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Database: UniProt
Entry: A0A0D2AGV2_9EURO
LinkDB: A0A0D2AGV2_9EURO
Original site: A0A0D2AGV2_9EURO 
ID   A0A0D2AGV2_9EURO        Unreviewed;       858 AA.
AC   A0A0D2AGV2;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   07-JUN-2017, entry version 10.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=PV10_01843 {ECO:0000313|EMBL:KIV98163.1};
OS   Exophiala mesophila.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC   Exophiala.
OX   NCBI_TaxID=212818 {ECO:0000313|EMBL:KIV98163.1, ECO:0000313|Proteomes:UP000054302};
RN   [1] {ECO:0000313|EMBL:KIV98163.1, ECO:0000313|Proteomes:UP000054302}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 40295 {ECO:0000313|EMBL:KIV98163.1,
RC   ECO:0000313|Proteomes:UP000054302};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "The Genome Sequence of Exophiala mesophila CBS40295.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KN847520; KIV98163.1; -; Genomic_DNA.
DR   RefSeq; XP_016229737.1; XM_016366088.1.
DR   EnsemblFungi; KIV98163; KIV98163; PV10_01843.
DR   GeneID; 27319688; -.
DR   Proteomes; UP000054302; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054302};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054302};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    427    452       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    464    484       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    549    567       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    579    604       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    643    663       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    762    781       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    793    814       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED      101    128       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   858 AA;  97419 MW;  607F0C43E4667D8D CRC64;
     MAHKDTLFRS ANMSLTQLYI SNEIGREVVS ALGEVGSVQF RDLNAETTAF QRTFTKEIRR
     LDNVERQLKY FKAQMDKSGI AMRSHWDFDQ DMLAAPQASE IDELADRAES LEHRVSNLNE
     SYETLKKREV ELTEWRWVLK EAGGFFDRAH GQTDDIRQSI DEDDAPLLRN TEAEEGRANG
     DAHGQQQSFA VMNIGFVSGV IPREKLGAFE RILWRALRGN LYMNQSEIPE PIINPETNEE
     IRKNVFVIFA HGKEIIAKIR KISESLGADL YNVDENSDLR RDQIHEVNTR LSDLASVLRN
     TKNTLDAELT AIARSLAAWL IVIKKEKAVY NALNMFSYDQ ARKTLIAEAW VPTASLPQIR
     ATLQDVNDRA GLSVPTIVNQ IKTNKTPPTY NKTNKFTEGF QTIIDAYGTA KYQEVNPGLY
     TIVTFPFLFA VMFGDFGHGT LMAMAAAAMI YWEKPLSRSK QDELFAMAFY GRYIMLMMGI
     FSMYTGLVYN DVFSKGFTPF ASAWEFPEEG RPTSVGQLKG SYRYPFGLDW AWHGSENDLL
     FSNSLKMKLS ILMGWAHMTY ALTFSYINAR HFKSPIDVWG NFVPGMIFFQ SIFGYLSFCI
     VYKWSIDWAA VGRNPPSLLN MLIQMFLSPG TVEEGEQLYS GQAGLQVVLV LIAVINVPIL
     LLLKPLYLRW EHNKTAAQGY RGIGDTSRVT HALDDDDEDG NPEQRQNGRP SNDSDEGAMI
     TENIDDEEHE EFEFSEVMIH QTIHTIEFCL NCVSHTASYL RLWALSLAHQ QLSVVLWNMT
     LGNAFGSSGG MQVFMIVVTF FFWFVLTIAV LCVMEGTSAM LHSLRLHWVE AMSKHFIGEG
     VTFEPFSFKL LLEEEPID
//
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