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Database: UniProt
Entry: A0A0D2JDJ5_9BACT
LinkDB: A0A0D2JDJ5_9BACT
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ID   A0A0D2JDJ5_9BACT        Unreviewed;       467 AA.
AC   A0A0D2JDJ5;
DT   29-APR-2015, integrated into UniProtKB/TrEMBL.
DT   29-APR-2015, sequence version 1.
DT   05-JUL-2017, entry version 18.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=J120_03885 {ECO:0000313|EMBL:KIX85056.1};
OS   candidate division TM6 bacterium JCVI TM6SC1.
OC   Bacteria; Candidatus Dependentiae; Vermiphilus.
OX   NCBI_TaxID=1306947 {ECO:0000313|EMBL:KIX85056.1, ECO:0000313|Proteomes:UP000032214};
RN   [1] {ECO:0000313|EMBL:KIX85056.1, ECO:0000313|Proteomes:UP000032214}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TM6SC1 {ECO:0000313|EMBL:KIX85056.1,
RC   ECO:0000313|Proteomes:UP000032214};
RX   PubMed=23754396; DOI=10.1073/pnas.1219809110;
RA   McLean J.S., Lombardo M.J., Badger J.H., Edlund A., Novotny M.,
RA   Yee-Greenbaum J., Vyahhi N., Hall A.P., Yang Y., Dupont C.L.,
RA   Ziegler M.G., Chitsaz H., Allen A.E., Yooseph S., Tesler G.,
RA   Pevzner P.A., Friedman R.M., Nealson K.H., Venter J.C., Lasken R.S.;
RT   "Candidate phylum TM6 genome recovered from a hospital sink biofilm
RT   provides genomic insights into this uncultivated phylum.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:E2390-E2399(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KIX85056.1}.
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DR   EMBL; ARQD01000003; KIX85056.1; -; Genomic_DNA.
DR   EnsemblBacteria; KIX85056; KIX85056; J120_03885.
DR   Proteomes; UP000032214; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000032214};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000032214}.
FT   DOMAIN      160    288       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      371    440       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     168    175       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   467 AA;  52704 MW;  ACC4D92DA77E5C28 CRC64;
     MVISTIWAEF LKIIKDEAGS RVVDTWFNAV TLKNWNPLEL TVDLEVPNVF VKDWLTLNYI
     KLIQTNLERL FNRSPLHITF TTRSDIIHDQ VIPQVVSVAT PASVTVPVAS IKNHAVPCAS
     ERTYSSGLKN NYRFNTFIVG PNNTLAYAAA HAVVDKPGIL YNPLFLYGSS GLGKTHLLHA
     IGHEVCQKNS KAAVLYQSAD RFVNEFINAI RFDKIHRFQE KYKAVDVLLI DDIQFISGKD
     QTQEAFFHIF NILYEAQKQI VFTSDTEPTK LHGFAARLRS RLACGLVADI STPTFETKIA
     IVKKKAELSE IVIEDQVARY IASLDIDNIR ELEGALIRLV ASASISGQPI TLDFAYTMFE
     KDNVRPQTSP DFDYIVKCVS HYYPYTFDQL RSKGRNKDLA TARHIVMFLI KKLTNKSLRE
     IGIYLGDRDH STVMHAIEKI ENTVRVDSLL AVKIANIEQA IIAQKIG
//
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