ID A0A0D1X7N7_9EURO Unreviewed; 1763 AA.
AC A0A0D1X7N7;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=chitin synthase {ECO:0000256|ARBA:ARBA00012543};
DE EC=2.4.1.16 {ECO:0000256|ARBA:ARBA00012543};
GN ORFNames=PV11_05845 {ECO:0000313|EMBL:KIV83856.1};
OS Exophiala sideris.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=1016849 {ECO:0000313|EMBL:KIV83856.1, ECO:0000313|Proteomes:UP000053599};
RN [1] {ECO:0000313|EMBL:KIV83856.1, ECO:0000313|Proteomes:UP000053599}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 121828 {ECO:0000313|EMBL:KIV83856.1,
RC ECO:0000313|Proteomes:UP000053599};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala sideris CBS121828.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Polymerizes chitin, a structural polymer of the cell wall and
CC septum, by transferring the sugar moiety of UDP-GlcNAc to the non-
CC reducing end of the growing chitin polymer.
CC {ECO:0000256|ARBA:ARBA00024009}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-
CC D-glucosamine = [(1->4)-N-acetyl-beta-D-glucosaminyl](n+1) + H(+) +
CC UDP; Xref=Rhea:RHEA:16637, Rhea:RHEA-COMP:9593, Rhea:RHEA-COMP:9595,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17029, ChEBI:CHEBI:57705,
CC ChEBI:CHEBI:58223; EC=2.4.1.16;
CC Evidence={ECO:0000256|ARBA:ARBA00000319};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KN846952; KIV83856.1; -; Genomic_DNA.
DR STRING; 1016849.A0A0D1X7N7; -.
DR HOGENOM; CLU_000192_0_0_1; -.
DR OrthoDB; 1331060at2759; -.
DR Proteomes; UP000053599; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004100; F:chitin synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR GO; GO:0048315; P:conidium formation; IEA:UniProt.
DR CDD; cd04190; Chitin_synth_C; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR004835; Chitin_synth.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR014876; DEK_C.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22914; CHITIN SYNTHASE; 1.
DR PANTHER; PTHR22914:SF13; CHITIN SYNTHASE; 1.
DR Pfam; PF03142; Chitin_synth_2; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF08766; DEK_C; 1.
DR SMART; SM01117; Cyt-b5; 2.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 2.
DR SUPFAM; SSF109715; DEK C-terminal domain; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51998; DEK_C; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053599};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 724..744
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..778
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1021..1040
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1412..1435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1447..1466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1473..1496
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1704..1761
FT /note="DEK-C"
FT /evidence="ECO:0000259|PROSITE:PS51998"
SQ SEQUENCE 1763 AA; 195548 MW; E38BD9630F6B41C8 CRC64;
MANRYSTYSN KSSQVGAARS AAQQSTQVST TTLLNALHTI YASGQTYELD SSTSIAVNTW
LSAANPDAHG RTGGTVDADL ASRAWDHARR RAEDACVVLG SLHPSTPSLL QPFLQVIPVP
TPNLAYTALS ALRPFLSCVT PANPTTYRHS SLSAKYTITL DGTITGFNLA LSGSGIDVQK
GLLKVPAESG YRAFDVFYYL LTSASTPAER EFLDLKPASR YTLLSGSGTH NPPSYIPTAD
DTAAAEDFRS ALKSIGIKGA SFRGLLSCLA GLLKLGETTG FLVDSDTLED MCEDVGALIG
LEPDVLVNKC NSDDREVLIA GMYEALVDWV ISKANDAIAA ELRAGALTPD SSSGDEVSVT
VVEIPGEALG KAVALRNVFD DTFGINAEMK EDGLEVAAAG SSVLKEMHLA VSQAEADLGI
SGGPLSRERE HDRDRREGIL QKIGAEAESG GFLHTLLYPV NGEALNFGKR GRFDLGITLA
SSRAWYQLSI HPTDDSPSTL SGLASPTSAW SAGAVSRQLR AWRLPEWANH RNRHLDFTAD
FDVEEFVTRY SRLGCKDGMD GIESFLLERG WTNREVVIGR ERVWMRESAW WEAETILDLK
PMPPSYSDEA AIGQHTNPFL SSYSVNAPDN ASAFFPPMGD GMSVLDSKDD LLDPVAANRA
KSLAPTMART VQTIGGDYGL GPKGDPNKDQ YWDSDLGRFT GELDPEFGDP RNVESKKTSA
GRQAWASLVW ALTWFIPSIF LRYIGRMKRP DVRMAWREKI VLVMLITLLN AFIVFYIVEF
GRLLCPNFDK AWNDKEVGYH QGTNDYYVSI RGGVYDMTKF YKTQHSDTST QTDSTNMLPF
AGLNLDAYFP VPLSVACPGL NVNTTVELQN NNTDAVVYST AVHYSGPQFQ TDSSSALYNI
NWYSDTFLPK IKQYYKGDLV VTRGNVQSQA NDDDRIWVII DKKIYDLTNY FYTLTLMNNY
PTYKFFPDEV SDLISGNPGS DITKQWGTTA AYQNSLNCMN NAFYVGKVDF RDTAKCQVNN
YILLAFTIII CAVILVKFLA ALQLGSKRRP AAQDRFVICQ VPAYTEGEDH LRKSLDSLTA
LQYDNKRKLI CVICDGMIVG GGNDRPTPKI VLDILGVDPK IDPPALPFRS VGNASEQLNY
GKVYSGLYEC EGNVVPYIVV VKVGKESEQT KSKPGNRGKR DSQILLMQFL NRVHHRSPMS
PLELEMFHQI NNIIGVDPEL YEYLLMVDAD TMVKEDSLNR LVAACANDAK IAGICGETSL
ENEERSWWTM IQVYEYYISH HLAKSFESLF GSVTCLPGCF CMYRLRTADK GRPLIISDKV
INEYSDCDVD TLHKKNLLSL GEDRYLTTLM TKHFPAMSYK FIPDAYAQTA APETWSVLLS
QRRRWINSTI HNLAELVWLK DLCGFCCFSM RFVVFIDLFG TLILPATCVY LGYLIYRVAS
GTGQFPLISI ILLAAVYGLQ AIIFIIKRQW QHVGWMLIYI IAYPIYSFVL PIYSFWNQDN
FSWGNTRIVI GEKGDKKVVA IQDEGFDPRS IPLQRWDDYA AFNNLPGRRG NPGSYQEKGF
EAGYTDDPAM MEMDDIHSTY SSVKPASTIL TGFPHMQQNP FMAPPRSPAP MGMNHRASTM
TGLTQFKDQP VTVHGRNMSL MSLGSAARLK SPSPNHYYQD NQRSPYQSGY GGMQQSMSRP
SLLGMANSRP ASTIMDFRTV PSAGPGDQEI VESIRLVLSE VDLETVTKKQ VRALVEQRLQ
CEVPVGERRQ FLDKAIDNEL ANM
//
