ID A0A0D2EPE6_9EURO Unreviewed; 828 AA.
AC A0A0D2EPE6;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Transcription factor BYE1 {ECO:0000256|ARBA:ARBA00021616};
GN ORFNames=PV05_11343 {ECO:0000313|EMBL:KIW49689.1};
OS Exophiala xenobiotica.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Exophiala.
OX NCBI_TaxID=348802 {ECO:0000313|EMBL:KIW49689.1, ECO:0000313|Proteomes:UP000054342};
RN [1] {ECO:0000313|EMBL:KIW49689.1, ECO:0000313|Proteomes:UP000054342}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 118157 {ECO:0000313|EMBL:KIW49689.1,
RC ECO:0000313|Proteomes:UP000054342};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Exophiala xenobiotica CBS118157.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of transcription elongation.
CC {ECO:0000256|ARBA:ARBA00002311}.
CC -!- SIMILARITY: Belongs to the BYE1 family.
CC {ECO:0000256|ARBA:ARBA00011050}.
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DR EMBL; KN847323; KIW49689.1; -; Genomic_DNA.
DR RefSeq; XP_013310273.1; XM_013454819.1.
DR AlphaFoldDB; A0A0D2EPE6; -.
DR STRING; 348802.A0A0D2EPE6; -.
DR GeneID; 25333251; -.
DR HOGENOM; CLU_009292_0_0_1; -.
DR OrthoDB; 5491784at2759; -.
DR Proteomes; UP000054342; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR CDD; cd15550; PHD_MLL5; 1.
DR CDD; cd21538; SPOC_TFIIS; 1.
DR Gene3D; 1.10.472.30; Transcription elongation factor S-II, central domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR012921; SPOC_C.
DR InterPro; IPR003618; TFIIS_cen_dom.
DR InterPro; IPR036575; TFIIS_cen_dom_sf.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11477:SF20; PROTEIN PARTNER OF SNF, ISOFORM B; 1.
DR PANTHER; PTHR11477; TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF20826; PHD_5; 1.
DR Pfam; PF07744; SPOC; 1.
DR Pfam; PF07500; TFIIS_M; 1.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00510; TFS2M; 1.
DR SUPFAM; SSF46942; Elongation factor TFIIS domain 2; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51321; TFIIS_CENTRAL; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054342};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00146}.
FT DOMAIN 54..106
FT /note="PHD-type"
FT /evidence="ECO:0000259|PROSITE:PS50016"
FT DOMAIN 235..365
FT /note="TFIIS central"
FT /evidence="ECO:0000259|PROSITE:PS51321"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 324..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 431..446
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..691
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 731..745
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 828 AA; 89970 MW; 93C0EFC28113E965 CRC64;
MADEPRRSGR ATKGQYTKDR DIQEDAPKKK GKGKSSKAKA VEEEEEGDEE SEEIIRCVCG
TYEEEEDVPR AMICCDRCEA WQHNSCMGLE EDYQPETYFC EQCKPEDHKE LIAAMARGER
PWDEALRKFE ERTKKKGKKG RKSGGARTSE VGPRASQEAK DQTPQPTATG QKRKLEESPS
VPELKNKKAR GTPAADTNGA KAATPARKPS ETPSKPASKS EYPVVTDVKE LANSSRRQAA
STLIKLMESQ IKEASKQGEY TAPSGSSTQA ISNGIGLRLE SALYHIHAGG SGEPNEAYKN
QLRSIPFNLK KNHALAVRLL SGDLSPEELA GMDPKDMASE EQKKKDAATM KELEKQHTIV
EEQGPRIRRT HKGEEYVDES RQVAAESQTS NAPVRRPSGI EQSDAESKSP VIKSPSEIPG
AGRSRPKPSV DTKRQSSSNF DIDKVWSNVQ GSPDVDGHRF GDLSQQSPGM AVREPMGPGA
KADADIDELL KDEEAESPPY SPKESAEADG VVWRGTINGG NLGRFRATAR HAAGATPDSD
TLRMTYRDVL PQEISIGGRI QPPKADEYLC GLEYSNTSDL VIVYMPEPQN SPDQEEFDKL
FRYFKSKDRF GVGVQHHNAA IKDIYLIPLN EGQELPTFVK KLETDFSDPA RERMLLVPIV
IKNSELPHMQ GANLDGTPTA ASPSSRGPAV AQTPITPHDG SFEPPQTGIY SQSPAPVPGQ
YGANGAPPQM MPTPGFAPPG QPYPGYGQPS QLQPQSPATM TAQKILGPLA SSPAVVQLCA
QAPNAGEIEF KIIKECIEKN PEAANRLDVL TTMLQESSIA AGGQGGGI
//
