ID A0A0D2R692_GOSRA Unreviewed; 893 AA.
AC A0A0D2R692;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=Peptidase M16 N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=B456_002G147500 {ECO:0000313|EMBL:KJB14880.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB14880.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB14880.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; CM001741; KJB14880.1; -; Genomic_DNA.
DR RefSeq; XP_012466864.1; XM_012611410.1.
DR AlphaFoldDB; A0A0D2R692; -.
DR MEROPS; M16.A02; -.
DR EnsemblPlants; KJB14880; KJB14880; B456_002G147500.
DR GeneID; 105785352; -.
DR Gramene; KJB14880; KJB14880; B456_002G147500.
DR OMA; NEMASDK; -.
DR OrthoDB; 129328at2759; -.
DR Proteomes; UP000032304; Chromosome 2.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 4.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR InterPro; IPR032632; Peptidase_M16_M.
DR PANTHER; PTHR43690:SF18; INSULIN-DEGRADING ENZYME-RELATED; 1.
DR PANTHER; PTHR43690; NARDILYSIN; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 2.
DR Pfam; PF16187; Peptidase_M16_M; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 4.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 31..164
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 193..370
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
FT DOMAIN 378..657
FT /note="Peptidase M16 middle/third"
FT /evidence="ECO:0000259|Pfam:PF16187"
FT DOMAIN 662..849
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 893 AA; 103007 MW; 128CC4A16293F0F8 CRC64;
MTVGREDVEI LKPRIDKREY RRIVLRNSLQ VLLISDPDTD KCAASMNVGV GSFCDPVGLD
GLAHFLEHML FYASEKYPLE DSYSKYITEH GGSRNAFTDY EMTNYFFDVN TDCFEEALDR
FAQFFIKPLM SADATMREIK AVDSENKKNL LSDAWRMNQL QKHLSLESHP FHKFSTGNWD
TLYVRPKAKG VDTRQELLKF YEDKYSANLM HLVVYSKESL DKIQCLVEDK FQEIQNSDRS
HFQFPGQPCT SEHLQILVRA VPVKQGHKLR IVWPITPSIL HYKDGPCKYL GHLIGHKGEG
SLFYVLKRLG WATGLSAGEG VCTSEFSFFK VVIGLTDAGQ DRMQDVIGLL FRYIQLLQES
GVCKWIFDEL SAICETGFHY KDKISPMYYV LNISSNMQRY PEKDWLVGSS LPSDFNPTTI
QKILNELSPE SVRIFWESKK FEGLTDKVEP WYGTAYSIEK VSPSTIQAWM SSAPNENLHL
PAPNVFIPTD LSIKNAQEKI KLPVSLRKSS YSKLWYKPDT VFFTPKAYVK INFDCPHAIN
SPETEVLTDL FTRLLMDYLN EYAYYAQVAG LRYHVRCTDG GFQVTLVGYN HKLRILLETI
VDKIAKFEVK PDRFSVIKEM AIKDYQNWKF QQPYEQAKDY FSLILEDQSW PWMEQLEVLP
CLNAEDLAKF APIMLSRAFL ECYIAGNIVH EEAVSMIHHV EDVFFKGSNA ICQPLFPSQI
LRNRVVKLGK GMNYCYSKEG LNPSDENSAL VHYIQVHRDD FKLNVKLQLV ALIAEQAAFH
QLRSVEQLGY ITLLRLRNDS GIHGLQFIIQ STVKDPGHID IRVEAFLKMF ESKLYEMTKD
DFKSNVNALI NMKLEKHKNL SEESQFYWTE IISGAPKFDR REAEASQSIL IFF
//
