ID A0A0D2AM47_9EURO Unreviewed; 540 AA.
AC A0A0D2AM47;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN ORFNames=PV07_09287 {ECO:0000313|EMBL:KIW26172.1};
OS Cladophialophora immunda.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Cladophialophora.
OX NCBI_TaxID=569365 {ECO:0000313|EMBL:KIW26172.1, ECO:0000313|Proteomes:UP000054466};
RN [1] {ECO:0000313|EMBL:KIW26172.1, ECO:0000313|Proteomes:UP000054466}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 83496 {ECO:0000313|EMBL:KIW26172.1,
RC ECO:0000313|Proteomes:UP000054466};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Cladophialophora immunda CBS83496.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00029358};
CC -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC 3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC {ECO:0000256|ARBA:ARBA00025711}.
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DR EMBL; KN847044; KIW26172.1; -; Genomic_DNA.
DR RefSeq; XP_016246388.1; XM_016396532.1.
DR AlphaFoldDB; A0A0D2AM47; -.
DR STRING; 569365.A0A0D2AM47; -.
DR GeneID; 27348481; -.
DR VEuPathDB; FungiDB:PV07_09287; -.
DR HOGENOM; CLU_018822_0_1_1; -.
DR OrthoDB; 5474505at2759; -.
DR UniPathway; UPA00363; UER00861.
DR Proteomes; UP000054466; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR045190; MCCB/AccD1-like.
DR PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR PANTHER; PTHR22855:SF46; METHYLCROTONOYL-COA CARBOXYLASE; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054466}.
FT DOMAIN 28..280
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 283..540
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
SQ SEQUENCE 540 AA; 58900 MW; 71508B78724CFC72 CRC64;
MAHAAGFPVV ESVLDVTREP YRSNREAWKP VMEEFSQNLR RTTSEGNPQA IDKHEKRGQL
LARDRISLLL DPDSSFLELG TFTGFDLDDS SPCASLLAGI GSISGRICLV IAHIATQSGG
AWNELTVIKQ NRVTEIASEN DLPLVALVQS AGVFLPQQFR VFHKGGQIFR DLAMRTQNGH
ASCAIVFGSS TAGGAYHPGL SDYTIFVENQ AQVFLAGPPL VKMATGENIV AEELGGARVH
GTVTGLADQI AFDEFDAVRK AREWVSTLSQ RNQPAQPMRP PLAPRYPIED IFSIVNPDVR
KPFDMKEVVL RLVDESRLAV FKPEYGSNLL TGWAYIMGMR VGIIANQTPI INPDEASKGT
QFIRLCNQQN TPIAFLHNVT GFMVGSKAEH AGIIKKGAQF VSAVSCSKVP HISIILGASY
GAGNYAMCGR SYRPRFLFTW PTGRCSVMGP EQLSGVMAQV EANSARSKGV VLKPEEVEAR
VQRLQKEVQR DSSAYRTSAY MLDDGVIDPR DTRDVLAMCL EVVQTPGVQG SAGHRALARI
//
