ID A0A0D2KCE8_9EURO Unreviewed; 522 AA.
AC A0A0D2KCE8;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=UPF0020 domain-containing protein {ECO:0000259|Pfam:PF01170};
GN ORFNames=Z520_09764 {ECO:0000313|EMBL:KIX94378.1};
OS Fonsecaea multimorphosa CBS 102226.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Chaetothyriomycetidae; Chaetothyriales; Herpotrichiellaceae; Fonsecaea.
OX NCBI_TaxID=1442371 {ECO:0000313|EMBL:KIX94378.1, ECO:0000313|Proteomes:UP000053411};
RN [1] {ECO:0000313|EMBL:KIX94378.1, ECO:0000313|Proteomes:UP000053411}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CBS 102226 {ECO:0000313|EMBL:KIX94378.1,
RC ECO:0000313|Proteomes:UP000053411};
RG The Broad Institute Genomics Platform;
RA Cuomo C., de Hoog S., Gorbushina A., Stielow B., Teixiera M.,
RA Abouelleil A., Chapman S.B., Priest M., Young S.K., Wortman J., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Fonsecaea multimorphosa CBS 102226.";
RL Submitted (JAN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalytic subunit of an S-adenosyl-L-methionine-dependent
CC tRNA methyltransferase complex that mediates the methylation of the
CC guanosine nucleotide at position 10 (m2G10) in tRNAs.
CC {ECO:0000256|ARBA:ARBA00002425}.
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DR EMBL; KN848087; KIX94378.1; -; Genomic_DNA.
DR RefSeq; XP_016628501.1; XM_016780258.1.
DR AlphaFoldDB; A0A0D2KCE8; -.
DR STRING; 1442371.A0A0D2KCE8; -.
DR GeneID; 27715510; -.
DR VEuPathDB; FungiDB:Z520_09764; -.
DR OrthoDB; 5488599at2759; -.
DR Proteomes; UP000053411; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0009451; P:RNA modification; IEA:UniProt.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR000241; RlmKL-like_Mtase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR016691; tRNA_mtfrase_TRM11.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF3; TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG; 1.
DR Pfam; PF01170; UPF0020; 1.
DR PIRSF; PIRSF017259; tRNA_mtfrase_TRM11; 2.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
DR PROSITE; PS51627; SAM_MT_TRM11; 1.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000053411};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022555};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 220..270
FT /note="UPF0020"
FT /evidence="ECO:0000259|Pfam:PF01170"
FT REGION 354..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 58886 MW; 5923AD4D11CBCAC9 CRC64;
MEYLIRFVQA HESFRRPEIE ALSTLAGLPY EIVSYSETSP FCVVRFAPAV DTHDGEENGL
RAVDDGSFES LEARIRNFES RSILSKSIYE IWGQGRDYDE LHADVERRSH HLWDRYRHVS
FKFSVDSYCS TRDVDQQRQI INSFRYLDLQ GKIKMKHPEV EFAVLEEWLP LTLSSETQGN
APASEAAIDK IAGTSLRRVF LARKIGDSCR WLKEKHDLKK RPYISTTSMD AELALLTANM
ALASPGKLFL DPFVGTGGFM IAAAELGAVV LGSDIDGRSF RGKGLGLDQG VGANFQKYDL
THLFGDCLTS DLTNTPFRCA TTVLKSTDGR WLDGIVCDPP YGVREGLKVL GTKSRQSRME
TADMNSEGSS HSETSNPLTE VLINGVPAHT LPGYIPPKKP YSFTRMLDDI LDFAARTLVD
RGRIAFWMPS ANENEFGEEE VTTIPTHRHL KLKHECIQRF NKWSRRLLVY ERLPWTFDSE
VQIAGCVSRE GISTTSAGYT ADELNPFRRR YFQSFGVDRN GS
//
