ID   A0A0D2GUG5_9EURO        Unreviewed;      1643 AA.
AC   A0A0D2GUG5;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   RecName: Full=Ras-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=Z520_11029 {ECO:0000313|EMBL:KIX93175.1};
OS   Fonsecaea multimorphosa CBS 102226.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX   NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIX93175.1, ECO:0000313|Proteomes:UP000053411};
RN   [1] {ECO:0000313|EMBL:KIX93175.1, ECO:0000313|Proteomes:UP000053411}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 102226 {ECO:0000313|EMBL:KIX93175.1,
RC   ECO:0000313|Proteomes:UP000053411};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KN848096; KIX93175.1; -; Genomic_DNA.
DR   RefSeq; XP_016627298.1; XM_016781520.1.
DR   STRING; 1442371.A0A0D2GUG5; -.
DR   GeneID; 27716775; -.
DR   VEuPathDB; FungiDB:Z520_11029; -.
DR   OrthoDB; 12619at2759; -.
DR   Proteomes; UP000053411; Unassembled WGS sequence.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR   GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR   CDD; cd21206; CH_IQGAP; 1.
DR   CDD; cd05127; RasGAP_IQGAP_like; 1.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR000593; RasGAP_C.
DR   InterPro; IPR001936; RasGAP_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR   PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR   Pfam; PF00307; CH; 1.
DR   Pfam; PF00616; RasGAP; 1.
DR   Pfam; PF03836; RasGAP_C; 1.
DR   SMART; SM00033; CH; 1.
DR   SMART; SM00015; IQ; 8.
DR   SMART; SM00323; RasGAP; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF143885; RGC domain-like; 1.
DR   PROSITE; PS50021; CH; 1.
DR   PROSITE; PS50096; IQ; 11.
DR   PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053411}.
FT   DOMAIN          257..363
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          1007..1223
FT                   /note="Ras-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50018"
FT   REGION          1..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          407..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1468..1495
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        7..93
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1643 AA;  188343 MW;  F2B4B02717014D1A CRC64;
     MSHYALRRAQ TDYQSGFPQR QTSSASTASS AYSGASSAFL PSRTSTVTST NSSIYARGSP
     GHKRTNTTIE DMTPTRAYGG SSSVENSPDH VYRNIRQSLR PLPQAPSPTS TPNARRPSPY
     HARAHTIDRF PQISSEDPFV DKHLHEHHQE THQSKTHTHQ GLPNPHANTF KAPDLRELQK
     SSTTHLKTLS RFAQDGDAEE FGIAAPGQSV TGLHNRRQLK RTDSVAPGAR SVAKSYGWGE
     RNWMDKQRQF LQAYEYLCHI GEAKEWIEDI INKPIPPIVQ LEEALRDGVT LAEIVQAFHP
     DQVLRIFRNP KLQFKHSDNI VLFFRFLEDV GLPDLFRFEL IDLYEKKNIP KVIYCIHALS
     WLLYRKGMVD FRIGNLVGQL EFEHHELEQT QRGLDKAGIS MPSFSGMGAS FGEPEPEPEP
     VETEDERIDK ELNEQEAVIS DFQTQVRGAL VRLRLGDVMQ RLWDAEDLIV DIQSRVRGDW
     ARQVADYRLH MQRFATNLQA ATRGFLVRVR QEKKAQQWRS REKDVLKLQS LFRAGQARTE
     TRAIKSRVQT HEAGIRNLQA AIRGALSRRD AFDQYEATRT AEKEVISLQA AIRGMLTRAG
     LQDDREFLEN QSYAITQVQA GARSMLARIT QNKLRERLLN STLAWASLQA IIRAGRVRTR
     LAGLKQSLRS QSASISKFQA ILRGANAREA FSSLKLSLLQ QSTKTIPLQA AIRGFTVRNH
     LQQQQQALER HASKFIQLQA LSRGALVRIQ TGELLTELGE TEDEAIQLQA LIRAMLCRSH
     VGDLLSELET YDESIIELQA LMRAAAIRSQ FAEKKRYFKE NMEKVIKIQS VVRAKIQGKA
     YKSLTAGKNP PVGTLKGFVH LLNDSDFDFE EEVEFERLRK TVVQHVRQNE LADQYITQLD
     IKIALLVKNK ITLDEVVKHQ RHFGGHVGAL LPNSDIASKD PFDLKALNKT SRRKLEHYQE
     LFFLLQTQPQ YLSRLLRRIR EQATAEKECD RVKHLVMGIF GYAQKRREEY YLVKLITRSI
     KEEVDCSASL QDYLRTNSFS NKLFGAYSKS PRDRKFLRDI LGPLVKENII DNTTLDLESD
     PLQIYVSAIN NEELRTGQRS QRDPNVPREV AIRDPETRAT FIAHMQDLRD ITDQFFLCLE
     DCLHRMPFGV RFVVRQTYEH LIARFPGEEA DFVLQLVGQW LWRHYLQPAL LEPEKFGVAD
     RAMTQEQKRN LGEIAKVLNQ AASGREFGGD NVYLQPLNNY VRESIGRFAA IWSHVISIPP
     AEEHYDIDEF NDLYAKTKPT LYIKMADIFS IHKLLSQEIS SICPNQDDVL RDILRELGSV
     QSNESELRGV SSSEISLTLT PKLLNSEDPD ADVKTLLTET KRCVLYIIRV QSGANLLEIL
     VKPITPEDEE KWETLVNDEL RAGNGRRGAY TDVHNHLDIS TLSYPDLKRI ALENILQLES
     VGRLTRSNQY QDLLNAIAID IRTKHRRRLQ RQRELENVKT TLARLNEQAL YLEQQLKTYN
     DYIEQAMVTL QNKKSKKRFV MPFSKQWEHE RELQRSGRSF KFGSYKYSAR TLADKGVLVH
     WRGYHERQWD RVDLTFSSNE VGVFTIDGSS GNMMIPGANA QVPLDDLLQA QFNNTQFMEF
     FEGALRVNVN LFLHLIMKKF YNE
//