCER RITFADVVEF GEVGTAFSQH
     EGLTQFAGMS LTQTLLGDTT QLSSSAGPKV YTFCVHGNAF LWHQVRCMVA VLFLVGQGLE
     QPSIIDEMLD INTTPRRPTY EMADDAPLVL WDCIFPADDS NIVDSLKWLY AGDEANVRSS
     LTTKGDGKFG PGGVVEELWS IWREAKVQEI LAGSLLDLAV HQGDGSALKK GVQRDTPRGP
     SLSQKVFQGG NDAKSHGRFI AMMQRPRMDS LEAVNAKWAK NRKARLDAEE YEETNTD
//