ID   A0A0D2II07_9EURO        Unreviewed;       668 AA.
AC   A0A0D2II07;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   RecName: Full=Alpha-actinin-like protein 1 {ECO:0008006|Google:ProtNLM};
GN   ORFNames=Z520_07395 {ECO:0000313|EMBL:KIX96676.1};
OS   Fonsecaea multimorphosa CBS 102226.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX   NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIX96676.1, ECO:0000313|Proteomes:UP000053411};
RN   [1] {ECO:0000313|EMBL:KIX96676.1, ECO:0000313|Proteomes:UP000053411}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CBS 102226 {ECO:0000313|EMBL:KIX96676.1,
RC   ECO:0000313|Proteomes:UP000053411};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA   Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL   Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the alpha-actinin family.
CC       {ECO:0000256|ARBA:ARBA00010255}.
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DR   EMBL; KN848076; KIX96676.1; -; Genomic_DNA.
DR   RefSeq; XP_016630799.1; XM_016777893.1.
DR   AlphaFoldDB; A0A0D2II07; -.
DR   STRING; 1442371.A0A0D2II07; -.
DR   GeneID; 27713141; -.
DR   VEuPathDB; FungiDB:Z520_07395; -.
DR   OrthoDB; 2872403at2759; -.
DR   Proteomes; UP000053411; Unassembled WGS sequence.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   CDD; cd21215; CH_SpAIN1-like_rpt1; 1.
DR   CDD; cd21291; CH_SpAIN1-like_rpt2; 1.
DR   CDD; cd00051; EFh; 1.
DR   Gene3D; 1.20.58.60; -; 2.
DR   Gene3D; 1.10.418.10; Calponin-like domain; 2.
DR   Gene3D; 1.10.238.10; EF-hand; 2.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH_dom.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR014837; EF-hand_Ca_insen.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   PANTHER; PTHR11915:SF435; SPECTRIN BETA CHAIN, NON-ERYTHROCYTIC 5; 1.
DR   PANTHER; PTHR11915; SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF13405; EF-hand_6; 1.
DR   Pfam; PF08726; EFhand_Ca_insen; 1.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00054; EFh; 1.
DR   SMART; SM01184; efhand_Ca_insen; 1.
DR   SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR   SUPFAM; SSF47473; EF-hand; 1.
DR   SUPFAM; SSF46966; Spectrin repeat; 2.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053411};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          10..115
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          124..230
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000259|PROSITE:PS50021"
FT   DOMAIN          484..519
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000259|PROSITE:PS50222"
FT   REGION          639..668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   668 AA;  76597 MW;  5C0E115B27077F8D CRC64;
     MVLLEKQWVN VQEKTFTKWL NNKIVSREVA VKNLVTDLSD GIILIHLLEV LSNESLGRYA
     SNPRLRVQKF ENVNKSLEFI KSRGIQMTNI GAEDVVDGNR KIILGLIWTL ILRFTISDIN
     EEGLTAKEGL LLWCQRKTAC YEGVEVRDFS SSWNDGLAFC ALLDIHRPDL IDFDTLDKSD
     HKGNMKLAFD IASKEIGIPD LLDVEDVADV PKPDERSLMT YIAYWFHAFS AMERVENAGR
     RVEKFVSNMQ GAWEMESAYE KRMRALLQQI RHQRQTWRDS RFEGTYSDAK AQANELASYK
     RNQKRRWVAE KSDLAALLGN IKTKLSTYRL RPYQPPAELR LEVLDYEWAA LSTDEHARSK
     LINETIRDIK NALRKSFADK ANDFALTLNT LSLAISGLEG DVEDQLDHAQ RLSANLGPLE
     QYLEGIAILD EKCQEANIDE NDFTTYTYDE LLYELSLVRA SVQKKLTFLE NQMVARNMTN
     LTPIQLEEFE SVFRHFDRDG TNTLTELEFS AALASLGLVY DEQEMHEKFL EVCHTGIDPS
     MSPISRRQRE SRGVGFEQFI RFMVAVTEDQ NSAEQVFQSF REVADGKPYV TEMDLRHSLI
     PDDLIEDLLQ SMPEHTGPDM EADRDVPKYD YITFMQGMIG DGHHDAGQRD DERGSRSNGV
     TTPTTPRR
//