ID A0A0D2D3V4_9EURO Unreviewed; 591 AA.
AC A0A0D2D3V4;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN ORFNames=PV06_10873 {ECO:0000313|EMBL:KIW36975.1};
OS Exophiala oligosperma.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=215243 {ECO:0000313|EMBL:KIW36975.1, ECO:0000313|Proteomes:UP000053342};
RN [1] {ECO:0000313|EMBL:KIW36975.1, ECO:0000313|Proteomes:UP000053342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 72588 {ECO:0000313|EMBL:KIW36975.1,
RC ECO:0000313|Proteomes:UP000053342};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala oligosperma CBS72588.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
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DR EMBL; KN847347; KIW36975.1; -; Genomic_DNA.
DR RefSeq; XP_016257191.1; XM_016412466.1.
DR AlphaFoldDB; A0A0D2D3V4; -.
DR STRING; 215243.A0A0D2D3V4; -.
DR GeneID; 27362947; -.
DR VEuPathDB; FungiDB:PV06_10873; -.
DR HOGENOM; CLU_013399_0_1_1; -.
DR OrthoDB; 374620at2759; -.
DR Proteomes; UP000053342; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053342}.
FT DOMAIN 139..278
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 346..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 557..591
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 591 AA; 63960 MW; E2058088876A6F8A CRC64;
MAGDRRSESN PFSDNAAIQD EREAMVESTL SVGRNATLTL GTDAVIVLDD GLRGDSGFDC
FGLFKRTTNT RSIPFFNVLW AELVKGELTI RYAKPSSKSA NAPVSVAYIN YTIESTTAVE
EKALRWIDRL LDRAYGKAQR NKRIKLLINP FGGAGKAAKI YAKAIEPIFA AARCELDVER
TTHSGHAVEI CADLDINAFD VVASASGDGL PHECVNGLAR KPNAAEALRK VAVVQLPCGT
GNAMSWNLTG TAEPSAAALC IVKGIRTPMD LASVTQGNTR TLSFLSQSLG IVAESDLGTE
NIRWMGDARF TFGFLVRLLG KTLYPIELAV KTEIENKEDI RRHYAEHRAR RRSQGSALSH
DDLDGPLDTS TGLGLPPLKY GTVEDPLPEN EGWTPMAYYP NMGNFYCGNM AMMAADAPFF
PASLPCDGLL DLITIDGDIK RTKAVDLLLS VPKGTFFDKE CVRYRKVSAI RVVPKFGNMV
DQSDNEARQN KLGKVLDRMG VSGNGRNASR DGGYFSVDGE KLPFQPFQVE VHKGLATVLS
KNVGMYECMG PRGWEDVPVS TTTTGHVSTS ASGTASGPGH DADDTDVRGQ L
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