ID A0A0D2RY11_GOSRA Unreviewed; 911 AA.
AC A0A0D2RY11;
DT 29-APR-2015, integrated into UniProtKB/TrEMBL.
DT 29-APR-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=DNA mismatch repair proteins mutS family domain-containing protein {ECO:0000259|PROSITE:PS00486};
GN ORFNames=B456_006G063300 {ECO:0000313|EMBL:KJB34381.1};
OS Gossypium raimondii (New World cotton).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=29730 {ECO:0000313|EMBL:KJB34381.1, ECO:0000313|Proteomes:UP000032304};
RN [1] {ECO:0000313|EMBL:KJB34381.1, ECO:0000313|Proteomes:UP000032304}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23257886; DOI=10.1038/nature11798;
RA Paterson A.H., Wendel J.F., Gundlach H., Guo H., Jenkins J., Jin D.,
RA Llewellyn D., Showmaker K.C., Shu S., Udall J., Yoo M.J., Byers R.,
RA Chen W., Doron-Faigenboim A., Duke M.V., Gong L., Grimwood J., Grover C.,
RA Grupp K., Hu G., Lee T.H., Li J., Lin L., Liu T., Marler B.S., Page J.T.,
RA Roberts A.W., Romanel E., Sanders W.S., Szadkowski E., Tan X., Tang H.,
RA Xu C., Wang J., Wang Z., Zhang D., Zhang L., Ashrafi H., Bedon F.,
RA Bowers J.E., Brubaker C.L., Chee P.W., Das S., Gingle A.R., Haigler C.H.,
RA Harker D., Hoffmann L.V., Hovav R., Jones D.C., Lemke C., Mansoor S.,
RA ur Rahman M., Rainville L.N., Rambani A., Reddy U.K., Rong J.K.,
RA Saranga Y., Scheffler B.E., Scheffler J.A., Stelly D.M., Triplett B.A.,
RA Van Deynze A., Vaslin M.F., Waghmare V.N., Walford S.A., Wright R.J.,
RA Zaki E.A., Zhang T., Dennis E.S., Mayer K.F., Peterson D.G., Rokhsar D.S.,
RA Wang X., Schmutz J.;
RT "Repeated polyploidization of Gossypium genomes and the evolution of
RT spinnable cotton fibres.";
RL Nature 492:423-427(2012).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CM001745; KJB34381.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0D2RY11; -.
DR EnsemblPlants; KJB34381; KJB34381; B456_006G063300.
DR Gramene; KJB34381; KJB34381; B456_006G063300.
DR Proteomes; UP000032304; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000032304}.
FT DOMAIN 740..756
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 911 AA; 102646 MW; 5EF75D22B5F7758D CRC64;
MDENFDEQNK LPELKLDAKQ AQGFLSFFKT LPNDPRAVRF FDRRDYYTAH GENATFIAKT
YYRTTTALRQ LGSGSNGLSS VSVNKNMFET ITRDLLLERT DHTLELYEGS GSNWRLMKSA
SPGNLSSFED VLFANNEMQD TPVVVALLPN FRENGCTVGF SYVDLTKRIL GLVEFLDDSH
FTNVESALVA LGCKECLLPL ESGKSSECRT LSDALTRCGV MVTERKKTEF KARDLVQDLG
RLVKGSIEPV RDLVSGFEFA PAALGALLSY AELLADEGNY GNYSICRYNL GSFMRLDSAA
MRALNVLESK TDANKNFSLF GLMNRTCTAG MGKRLLHMWL KQPLLDISEI NSRLDLVQAF
VEDTELRQDL RQHLRRISDI ERLMRNIQRT RAGLQHIVKL YQSSIRVPHI KSALEKYDGQ
FSSLIKERYL DPFELLTDDD HLNKFIALVE TSVDLDQLEN GEYMISPSYD DALATLKSEQ
ESLERQIHNL HKQTAFDLDL PVDKALKLDK GTQFGHVFRI TKKEEPKVRK KLSTQFIVLE
TRKDGVKFTN TKLKKLGDQY QKVLEEYKNC QKELVNRVVQ TTATFSEVFE HLAGFLSELD
VLLSFADLAS SCPTPYTRPR ITPPDVGDIV LEGSRHPCVE AQDWVNFIPN DCRLVRGKSW
FLIITGPNMG GKSTFIRQVG VNILMAQVGC FVPCEKASIS VRDCIFARVG AGDCQLRGVS
TFMQEMLETA SILKGATENS LVIIDELGRG TSTYDGFGLA WAICEHIVEV IKAPTLFATH
FHELTALAHE NGNYELQKKQ IVGVANYHVS AHIDSSSRKL TMLYKAAELE DFSPTSIIST
DAGQEEGSKR KRGYDADDIS RGAAKAHKFL KEFAELPLET MDLKQALQQV TKLKDDLQKD
VNNSEWLQQF F
//
