ID   A0A0D2IAX5_9EURO        Unreviewed;       668 AA.
AC   A0A0D2IAX5;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE            EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN   ORFNames=Z520_10016 {ECO:0000313|EMBL:KIX94306.1};
OS   Fonsecaea multimorphosa CBS 102226.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX   NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIX94306.1, ECO:0000313|Proteomes:UP000053411};
RN   [1] {ECO:0000313|EMBL:KIX94306.1, ECO:0000313|Proteomes:UP000053411}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 102226 {ECO:0000313|EMBL:KIX94306.1,
RC   ECO:0000313|Proteomes:UP000053411};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR   EMBL; KN848088; KIX94306.1; -; Genomic_DNA.
DR   RefSeq; XP_016628429.1; XM_016780510.1.
DR   AlphaFoldDB; A0A0D2IAX5; -.
DR   STRING; 1442371.A0A0D2IAX5; -.
DR   GeneID; 27715762; -.
DR   VEuPathDB; FungiDB:Z520_10016; -.
DR   OrthoDB; 3682876at2759; -.
DR   Proteomes; UP000053411; Unassembled WGS sequence.
DR   GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   CDD; cd18791; SF2_C_RHA; 1.
DR   Gene3D; 1.10.10.2130; DEAH helicase family, winged-helix domain; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR042035; DEAH_win-hel_dom.
DR   InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR   InterPro; IPR048333; HA2_WH.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR   PANTHER; PTHR18934:SF136; ATP-DEPENDENT RNA HELICASE DHX35-RELATED; 1.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF21010; HA2_C; 1.
DR   Pfam; PF04408; HA2_N; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053411}.
FT   DOMAIN          29..193
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          224..399
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
SQ   SEQUENCE   668 AA;  74483 MW;  36D62D5E151F6D9F CRC64;
     MSDFDLSFIP ALYTPPALLP ISRHRASLLY TIETHQVTVL VGQTGSGKTT QLPQYLEQAG
     WCSRGKCIAV TQPRRVAVTT VATRVAEEMR CQVGEQVGYS IRFEDVTSAK TRIKFLTDGM
     LLREALVDPL FTRYSVIVID EAHERSLSSD ILLGLLKKVK KRRPELRIIV SSATLEAERF
     ADFFTDHDAP DSEQQCRIVS IEGRTYPVDI LYLDQPTDDY LEKAVQTAFT IHQQEPPGDI
     LVFLTGREEI ERATQKLSEL ISTLPPQAQA LQPLPLYAGL STEDQMYVFS EAAENTRKVI
     LATNIAEASV TISGIVYVVD CGFVKLRAFN PNTNIETLTP FPTSKASATQ RAGRAGRTRP
     GKCFRLYTQQ SYSSLPATTT PEIQRSNLAP VVLQLKALGI DNIVRFDFLS PPPSQLLIRA
     FDLLYSLGAV DDYAKLTSPL GTRMAELSAI PPMMAKCLLA SSSPQFDCQN EMLTLAAMTS
     LQGNVWFHHS GEKRAMDSSR RKFAAEEGDQ LTLLNVYRAF VAKGKKEARW CHENHLNFKS
     MQRAVSIRNQ LRRYLERLGV KVDDSDSQVA ATSANTQGKD KTSNILRCLV TGYFSQAAKM
     QPDGTFKSVS GNVTMHAHPT SLLFNRKAEY VVFHELLETG EKVYIKDISK VEKAWLVEFG
     GGYYNLKS
//