ID   A0A0D2FD78_9EURO        Unreviewed;       611 AA.
AC   A0A0D2FD78;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   13-SEP-2023, entry version 33.
DE   RecName: Full=methionine--tRNA ligase {ECO:0000256|ARBA:ARBA00012838};
DE            EC=6.1.1.10 {ECO:0000256|ARBA:ARBA00012838};
GN   ORFNames=Z517_03832 {ECO:0000313|EMBL:KIW84582.1};
OS   Fonsecaea pedrosoi CBS 271.37.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX   NCBI_TaxID=1442368 {ECO:0000313|EMBL:KIW84582.1, ECO:0000313|Proteomes:UP000053029};
RN   [1] {ECO:0000313|EMBL:KIW84582.1, ECO:0000313|Proteomes:UP000053029}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 271.37 {ECO:0000313|EMBL:KIW84582.1,
RC   ECO:0000313|Proteomes:UP000053029};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Fonsecaea pedrosoi CBS 271.37.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363039}.
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DR   EMBL; KN846970; KIW84582.1; -; Genomic_DNA.
DR   RefSeq; XP_013288390.1; XM_013432936.1.
DR   AlphaFoldDB; A0A0D2FD78; -.
DR   STRING; 1442368.A0A0D2FD78; -.
DR   GeneID; 25303322; -.
DR   VEuPathDB; FungiDB:Z517_03832; -.
DR   HOGENOM; CLU_009710_9_0_1; -.
DR   OrthoDB; 166496at2759; -.
DR   Proteomes; UP000053029; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004825; F:methionine-tRNA ligase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006431; P:methionyl-tRNA aminoacylation; IEA:InterPro.
DR   CDD; cd00814; MetRS_core; 1.
DR   Gene3D; 2.170.220.10; -; 1.
DR   Gene3D; 3.40.50.620; HUPs; 1.
DR   InterPro; IPR014758; Met-tRNA_synth.
DR   InterPro; IPR023457; Met-tRNA_synth_2.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR033911; MetRS_core.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   NCBIfam; TIGR00398; metG; 1.
DR   PANTHER; PTHR43326:SF1; METHIONINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR43326; METHIONYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   PRINTS; PR01041; TRNASYNTHMET.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|RuleBase:RU363039};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363039};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363039};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU363039};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW   ECO:0000256|RuleBase:RU363039};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053029}.
FT   DOMAIN          60..429
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
SQ   SEQUENCE   611 AA;  69793 MW;  D46B9D415DDD16C3 CRC64;
     MLALERNARS FFLQCRASAR CQPWRPVLPR GNSQRRTLAA AIEPESSTNA YAHALAGKPY
     YVTTPIFYVN SGMSPHVGHL YTLVLADVLK RWAKLRGDTR ATLLTGTDEH GMKVQKAAQK
     ANTDVKLFCD HHAEQFKALC DAANIDYDRF IRTTDEDHKD VVRYVWEELN RAGFIYEAKH
     EGWYSVSDET FYPSTQVHKV LDPSTGITKI VSIETGKDVE WTSEMNYHFR LSEFQAPLLK
     YYENHAGAIV PKQRMAFIMD EIRSGLKDLS VSRPSSRLTW GIQVPGDESQ TIYVWLDALF
     NYLTMTGYPF VNRNDANMMW PPNCQVIGKD IIRFHTIYWP AFLMALNLPV ADRFLTHAHW
     TMNNEKMSKS AGNGVNPFYA MDRFGVDCIR FFMAHNGGIV DDATYDNSFI EETYNHLLRG
     GLGNLIHRVY KSKHFDVRGA VKLVKEDENF SKFITRDQWS ASDMEMKAIH ANLRGHHARL
     CSVREIADNH MKEPDPRKAV QSICELIGET NKLFHNSEVW KLIKSTDPET RRIANYILFT
     SADSIRVMAI LLQPFMPQRM KAALDLMEVD ESRRTFDDAV FGADFTYGPP ALGPDAKAST
     EVVFPMLLSV H
//