ID A0A0D2I659_9EURO Unreviewed; 1055 AA.
AC A0A0D2I659;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 22-FEB-2023, entry version 22.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=Z518_09014 {ECO:0000313|EMBL:KIX01289.1};
OS Rhinocladiella mackenziei CBS 650.93.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae;
OC Rhinocladiella.
OX NCBI_TaxID=1442369 {ECO:0000313|EMBL:KIX01289.1, ECO:0000313|Proteomes:UP000053617};
RN [1] {ECO:0000313|EMBL:KIX01289.1, ECO:0000313|Proteomes:UP000053617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 650.93 {ECO:0000313|EMBL:KIX01289.1,
RC ECO:0000313|Proteomes:UP000053617};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Rhinocladiella mackenzie CBS 650.93.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; KN847481; KIX01289.1; -; Genomic_DNA.
DR RefSeq; XP_013268425.1; XM_013412971.1.
DR AlphaFoldDB; A0A0D2I659; -.
DR STRING; 1442369.A0A0D2I659; -.
DR GeneID; 25297085; -.
DR VEuPathDB; FungiDB:Z518_09014; -.
DR HOGENOM; CLU_005943_1_0_1; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000053617; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000053617};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..299
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 549..995
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1055 AA; 117493 MW; FAE81C8D3B8AFEEF CRC64;
MALPHARDYV LAAESNQQEA AEIAKAAARR LEGRQTTLIE LVQSLGEYIN DGDEKIRARA
VSYLVAVLSN LPPKYLSRQQ IQVLCQFMCD RIEDGGAIEG LSKLQSLERF TKDMAQTVVR
AIFDHFGDLQ TINQAGRYRV LQLLNELLGH HRNAIRDMGD ESLVGITDLV AGEKDPRNLM
LIFSMLRVLM VEWNITNHVD IMFDSAYAYF PITFRPPPND PYGITAQDLK ERLRGCLAST
SVFAPHTFPN MLDRLDSTST TVKKDVLQTL TACAHNYDPV TIAQYSVTLW DAVKFEVLQA
QEPELAEEAL RVLNGIATSL SYVANNSTNS PLLQYLNPIN KECLEHLQEP ASRQAKASGD
ILRAVSSASI QSFDIVIKAI GPALFTIYQS SEGLMQHRAT LEVANHLFEA AVEVYGSWTK
PSQKNPDGRE NLMGEFKDKF VAIYSQALMA TVKEEVSFRL TAANGLLLVS KMNSMLTDNE
IGLLVQYFDD IVLNEESYGR DELKKRAMTA LAEISRFKPA LISDITFPAF MARLPDSEED
AQPADYDSVL EGLAEISVEK DLLGTLMRRL LNKLDILFHS YQPKDFPYTR AILGTVLFVL
NRAVVDQNAF LDAYYDRVVI GLCRKATDVR TGPLTNENIL DLLGRIVNLI VRHSTAENIQ
KAAENIYLLF RGIKFDGETI RPTLLFEPPV ITILSTWLLA AMPKNVHSRV LTRDQIPGII
DDLVCYASKS TNIAIIQSCL LQIALYVNKH IETADLQFID NLLFQRLSAL RDEPMDESET
PDFNIRLSFS LIKALTVRLS PKTNQYLTSL VDLLDQTQYP REVSRKAAMG FATILASDDV
LSKNNLAQIR LLAPQCVFQT LTPLISEKFK ASQSPSEKEN YLIALSGILS SVPSEIVMPE
LPTLLPLLLQ SLDIANQMVK MATLETLAVV ISHNPSALEE SGHIPALVKR LISVAGGYKS
SSVKLPPFTS PTTAMSAVNL PKTRRLATRC LTLMPKYIVT GTSRANPLIG LKREVLHGLT
NVLDDVKRDV RKEAVDARAA WLRGVDDMND DDDES
//
