ID   A0A0D2AD29_9PEZI        Unreviewed;       543 AA.
AC   A0A0D2AD29;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   RecName: Full=Carboxypeptidase {ECO:0000256|RuleBase:RU361156};
DE            EC=3.4.16.- {ECO:0000256|RuleBase:RU361156};
GN   ORFNames=PV09_04020 {ECO:0000313|EMBL:KIW04838.1};
OS   Verruconis gallopava.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC   Pleosporomycetidae; Venturiales; Sympoventuriaceae; Verruconis.
OX   NCBI_TaxID=253628 {ECO:0000313|EMBL:KIW04838.1, ECO:0000313|Proteomes:UP000053259};
RN   [1] {ECO:0000313|EMBL:KIW04838.1, ECO:0000313|Proteomes:UP000053259}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 43764 {ECO:0000313|EMBL:KIW04838.1,
RC   ECO:0000313|Proteomes:UP000053259};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Ochroconis gallopava CBS43764.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Vacuolar carboxypeptidase involved in degradation of small
CC       peptides. Digests preferentially peptides containing an aliphatic or
CC       hydrophobic residue in P1' position, as well as methionine, leucine or
CC       phenylalanine in P1 position of ester substrate.
CC       {ECO:0000256|ARBA:ARBA00025622}.
CC   -!- SIMILARITY: Belongs to the peptidase S10 family.
CC       {ECO:0000256|ARBA:ARBA00009431, ECO:0000256|RuleBase:RU361156}.
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DR   EMBL; KN847539; KIW04838.1; -; Genomic_DNA.
DR   RefSeq; XP_016214707.1; XM_016357303.1.
DR   AlphaFoldDB; A0A0D2AD29; -.
DR   STRING; 253628.A0A0D2AD29; -.
DR   GeneID; 27311993; -.
DR   VEuPathDB; FungiDB:PV09_04020; -.
DR   HOGENOM; CLU_008523_10_4_1; -.
DR   InParanoid; A0A0D2AD29; -.
DR   OrthoDB; 1647009at2759; -.
DR   Proteomes; UP000053259; Unassembled WGS sequence.
DR   GO; GO:0005773; C:vacuole; IEA:UniProtKB-KW.
DR   GO; GO:0004185; F:serine-type carboxypeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.287.410; -; 1.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR001563; Peptidase_S10.
DR   InterPro; IPR008442; Propeptide_carboxypepY.
DR   InterPro; IPR033124; Ser_caboxypep_his_AS.
DR   InterPro; IPR018202; Ser_caboxypep_ser_AS.
DR   PANTHER; PTHR11802:SF113; CARBOXYPEPTIDASE Y; 1.
DR   PANTHER; PTHR11802; SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE; 1.
DR   Pfam; PF05388; Carbpep_Y_N; 1.
DR   Pfam; PF00450; Peptidase_S10; 1.
DR   PRINTS; PR00724; CRBOXYPTASEC.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00560; CARBOXYPEPT_SER_HIS; 1.
DR   PROSITE; PS00131; CARBOXYPEPT_SER_SER; 1.
PE   3: Inferred from homology;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645,
KW   ECO:0000256|RuleBase:RU361156};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361156};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU361156};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053259};
KW   Signal {ECO:0000256|SAM:SignalP}; Vacuole {ECO:0000256|ARBA:ARBA00022554};
KW   Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           16..543
FT                   /note="Carboxypeptidase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012655595"
FT   DOMAIN          32..101
FT                   /note="Propeptide carboxypeptidase Y"
FT                   /evidence="ECO:0000259|Pfam:PF05388"
SQ   SEQUENCE   543 AA;  60651 MW;  8AAD84F4DB255370 CRC64;
     MKAIASLALI GAASAAVTNN QQPLKLPEII GQAASSWDKP LHKLEDALKS LTAEAQAVWD
     EVAMMFPEEM SKANFFSSPK PHVKRPDGEW DYITKGEDIQ NKWVINAQGV KEREIDGKLS
     NYNLRTRAVD PSSLGVDTVK QYSGYLDDEE EDKHLFYWFF ESRNDPKNDP ILLWLNGGPG
     CSSLTGLFME LGPSSITKDG KVKYNPSSWN ANASIIFLDQ PVNVGYSYSG NSVSNTVAAG
     KDVYALLTLF FKQFPEYAEL DFHISGESYA GHYIPVFAHE ILSHKKRNIN LKSVLIGNGL
     TDGLTQYQYY RPMACGEGGY PAVLDAQQCD AMDNAYPRCA SLIQGCYDSQ SVWRCVPAAI
     YCNNAMIGPY QRTGMNPYDV RVKCKNGNLC YDELDWIQGY LNRKDVMKAL GAEVSSYESC
     NFDINRNFLF QGDWMMPFHL LVPDLLAEIP VLIYAGDADF ICNWLGNKAW TEALEWPGKK
     AYGKASYDDL FLSSDKKTKI GSVKSAGNFT FIRISGGGHM VPYDQPEASL DFVNRWTSGE
     WFA
//