ID A0A0D2F3Q7_9EURO Unreviewed; 853 AA.
AC A0A0D2F3Q7;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=DUF221-domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=Z517_04342 {ECO:0000313|EMBL:KIW81317.1};
OS Fonsecaea pedrosoi CBS 271.37.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW81317.1, ECO:0000313|Proteomes:UP000053029};
RN [1] {ECO:0000313|EMBL:KIW81317.1, ECO:0000313|Proteomes:UP000053029}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW81317.1,
RC ECO:0000313|Proteomes:UP000053029};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CSC1 (TC 1.A.17) family.
CC {ECO:0000256|ARBA:ARBA00007779}.
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DR EMBL; KN846971; KIW81317.1; -; Genomic_DNA.
DR RefSeq; XP_013285125.1; XM_013429671.1.
DR AlphaFoldDB; A0A0D2F3Q7; -.
DR GeneID; 25303832; -.
DR VEuPathDB; FungiDB:Z517_04342; -.
DR HOGENOM; CLU_002458_2_1_1; -.
DR OrthoDB; 54187at2759; -.
DR Proteomes; UP000053029; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005227; F:calcium-activated cation channel activity; IEA:InterPro.
DR InterPro; IPR045122; Csc1-like.
DR InterPro; IPR003864; CSC1/OSCA1-like_7TM.
DR InterPro; IPR027815; CSC1/OSCA1-like_cyt.
DR InterPro; IPR032880; Csc1/OSCA1-like_N.
DR InterPro; IPR022257; PHM7_ext.
DR PANTHER; PTHR13018:SF26; DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G10920)-RELATED; 1.
DR PANTHER; PTHR13018; PROBABLE MEMBRANE PROTEIN DUF221-RELATED; 1.
DR Pfam; PF14703; PHM7_cyt; 1.
DR Pfam; PF12621; PHM7_ext; 1.
DR Pfam; PF02714; RSN1_7TM; 1.
DR Pfam; PF13967; RSN1_TM; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053029};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..46
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 101..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..458
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 479..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 544..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 589..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 668..689
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..173
FT /note="CSC1/OSCA1-like N-terminal transmembrane"
FT /evidence="ECO:0000259|Pfam:PF13967"
FT DOMAIN 196..375
FT /note="CSC1/OSCA1-like cytosolic"
FT /evidence="ECO:0000259|Pfam:PF14703"
FT DOMAIN 387..659
FT /note="CSC1/OSCA1-like 7TM region"
FT /evidence="ECO:0000259|Pfam:PF02714"
FT DOMAIN 748..838
FT /note="10TM putative phosphate transporter extracellular
FT tail"
FT /evidence="ECO:0000259|Pfam:PF12621"
FT REGION 259..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..834
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 853 AA; 95714 MW; 9535F3298F0832EB CRC64;
MDVLKEKTPG SGGHRSQHSS SFAAIGAALI PTAITAAVFL LAFAAIRSRY RNIYAPRTYF
RTIDHRDRTP SSSHTSVSWW HDFRALDDKF ILRHSSLEAY LFLRFLRLIV LICVVGCFLT
WPILFAVNAT GGGDATQLDR ISFSNVADGK RLYAHAAVAW VFFGFILLLV TRERLFVIGL
RQAYQTIPVN ASRLSSRVVL YLSVPPAGLR EENLRRYFGE NAVRSWVVSN QSDLEKLVQK
RDKKIDQLEE SELQLLKNAN RSKDEARDSG DASSSQQPKP ANEAHRPKHK SKYLLGEKID
SISRLREDIT GLVSDVDQVR QADSNAPGKR TGAIFVEFKD QVSAHQAFQQ VRHPSPLTLQ
PKYIGIQPKE VLWQNLNLDP SVRITYSYIA IALAVATIIF WSIPVGIIGT ISNINYLTDK
FHFLRFINNL PDPILGLLTG LVPPLLLSSV VSYVPYLFQY VARLSGQPTS KSAVEWAQTW
YFAFQVIQVF LITTFSSGAA ALATKVANQP TTVPTLLAKN LPKASNFYLT YFIIQGLGTA
SKNILNYTDL FSFLFFYYGM NKTPRQKFNT YAQMKGISWF NVYPKFTNLA VIAIAYSCIA
PLVLGFAAIG LFLFYLSYRY NLLYVIQVKT ETRGESYTRS LQHLMTGVYL AELCLIGLFG
IKKVAGPSTL LTVLLVVTAL YHLTVNQYLS PLEKYMPVDV LSEEDEERPL LGLSTERNHT
AQADQSSGYK LGSRKVPAVL LDPLASLLEP RIFASQDSLR PWLQDPEGES EEVNSYSEEQ
LKNAYLPPAL TSKTPKIWLP KDRKGLSKRE VDANEKAGLP STDEGAELGP SNEILWNQDD
FTTVPIFKQA TRY
//
