ID A0A0D2JR01_9CHLO Unreviewed; 1861 AA.
AC A0A0D2JR01;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=MNEG_6430 {ECO:0000313|EMBL:KIZ01533.1};
OS Monoraphidium neglectum.
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Sphaeropleales; Selenastraceae; Monoraphidium.
OX NCBI_TaxID=145388 {ECO:0000313|EMBL:KIZ01533.1, ECO:0000313|Proteomes:UP000054498};
RN [1] {ECO:0000313|EMBL:KIZ01533.1, ECO:0000313|Proteomes:UP000054498}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SAG 48.87 {ECO:0000313|EMBL:KIZ01533.1,
RC ECO:0000313|Proteomes:UP000054498};
RX PubMed=24373495; DOI=10.1186/1471-2164-14-926;
RA Bogen C., Al-Dilaimi A., Albersmeier A., Wichmann J., Grundmann M.,
RA Rupp O., Lauersen K.J., Blifernez-Klassen O., Kalinowski J., Goesmann A.,
RA Mussgnug J.H., Kruse O.;
RT "Reconstruction of the lipid metabolism for the microalga Monoraphidium
RT neglectum from its genome sequence reveals characteristics suitable for
RT biofuel production.";
RL BMC Genomics 14:926-926(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KK101260; KIZ01533.1; -; Genomic_DNA.
DR RefSeq; XP_013900552.1; XM_014045098.1.
DR STRING; 145388.A0A0D2JR01; -.
DR GeneID; 25739306; -.
DR KEGG; mng:MNEG_6430; -.
DR OrthoDB; 8448at2759; -.
DR Proteomes; UP000054498; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054498};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KIZ01533.1}.
FT DOMAIN 547..1362
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 1483..1798
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 1829..1861
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 65..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 155..192
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1089..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1767..1803
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..468
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1861 AA; 191935 MW; E5B926A3BE5B2EA0 CRC64;
MRALGPLPAL PALSGADAAL RAARAGVTLA EEVSMFAARA AGMPPASRRR ALAALERGLD
ADKDALLAPP APRPPGDAGA APDGACEQRV SGRLLPGVCA AAWRLAHLGA RLDDPGLSGL
AARLLAAAGP LPPDVISFSA AAAAGGGGDD VIYMSSTGDD EAGLAQPASA GGSAPKQRSR
STGPGPASTA AVDGAGGGAA AILTASGAAS VTGDPRRDAM LFGVLELLGS FLAGPDPEVI
GTVQSATRAL LATPEGGAAL RPLQDALNRA WEAAGWDDAA AAARAMVPCY LSSLAGGAGS
AGGDAEAENE EEQQGEVGGG GPQEQQGVEL SEPSLWNPAG PAPHGAWLCR LSSALLSACA
RDPLLRLLAP AAAALPAVAA ALLPHALREV VGAGAGRYSD ERPVGLPPWQ ARAELGAAME
AALLEGAAAA AGAAAPPPAG SDVGRSSGSV DQAKGRSMTS SLQASLSRGP SLGAAGGGPA
RGGPSGAAAG TGADDARQGL RVLLRALEFL RGIHRDSKLT AKGRPPADRL HPYYWDTVYA
LNTDYAAVAR AADACGAHFM ALVYVERWCE LRHGGVALPR AGAKDALGSG AGAAATPALP
SMLAELLPGG TQAQLQAPQQ QQQQQRGRRN AQHLATPQPP RTSRPASAGA ASDPGGAVGA
SDEDSRLSEI EALLLDLYER INDPDGVYAI AAILGSASGR LRLQQCEGRW PEVLAAADER
LQHPAAAPAG AGLGGTAVDL LRALTRMGCR HTAQRYLQSS LANTGGSSGA CAADSATREA
QAELAWRLGE WDTAGQGTAG ALAAPAAQAA VAGTRGEGAA VGNGGGAGGF HAGIFRSLQL
LRAGDGEAFG AALAEARHAA VGALATSGDE SAVTVNHALV RLQMLELLRR AWRIKWAKCA
SDAAASPSAG LAGGAGAAAA AASCATPQLL RRLLGPLGGA ASSAEGVAAG SGALRLRPGD
YHQADQLLAL QACVAQILGR PDVLVVTLQA AAGAARKCGH LAAADAALTR VRHLIRNHAA
ADADAGATAG PFAAMAGGAA GAGAGAWWRP MLRPQSAWLL EAVKLMWDRG QAAGALRELH
SLIAAVEAAD GPPQQQQQQQ QQQQQQQGEP PRHQQLARML SLAGKWSAAT QHGGGKTATV
MELMARGADA LRDGGGGEGE LAARVFFRLA AFADERYKQT QQQMSSPEWR TQQMVIAAKR
RQVEVWNSRL NGPGLNEVTR RHCLISINAL QRVIGADEAA TQQLQDLAQR TLHIALQNYG
RALQAGGSHD LAAVYRLCQL WLALSEEPHV NRRVKEVVEA VPSAKFVPLV YQIASRMSAK
SAAGQQGSNQ KAFQQVLCRA LERMALDHPY HTLYSLIALR NGNLGRNGQP VPTGAAAGAQ
VLARQEFDMD KVQAASALLA RLAKNPQRAE LLKQVEAMVA GFVELAAMQL QPKGSTTPPP
DGWAFPAAIK RRLQSLTLVP VPTAPLPLDP SGAYAHVPTL TEFGPRVGHA GGINAPKVLQ
ATDSDGASHR MLVKSGNDDM RQDAVMQQFF GLVNTLLAGT PDAAARRLGM GTYRVVPISP
AAGLVQWVEN TVPMADYLAG RNRQSGAHAR YRSRGGWSWF DCYNKMSKAP AEQLLPSFLE
CLSRFPPVFH NFFLEAFRAP AAWFEARTRY TRSIAVSSMA GFVIGLGDRH LGNMLLDKSS
AAVLQIDLGV AFEQGMFLNT PETVPFRLTR DVVDGMGAFG VEGPMRRCCE ETLRVLRRNK
EALLTVVEVV LHDPLYRWQM NPVKAQRRQQ DLGAGDGATD GGSGDADGAG TGGGNGGDGS
AQALGNADAA RTVLRVKQKL EGVAGGEGEP LGVAAQVDAL LAEAQDPEQL CRMFVGWSAW
M
//
