ID A0A0D2EFC1_9EURO Unreviewed; 571 AA.
AC A0A0D2EFC1;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=4-coumarate-CoA ligase {ECO:0008006|Google:ProtNLM};
GN ORFNames=PV05_06525 {ECO:0000313|EMBL:KIW54143.1};
OS Exophiala xenobiotica.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=348802 {ECO:0000313|EMBL:KIW54143.1, ECO:0000313|Proteomes:UP000054342};
RN [1] {ECO:0000313|EMBL:KIW54143.1, ECO:0000313|Proteomes:UP000054342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 118157 {ECO:0000313|EMBL:KIW54143.1,
RC ECO:0000313|Proteomes:UP000054342};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala xenobiotica CBS118157.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KN847320; KIW54143.1; -; Genomic_DNA.
DR RefSeq; XP_013314727.1; XM_013459273.1.
DR AlphaFoldDB; A0A0D2EFC1; -.
DR STRING; 348802.A0A0D2EFC1; -.
DR GeneID; 25328433; -.
DR HOGENOM; CLU_000022_59_2_1; -.
DR OrthoDB; 1404660at2759; -.
DR Proteomes; UP000054342; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:UniProt.
DR CDD; cd05911; Firefly_Luc_like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR24096:SF149; 4-COUMARATE--COA LIGASE 1-RELATED; 1.
DR PANTHER; PTHR24096; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054342};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 73..97
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..420
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 471..550
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 571 AA; 63785 MW; B3B922D612B07A13 CRC64;
MPYKSRWTVA VPECSLPTFL FKSPTHALGS QRCFSEAARP DTHYFTRDTF RLWAQRFALG
LQRSKHFKKG DRILLFSGND LFVPVVFMGI LCAGGIFTGA NPTFVARELA HQLRDSGATY
LLCADGSIDT GIEAARLAGL DPSERVFMYN ASIYDDDQGT TKSRPGIKGC KYWSELVAPA
EDAKGFQWDN LTGTGECDRT LALNYSSGTT GVPKGVEITH RNYISNTVQV AHIARQHPEY
EARNARARWL CFLPLYHAYG QTYYVAGAFN RAVPVYVMPK FDFEKMLEYT QRFRITDFTL
VPPIAVLLAK HPAVEKYDLS SVENIGCGAA PLGRDVCLQV ERRLGNGLNL KQGWGMTECT
CSLLGWDINK QSFSAAVGEP NANCEAKIMS EDGTHEITAR GPEHVGELWC RGPNVMKGYW
RNPKATAETL TPDGWLKTGD IAYVDEQGMF FIVDRKKELI KVKGNQVAPA ELEALLLEHE
AIADAAVIGM PTDDGDEKPR AFIVRQPGSR HQQLTEDEVK RFVEGKVVRY KRLAGGVEFV
EAIPKNPSGK ILRRQLRDTT RERLRRDGAR L
//
