ID A0A0D1XZC7_9PEZI Unreviewed; 2454 AA.
AC A0A0D1XZC7;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=PV09_01097 {ECO:0000313|EMBL:KIW08166.1};
OS Verruconis gallopava.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Venturiales; Sympoventuriaceae; Verruconis.
OX NCBI_TaxID=253628 {ECO:0000313|EMBL:KIW08166.1, ECO:0000313|Proteomes:UP000053259};
RN [1] {ECO:0000313|EMBL:KIW08166.1, ECO:0000313|Proteomes:UP000053259}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 43764 {ECO:0000313|EMBL:KIW08166.1,
RC ECO:0000313|Proteomes:UP000053259};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Ochroconis gallopava CBS43764.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR EMBL; KN847531; KIW08166.1; -; Genomic_DNA.
DR RefSeq; XP_016218035.1; XM_016353940.1.
DR STRING; 253628.A0A0D1XZC7; -.
DR GeneID; 27309070; -.
DR VEuPathDB; FungiDB:PV09_01097; -.
DR HOGENOM; CLU_000178_4_1_1; -.
DR InParanoid; A0A0D1XZC7; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000053259; Unassembled WGS sequence.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF69; SERINE/THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053259}.
FT DOMAIN 1432..2006
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2117..2427
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2422..2454
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 36..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2454 AA; 275354 MW; 4F5D681DE0D9AA35 CRC64;
MKTRLSASTH YLTFHPSGAF YEWDFICSNE QRMASRSRNL RSTQNGQSGS MQSTNGNYLP
PSTIAAQIVH NRSTVARSEP ENKALFGKLL QEYLRDPIVE DSSIETHAQL VQVVAEAGLD
VLLSDDPFAL DSLVQQARDS LLVIRLTIIR KPDVLFYKGE GEEERPPLLL WLLAKILNLS
GRRTLSLIQM DLRELLQSIF AVLSTKNRTL SCSFDFKMLL TDVVEDLLNT LERRQYEDDS
DKPPIRAVVP SPNAMTRLWT PAGSLLVLPT GYQAVIRDPI QAQVLIMDIV AVLSHCSTGH
SSDSFMSNSD ETLQFDCCHR ILDFCATAPS TTNEDHDRVF DSVASFLLSK IQKRCPRRKI
HPAVDLLVHL LDHLRPQRYP NFSKTVLEAI EQLLQRCSSQ PNHAGLLQRN LLPVLQHIAH
DFSQDVDDEF SAHVAGIIAR LTKTTAYLDG SSPPTKKLRL STIRSDIYED YRKGIAKEIN
NLLFDIHETD FPILDENALQ RLREFDDAKR ATIIGCLGRL ACASAGSSAL ELDGSASSRC
KICDSMAAPA ERAGVDAKIT KRAEESSIHL LSFMALCIED SSLCRSKIFR VAVANSIRQI
SNHLDDSECS VLSWKGIGPW LMRSLQSSVR ELRIASAEAL VAYSRESLSE PVRSRNRLDT
LDFFKCLADK NNLTDQETLT FAWGLIGRTC GDAELNLALI QLVDYLGHSH SLVSGAAYQE
LLQLADSREC SPSELLRPYW SSLAMHVVKD IYACPQKVQQ LSELLGITVN ELLIQTQADT
VPFLVLTRKK DVLLRIAQAR GPSINVQDLW LQPSKNLAAV LALLLIQPSE DPEQAAIALL
KDASPAFAEE DLSALVKAES IPIACEILKH AADLPDVRKP QAHQGMRLLA CINEKKSTSR
SSSKSGKHLS AFLDAHILGI MSHFTDIIDA PLQRQPMVEK HRALRAVQQL IILGDVQVSI
VIPQIRATLQ SASKIPALVD QAFLTWAALV AAAGEDEIEL LIDQTFAMIA HHWNGYTSST
QRRAYDTIAG LLKNHNAMVR DRIQMLPSLA GIEMLSKFES EIARLKATLD PILHFEAYAQ
RCSDENSIIV LRALVDLGPF LEQHQKIIHE SAVSQQPSPV IARLSRALLD AVVRFKESDS
TIPELAAKCL GAIGSIDPNK VDHMRERHEL LMLSNFGKAS EVVDFVAVML ERVIVDAFHS
APTGRAQTYL AYTMQELLKF CDFRTAVYRP RSSQSGPKFQ RWMQIPESVR STLTPFFNTK
YVLVHPSLPG DHDSFPILKP GMVHGTWLRT FVFSLLHKGT TENAQMVFPV LSRIIWGHDI
SIPTFLLPFV VLNVVVGGND DDVRAINAEF LRVLSIDIDA IDASSAEEVK HCSENIFQVL
DYLSRWLQVK KKLLGEFGGG RSVQVPNDYD EVTETSHISS VEAVLSSIPA DVISQRAVHC
RSFARALFHW EQHIRQLADK AALKREDIEL DQQLRHLQHI YAQIDEPDAV EGMSTRLQIL
DPEQQILEHK RAGRWTTAQT WFELSLIERP NDRGLQMELL SCLRSSNRYG SLLDTAQRLT
VEHPDSIAQV LPFAVEAAWT TGKWESLERF LSSDAAKDVR DFNTEVGRLF LCLLKKDVSG
FERLLSTLRA SIASAFSLST TSSLGTAHTH TIKLHALYEL EQIGALKDRV ITPDQLVDRL
SKRLDILGAY TADKQYLLGI RRAAMQLSAM GFSKQQIGAN WLTSARLSRK AGLRDAAYDA
VLHSTNLHDG AAMIEHSRLL WQDGHHRKAI QNLQSAIESN VFQSYTTSMI DDQSLTTDEG
HSNKNQNFLV AKTQLLLAKW MDRSGHSKSE ELRAHFLQAC KSFSRWEKGH YYMGKHYLKI
LESEKALPRA KQTDIYLTGD VQKLVIENFM RSMVFGAKYY YETVPKMLTL WLDLAADIYN
AERNPRTLDQ QYHSLRVRKL EVVHKQVKKY VDRLPSYVFY TALPQVTSRI NHPHAKANEI
LLHLIHKVIS IHPQQSLWSI LAVAKSRASD KSSKAGLVLQ QLRRTRSETS AVDVKLLIAH
GEKLTNALLA ACEVTVESRS SRASLSRDLG FNHKLAPCQL VVPVEKALSA NLPTGIGGPC
VRNHKAFPRN PITISSFLDD VLVLSSLQRP KKLTMRGSDG VNYGLLCKPK DDLRKDQRLM
EFTTMIDRGL KRDVESSKRR LYIHTYAVTP LNEECGAIEW VDGLKPMRDI ILANYKTKGL
RPDYGELRQL LDRACADPEK GSWKIFPEQI VPKFPAVLHE WFIDTFPEPD SWFTARLRYT
RSCAVMSMVG NALGLGDRHG ENILLEEGNG GCFHVDFNCL FDKGLTFEKP ELVPFRLTHN
MIDAFGVYGY EGPFRVASEL TLKILKQYED TLMTIMETFV YDPTTDFISK PKKRVVGVPE
TPAEVLESVK AKINRLLPGE TVPLSVDGYA DALIRMATDP KRLAGMYIGW CAFF
//