ID A0A0D2DDA3_9EURO Unreviewed; 1276 AA.
AC A0A0D2DDA3;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=CSC1/OSCA1-like 7TM region domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV05_00522 {ECO:0000313|EMBL:KIW60292.1};
OS Exophiala xenobiotica.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=348802 {ECO:0000313|EMBL:KIW60292.1, ECO:0000313|Proteomes:UP000054342};
RN [1] {ECO:0000313|EMBL:KIW60292.1, ECO:0000313|Proteomes:UP000054342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 118157 {ECO:0000313|EMBL:KIW60292.1,
RC ECO:0000313|Proteomes:UP000054342};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala xenobiotica CBS118157.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KN847317; KIW60292.1; -; Genomic_DNA.
DR RefSeq; XP_013320876.1; XM_013465422.1.
DR AlphaFoldDB; A0A0D2DDA3; -.
DR GeneID; 25322430; -.
DR HOGENOM; CLU_002458_2_0_1; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000054342; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR PANTHER; PTHR13018:SF20; SPORULATION-SPECIFIC PROTEIN 75; 1.
DR Pfam; PF14703; PHM7_cyt; 2.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054342};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 27..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 168..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 651..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 708..728
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 749..776
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 796..825
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 871..889
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 909..931
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 943..961
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 27..188
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 212..288
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 560..642
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 656..928
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 1196..1267
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 310..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1033..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1086..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 417..431
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1033..1054
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1090..1117
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1136
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1276 AA; 144530 MW; F0DABFC85F6A4DFC CRC64;
MSLNSTLDLG GSTTASESKS GQTASQFAAS LVTSIAIFGI QVALFLLIKD RFARIYQPRT
YLVPERERTK PTDPGWWKWI KPVFVTSNSE FVQKCGLDAY FFLRYLRTLL KIFVPAAMVI
LPILIPLNVV DGRGGRYATG RHENSTNVTG LDQLAWGNVA PDHTGRYWAH WLLALGLIVW
VCYVAYDELR NYIRMRQAYL TSPQHRLRAS ATTVLVSAIP QKWCNVEALD GLYDVFPGGL
RNIWINRNFD ELSEKIKRRD KLAATLEAAE TELIKKCFKK NEENIKKADK EAGKKLSKQE
KELRATIRNE EGDQAAHGHG ITTGNPHQVN HRLRDVLDGP SDRSMSPSDG EEDVVEEPRH
TRRAIPIPVI GEGISAVTHG LDTIGNRLLG GIRGVNKGVN DTIDTTNGFV ASEPKQASSS
DDDEPSRQHD NSGSGTHRNA FHQEKKHRAH DATAGAQPAD GDRGRSKEKL GRYDRPSSPI
SQSSTMRDEK TRPEKPLTKF EKFKKAIGLG SEEKDPVDYP PAFEWNFEQD PDDAVWRRYL
TEKDRETMRL PIFGWQWMPS LPLMGEKVDT IRYCRKEVAR LNVEIEDDQA HPERFPLMNS
AFIQFNHQVA AHMACQAVSH HVPKHMAPRM VEIDPNDVIW DNMSMPWWQR YVRTGGVVAI
VTGMIILWAV PVAFTSALSQ LDTAAKTWTW LHWVLSIPAW FRSVIQGVLP PALLGLLTFL
LPLILRFLCK VQGIQSGMLV EISVQRYYFA FLFVQLFLVV SIASALTQFF ALFTSVDGFT
NIPALLGTNI PKASNYFFSY MLLQALSVSA GALVQVGSLI GWFILAPLFD STARAKFKRQ
TELSNVRWGT FFPVYTNLAC IGLIYSVISP LILIFNVITF SLFWFVYRYN TLYVTRFTRD
TGGLLYPNAI NTTFVGLYVM EIALIGMFFL VRDSAGSVAC SGQAIGMIII LILTAGYQLL
LNEAFSPLFR YLPITLEDDA VRRDEEFARA MQNKQGLLEA DNQVEDLEDQ LERKERQSME
EDRNEQEYEL QRIKADRDAR LEKQETHKPD LEPSEYQNPE IVMNLDQDSR GLRIAKSVTQ
KATDTTKHLV VRNLGRKERP KSWADRDNER NRRASNFGEW EDTPSQGRSR APSEVPAQGH
TTHKRRVSPP RDVFNKLNNF NPITGTEKDI EAQRAARNQL ADALFGGVSD ELEDLTPEER
DRLVQRAFQH SALRARRPVI WIPRDELGVS DDEVHRMGRF SSHIWVSNVR QGLDSKGRCV
YSGAPPDFSE VDLIQL
//
