ID A0A0D2DYD0_9EURO Unreviewed; 1229 AA.
AC A0A0D2DYD0;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Rho1 guanine nucleotide exchange factor 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV06_00288 {ECO:0000313|EMBL:KIW47605.1};
OS Exophiala oligosperma.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=215243 {ECO:0000313|EMBL:KIW47605.1, ECO:0000313|Proteomes:UP000053342};
RN [1] {ECO:0000313|EMBL:KIW47605.1, ECO:0000313|Proteomes:UP000053342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 72588 {ECO:0000313|EMBL:KIW47605.1,
RC ECO:0000313|Proteomes:UP000053342};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala oligosperma CBS72588.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN847332; KIW47605.1; -; Genomic_DNA.
DR RefSeq; XP_016267821.1; XM_016400768.1.
DR AlphaFoldDB; A0A0D2DYD0; -.
DR STRING; 215243.A0A0D2DYD0; -.
DR GeneID; 27352362; -.
DR VEuPathDB; FungiDB:PV06_00288; -.
DR HOGENOM; CLU_001251_6_0_1; -.
DR OrthoDB; 5100844at2759; -.
DR Proteomes; UP000053342; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd04435; DEP_fRom2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053342}.
FT DOMAIN 363..438
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 531..722
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 908..1205
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 43..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..135
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..280
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1229 AA; 138760 MW; FEB859D833986733 CRC64;
MADYGSPDSR YHASRSPNYG GPPADRQRDA AFHNIFGGAP PPGRSQTMTT QSSGMMYDRS
NSLSMGMQPA QHTMSMRQGP PPPMRHPPQN YDRANGIVPA QPYMNGTGNP RPMPHNPPPM
FPDRRPYPPP QRMDPRSGGP HMMPNPYERR PLPNRMPPPA LNNDSYRSRS MVRPGEPTIG
YRPPPNSFQQ GTAGAIRQQP YAGMGPMGPS RTTAQGRHIP ERPDDRAMSM GTYSFDRDHT
QQLTSGRVVP GRRREAEGDP FADQVSVQGS FNSTSSPAYV PTHRARRPSE SSAAPPRTVS
SASIASGSSD LTGTTMNGSR SDSMKQRPAP SSHSSSQSTT STVVQRKSPL VYPALLSRVA
SAFQERIGVG DREKNDLSYK NAFTGAEAVD LIAYIIKTTD RNLALLLGRA LDAQKFFHDV
TYEHRLRDAP GEVYQFKETL GEEASSKDVN GVFTLLTECY SPTCTRDNLC YSIACPRRLE
QQARLNLKPQ PGLRHSNSRG SLHDNDDQEQ KLWINSVPKE VADRIDDREK KRQEVISEIM
YTERDFVKDL EYLRDFWIRP LRGLGNVASP IKEEKREKFV RTVFGNCLEV LAVNGKFADE
LSKRQKEQHV VQCIGDVFLK WVPQFDPFIK YGANQMYGKY EFEKEKGANP AFSRFVDETE
RLKESRKLEL NGYLTKPTTR LARYPLLLDN VLKYTKDDNP DKKDIPKAIG IIKDFLARVN
AESGKAENHF NLLQLNQSLK WNPGEYTDLK LTEENRVILT KMGFKKSPTD TAEVQVYLFD
HAVLMCRVKT VNKREELRVY RKPIPLELLV IAEMDQVIPR LGIAKRPSSS LIPGAKSSAS
STPGQKEVYP VTFRHLGKGA YELQLYATSI TQRKKFIELV EEQQSKLRER SSDFYTKSIL
CEGFFNAQNR VNCLVPTDGG RKLIIGTDNG IYIADRFTKD KSIKPRRILD ATQVSQIDTL
EEYRLLLVLS NKTLTSYPFE ALDANNQNPL ATRPRKIQGH ANFFKAGIGL GRHLVCSVKT
SALSTTIKVY EPMDDLTKGK KKPAISKMFA SGQDALKPFK EFYIPAESTS VHYLRSTLCV
GCARGFEVVS LETTERQSLL DQADTSLDFV TRKENVKPIH IERLNGEFLL NYSDFSFFVN
RNGWRARQDW KITWEGTPQA FALNYPYILA FEPSFIEIRH IETSELIHVM TGKNVRMLHS
STREILYAYE DESGEDVIAS LDFWTQAQA
//
