ID   A0A0D2ABH5_9PEZI        Unreviewed;      1094 AA.
AC   A0A0D2ABH5;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 38.
DE   RecName: Full=HECT domain-containing protein {ECO:0000259|PROSITE:PS50237};
GN   ORFNames=PV09_04484 {ECO:0000313|EMBL:KIW04168.1};
OS   Verruconis gallopava.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Venturiales; Sympoventuriaceae; Verruconis.
OX   NCBI_TaxID=253628 {ECO:0000313|EMBL:KIW04168.1, ECO:0000313|Proteomes:UP000053259};
RN   [1] {ECO:0000313|EMBL:KIW04168.1, ECO:0000313|Proteomes:UP000053259}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 43764 {ECO:0000313|EMBL:KIW04168.1,
RC   ECO:0000313|Proteomes:UP000053259};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Ochroconis gallopava CBS43764.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN847541; KIW04168.1; -; Genomic_DNA.
DR   RefSeq; XP_016214037.1; XM_016357835.1.
DR   AlphaFoldDB; A0A0D2ABH5; -.
DR   STRING; 253628.A0A0D2ABH5; -.
DR   GeneID; 27312457; -.
DR   VEuPathDB; FungiDB:PV09_04484; -.
DR   HOGENOM; CLU_001858_0_0_1; -.
DR   InParanoid; A0A0D2ABH5; -.
DR   OrthoDB; 1820836at2759; -.
DR   Proteomes; UP000053259; Unassembled WGS sequence.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   InterPro; IPR032353; AZUL.
DR   InterPro; IPR044611; E3A/B/C-like.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR   Pfam; PF16558; AZUL; 1.
DR   Pfam; PF00632; HECT; 1.
DR   SMART; SM00119; HECTc; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   PROSITE; PS50237; HECT; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053259};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104}.
FT   DOMAIN          726..1094
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          139..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        164..178
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1061
FT                   /note="Glycyl thioester intermediate"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ   SEQUENCE   1094 AA;  125116 MW;  2E90DE4C0CC34D45 CRC64;
     MAAMQESPLD LKLWHKVFGA LGVIPRSNVL VERKQKSRLV AFHLLLQCFA LQIRYGCENK
     DCKTLGCFSC RRRNTSEPVR RPTLLAARNQ AFVLASTDDP LSYLCPNPLR TDIDGDERVD
     TNLVRAYVLS LQNGDDAMRA SQAAIQGQKR GDDPTSSPSR NGQCDDSSED KHAKTNTTQT
     KVDRASLVQN LFNTNKMAYW FDSQCNTRDN SKSKDLDVMV FTELSRELAM AIATALTRIS
     GSYRDRFASI TDLVVRSIRY NFSSPSRLLE QWSSPGPQIP IASLSRMPFK EVLDTDGNVI
     NSIVAMDKPH EHLRHWTALP AAFEEMLTAM WNALDALLVP PPRIAGSKNN TLGTAYVSDD
     QAARMIFIAI LLLIVSIPKS DSTTLSLILA KRSLGGSVVG YSSETEFNDT VHMRNNVVLV
     SDAFEYPLST RLAEKVVAAL AVRRSYWCAL RVEGSEVFPV MYLVMAYMNR LVFEAISPDD
     GQGTWRFEVQ RLHRVGRSPG PILLEWLKTV FRIGWKGEHV VDRWKGAGSA LEIMNDLYQM
     YNSDPKGWVP DDSHFVIPLL GAHLKPHKIV PDYLAWMAAN PPGSKRYKNE RHLLQFPFLF
     EPMRRMHNFR LMLYHQMHHE WRRSRAVREL HNHFSWLITP GSSDYRCIDE RCNHAMCERL
     RFQNRQPILS DDARHGSIRR LPSHFWNRDL YLRNRLDTSR AKFLILDIER QSILESTFDQ
     LWGREHRELL KPLKIVMRMD GKDEDAADHG GVSQEFFRLV LAKAFEPEYG LFVVTEEQTK
     MNWFKPLSLE PLQTYELLGL LFGMAVYNGI TLPVNLPFAM YQVLCGRGPF EQFVLQDAWP
     SLHKSFQQLT DWREEDGDVE EIFARDYAFS FEANGQTYTI DMLNDDSTLV DRLFYSEDSE
     QSIFTDMRRS LTPVTYSNRI DFISDYKKWL VFNSVRPQLE AFVKGFRHII SITFTSFITS
     PTLQRFVEGT RQIDASLLKA ATSYAITSPE TEPSYSDEYS SAHPTIQHFW SVVMNYDQVQ
     LQKLLTFVTA SDRVPVQGYR AIGFSIEKHG DVNMLPTSST CFGKLFLPPY ESEEAVSRML
     GIAIEEGTSG FGFM
//