ID A0A0D1ZYW0_9EURO Unreviewed; 328 AA.
AC A0A0D1ZYW0;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=NADP-dependent oxidoreductase domain-containing protein {ECO:0000259|Pfam:PF00248};
GN ORFNames=PV08_05047 {ECO:0000313|EMBL:KIW17852.1};
OS Exophiala spinifera.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=91928 {ECO:0000313|EMBL:KIW17852.1, ECO:0000313|Proteomes:UP000053328};
RN [1] {ECO:0000313|EMBL:KIW17852.1, ECO:0000313|Proteomes:UP000053328}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 89968 {ECO:0000313|EMBL:KIW17852.1,
RC ECO:0000313|Proteomes:UP000053328};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala spinifera CBS89968.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN847494; KIW17852.1; -; Genomic_DNA.
DR RefSeq; XP_016238068.1; XM_016379391.1.
DR AlphaFoldDB; A0A0D1ZYW0; -.
DR STRING; 91928.A0A0D1ZYW0; -.
DR GeneID; 27332130; -.
DR VEuPathDB; FungiDB:PV08_05047; -.
DR HOGENOM; CLU_023205_0_0_1; -.
DR OrthoDB; 5305445at2759; -.
DR Proteomes; UP000053328; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR11732; ALDO/KETO REDUCTASE; 1.
DR PANTHER; PTHR11732:SF389; D-XYLOSE REDUCTASES (EUROFUNG); 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053328}.
FT DOMAIN 18..221
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 51
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 114
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 81
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 328 AA; 36292 MW; 642D55983958689B CRC64;
MSRGTKVNLN TGAAIPTLGY GTWQSAPGEV SVGVYEALKA GYRHLDLAKV YGNQPEVAQG
LKKALAEIPG LKREDIFITS KLWNNSHRPE YVEEALDQTL KELDLDYLDL YLIHWPVAFE
RRSANELFPL TAKDSDETVL DDGVSIVDTW KAVVKLPKSK VRAVGVSNFT PEHLQAVIDA
TGVVPAVNQI ERHPLLQQND TLIKYAKEKN IHITAYSAFG NNTIGVPLLI EHPVVKDVAD
KIGATPAQVL LAWAQVGGHS VIPKSVTPSR IKSNFQEVTL GEDDVAAVNK IGETPRRYNI
PMTYHPRWNV NIWNEEPEQN ARRGVILG
//
