ID   A0A0D2CZA6_9EURO        Unreviewed;       543 AA.
AC   A0A0D2CZA6;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   RecName: Full=PNPLA domain-containing protein {ECO:0000259|PROSITE:PS51635};
GN   ORFNames=PV04_02773 {ECO:0000313|EMBL:KIW70511.1};
OS   Phialophora macrospora.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Phialophora.
OX   NCBI_TaxID=1851006 {ECO:0000313|EMBL:KIW70511.1, ECO:0000313|Proteomes:UP000054266};
RN   [1] {ECO:0000313|EMBL:KIW70511.1, ECO:0000313|Proteomes:UP000054266}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 27337 {ECO:0000313|EMBL:KIW70511.1,
RC   ECO:0000313|Proteomes:UP000054266};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Capronia semiimmersa CBS27337.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable lipid hydrolase. {ECO:0000256|ARBA:ARBA00002682}.
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DR   EMBL; KN846957; KIW70511.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0D2CZA6; -.
DR   STRING; 5601.A0A0D2CZA6; -.
DR   HOGENOM; CLU_009031_5_0_1; -.
DR   OrthoDB; 154387at2759; -.
DR   Proteomes; UP000054266; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006641; P:triglyceride metabolic process; IEA:UniProt.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR002641; PNPLA_dom.
DR   InterPro; IPR021771; Triacylglycerol_lipase_N.
DR   PANTHER; PTHR14226; NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER; 1.
DR   PANTHER; PTHR14226:SF44; TRIACYLGLYCEROL LIPASE 3; 1.
DR   Pfam; PF11815; DUF3336; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           17..543
FT                   /note="PNPLA domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002240098"
FT   DOMAIN          174..370
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
SQ   SEQUENCE   543 AA;  62033 MW;  F6A74C435A23DF7F CRC64;
     MLILFIILGH VRSVLRSLLL LVWIEPWTQP HVNGETPPLT YEAWYDAQSD SDAIRGVDDW
     AVMDRHPCYD WQVLRTMKKD LERCRRLGDE RGLCSQLRAQ SSRNMCRVLS PALYRRSPIQ
     TKKLIHDYVR EVQQCIRYLG ERTGVTNGAA SVVPAQERRQ VIVDMRTTLG RTSLVLQGGA
     MISMCHLGVV KALYKQELLP RIITGTSSGA LIAAHICVTK DEDLLGVLEA THINLDAFLR
     SQNSHPTSVS SSWLRSSFFA TIKRRYRRYR TSHHVFDIDV LQECTRDNLG DITFEEAYHK
     TGRILNITIA MSEVTGTPQL LNYLTAPHVL VRSAVVASIA TSKAMYAPVQ LLCKDPAGEI
     VMYFAADFSE KDHDHRHSTV HAEAPLTRIG ELFNVNHFIV SQTRPYIAPF IQLQKYADRH
     QPLGLLVRFT LSEWLHWLEV LNRFNMLPTF LQRVLMDEVV PTMASWSKVS ITPQIGLCDF
     FRTFETPTPA RLQYWSARGE QCTWPYICEL KVRCDIELEL DAAYTSLRRR GGIGSTIRHR
     ADP
//